Standardization of Gel for Enamel Remineralization

Golovanenko, A. L.; Berezina, E. S.; Tret’yakova, E. V.; Алексеева, И. В.

doi:10.1007/s11094-016-1384-3

Cited by 3 publications

(3 citation statements)

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“…Bioactive glass in an aqueous environment immediately begins to react in three distinct ways: leaching and exchange of cations, hydrolysis of the SiO 2 matrix, and precipitation of calcium and phosphates, leading to the formation of an appetite layer on the surface of the silica scaffold [44][45][46]. This rapid interaction with the environment is crucial for dental applications, as demonstrated by Dong et al (2011), who explored the in vitro remineralization of human dental enamel by bioactive glasses, finding significant remineralization potential and suggesting the effectiveness of bioactive glass in dental repair and maintenance [41].…”

Section: Discussionmentioning

confidence: 99%

Investigating Bioactive-Glass-Infused Gels for Enamel Remineralization: An In Vitro Study

Raszewski,

Chojnacka,

Mikulewicz

2024

JFB

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Objective: Dental hypersensitivity remains widespread, underscoring the need for materials that can effectively seal dental tubules. This study evaluated the potential of bioactive-glass-infused hydroxyethyl cellulose gels in this context. Methods: Five gels were synthesized, each containing 20% bioactive glass (specifically, 45S5, S53P4, Biomin F, and Biomin C), with an additional blank gel serving as a control. Subjected to two months of accelerated aging at 37 ± 2 °C, these gels were assessed for key properties: viscosity, water disintegration time, pH level, consistency, adhesion to glass, and element release capability. Results: Across the board, the gels facilitated the release of calcium, phosphate, and silicon ions, raising the pH from 9.00 ± 0.10 to 9.7 ± 0.0—a range conducive to remineralization. Dissolution in water occurred within 30–50 min post-application. Viscosity readings showed variability, with 45S5 reaching 6337 ± 24 mPa/s and Biomin F at 3269 ± 18 mPa/s after two months. Initial adhesion for the blank gel was measured at 0.27 ± 0.04 Pa, increasing to 0.73 ± 0.06 Pa for the others over time. Gels can release elements upon contact with water (Ca− Biomin C 104.8 ± 15.7 mg/L; Na− Biomin F 76.30 ± 11.44 mg/L; P− Biomin C 2.623 ± 0.393 mg/L; Si− 45S5-45.15 ± 6.77mg/L, F− Biomin F− 3.256 ± 0.651mg/L; Cl− Biomin C 135.5 ± 20.3 mg/L after 45 min). Conclusions: These findings highlight the gels’ capacity to kickstart the remineralization process by delivering critical ions needed for enamel layer reconstruction. Further exploration in more dynamic, real-world conditions is recommended to fully ascertain their practical utility.

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Section: Discussionmentioning

confidence: 99%

Investigating Bioactive-Glass-Infused Gels for Enamel Remineralization: An In Vitro Study

Raszewski,

Chojnacka,

Mikulewicz

2024

JFB

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“…Various techniques have been developed to synthesize nano-HA, such as the sol-gel procedure 15,16) , Fig. 1 Schematic of methods to fabricate and characterize of nano-HA and gel HA-abalone, and the enamel remineralization procedure.…”

Section: Introductionmentioning

confidence: 99%

“…The absorption process of a substance in the body is influenced by the preparation and the concentration of the materials. A high ion concentration increases the remineralization potential many times compared with saliva 15) . In this study, carbomer-based gel preparations were used because they can easily flow and enter the tooth enamel surface.…”

Section: Introductionmentioning

confidence: 99%

Development of a hydroxyapatite nanoparticle-based gel for enamel remineralization —A physicochemical properties and cell viability assay analysis

et al. 2022

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Nano-hydroxyapatite (nHA) was synthesized from abalone mussel shells (Haliotis asinina) using a precipitation method, and gel HA-Abalone was developed using the carbomer materials with concentrations of 0, 10, 20, 30, and 40 wt%. The specimens used were 25 freshly extracted caries-free premolar teeth, and the treatment was done twice a day for 14 days. Gel HA-Abalone 20 wt%, with a crystallite size of 14.70±1.21 nm, was the best concentration to achieve the best remineralization (~863 VHN) of the superficial layer. Based on the results of cell viability assay on gel HA-Abalone 20 wt%, the growth of NIH/3T3 cells was inhibited beginning at a gel concentration of 1,000 µg/mL, and the half maximal inhibitory concentration (IC50) value was 1,497 µg/mL. Based on to the one-way analysis of variance (ANOVA), the result reflected statistically significant differences in the average of the cell viability and enamel surface microhardness values (p<0.05).

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Study of Remineralizing Activity of Dosage Forms for Treatment of Initial Enamel Caries

Golovanenko¹,

Третьякова²,

Патлусова³

et al. 2018

Farm. farmakol. (Pâtigorsk)

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Одним из перспективных направлений профилактики кариеса зубов является реминерализующая терапия, направленная на нормализацию минерального состава зубной эмали. В результате комплекса, проведенных научно -экспериментальных и клинических исследований, разработаны гель и пленки лекарственные для лечения кариеса эмали. Цель работы -исследование реминерализующей активности лекарственных форм для лечения начального кариеса эмали. Материалы и методы. В качестве активных фармацевтических субстанций в лекарственных формах использовали -кальция хлорид (ФС 42-0006-5675-04 Р.003964.01), калия фосфат двузамещенный (ФС 42-1297-79), натрия фторид (ФС.2.2.0013.15), вспомогательные вещества -гелеобразователь натрий-карбоксиметилцеллюлозу (натрий-КМЦ) С75 (ТУ 6-55-39-90), пластификатор глицерин (ФС.2.2.0006.15), воду очищенную (ФС.2.2.0020.15). Исследование реминерализующей активности проводили методом определения кальция и фосфора в золе эмали in vitro. Количественное определение кальция проводили методом обратного комплексонометрического титрования, фосфора -методом фотоэлектроколориметрии. Также проведено электрометрическое исследование in vivo путем определения электропроводности эмали с помощью аппарата «Дентэст» (Геософт). Результаты и обсуждение. Метод определения кальция и фосфора в золе эмали in vitro основан на озолении зуба и последующим определением в нем кальция и фосфора химическими и инструментальными методами. На основании полученных результатов установлено, что гель и пленки лекарственные для лечения кариеса эмали, достоверно повышают содержание кальция и фосфора в эмали зуба. Проведенное электрометрическое исследование подтвердило повышение твердости структуры эмали после применения пленок лекарственных, вследствие ее реминерализации. Заключение. В результате проведённых исследований in vivo и in vitro установлено, что разработанные лекарственные формы оказывают реминерализующий эффект и могут быть рекомендованы для повышения эффективности профилактики и лечения начального кариеса эмали.

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Standardization of Gel for Enamel Remineralization

Cited by 3 publications

References 1 publication

Investigating Bioactive-Glass-Infused Gels for Enamel Remineralization: An In Vitro Study

Investigating Bioactive-Glass-Infused Gels for Enamel Remineralization: An In Vitro Study

Development of a hydroxyapatite nanoparticle-based gel for enamel remineralization —A physicochemical properties and cell viability assay analysis

Study of Remineralizing Activity of Dosage Forms for Treatment of Initial Enamel Caries

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