India is renowned for the development of health science based on Ayurveda, Unani, Siddha and Homeopathy. Ficus religiosa L. is most popular species in these indigenous system of medicines. In F. religiosa, entire plant parts like flowers, leaf, fruit, root, bark, inner part of stem, seeds are used as bioactive ingredients. Recently, some pharmacological reports presented that medicinally active molecules which are important for future medication are obtained majorly from trees. These reports also established an explanation related to antidiabetic, anticancer, antiulcer, anticonvulsant, cell reinforcement, and wound recuperating properties of various parts of F. religiosa. Different parts of F. religiosa (roots, leaves, bark, fruit and seed) contains different types of active constituents which may help to treat various diseases. Extractions of F. religiosa in solvents (Ethanolic extraction, Water extraction, Methanolic extraction, etc.) are depend on the type of disease. Particulate frameworks like nanoparticles have been utilized as a physical way to deal with adjust and improve the pharmacokinetic and pharmacodynamics properties of different kinds of drug molecules. Nanoparticles are very small materials in the size range from 1 to 100 nm. Distinctive kind of nanomaterials are being created by utilizing copper, zinc, titanium, magnesium, gold, alginate and silver. Nanoparticles of F. religiosa improve the medicinal property on different diseases like malignant growth, arthritis and so on. In this manner, the main intention behind writing this article is to present an advanced study on phytochemistry, pharmacological properites and nanotechnology of F. religiosa.