“…As previously stated, the natural products derived from the roots, leaves, fruits, or whole plants have a large variance in the concentration of their active substances, depending on such environmental conditions as the sunshine, weather, soil components, and bacteria involved during plant growth, so their standardized production is far from simple. Complicated, modern investigations are necessary to create feasible products [82]. However, it is the large variations not only in the natural herbs which are challenging in the application of phytochemical products, but also in human individuals, who show large personal variability in their gut microbiota, which has an essential role in most of the actions of the remedies.…”