The frequent occurrence of drought events in humid and semi-humid regions is closely related to the global climate variability (GCV). In this study, the Standard Precipitation Evapotranspiration Index (SPEI) was taken as an index to investigate the drought in the Yangtze River Basin (YRB), a typical humid and semi-humid region in China. Furthermore, nine GCV indices, such as North Atlantic Oscillation (NAO) were taken to characterize the GCV. Correlation analysis and a joint probability distribution model were used to explore the relationship between the drought events and the GCV. The results demonstrated that there were six significant spatiotemporal modes revealed by SPEI3 (i.e., seasonal drought), which were consistent with the distribution of the main sub basins in the YRB, indicating a heterogeneity of drought regime. However, the SPEI12 (i.e., annual drought) can only reveal five modes. Precipitation Indices and El Niño/Southern Oscillation (ENSO) Indices were more closely related to the drought events. A causal relationship existed between ENSO precipitation index (ESPI), NAO, East Central Tropical Pacific Sea Surface Temperature (Nino3.4) and Northern Oscillation Index (NOI) and drought in the YRB, respectively. Drought events were most sensitive to the low NAO and high NOI events. This study shows a great significance for the understanding of spatiotemporal characteristics of meteorological drought and will provide a reference for the further formulation of water resources policy and the prevention of drought disasters.tropical Pacific phenomenon worldwide. A number of studies have confirmed that there were connections between ENSO and regional climate extremes like floods and droughts [14]. A concern exists that the ongoing global warming may increase the severity of droughts and many studies have shown that drought severity increases with temperature rise [10,[15][16][17][18]. For instance, from 1972 to 2004, the warming increased global dry areas by 20% to 38% [15]. The Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report [19] proposed a continuous increase in global mean surface air temperature during the 21st century owing to the increase of anthropogenic greenhouse gas concentration [20], indicating an increase in drought frequency, severity and spatial extension in future.Drought can be characterized by many indices such as the Palmer Drought Severity Index (PDSI), Standardized Precipitation Index (SPI) and Standardized Precipitation Evapotranspiration Index (SPEI) [21][22][23]. PDSI and SPI have a wide range of applications, but each of them has its limitations. PDSI takes account of changes in surface water balance so that it is suitable for the measurement of long-term drought conditions, but the acquisition is difficult because the calculation process is complex, and the time scale is limited [24]. SPI takes precipitation as a factor. Although its calculation method is simple and time scale is flexible, it does not consider temperature, evapotranspiration and other influe...