Staphyloccocal scalded skin syndrome in healthy adults

Patel, Girish Khandubhai; Varma, Sujatha; Finlay, A.Y.

doi:10.1046/j.1365-2133.2000.03571.x

Cited by 21 publications

(7 citation statements)

References 12 publications

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“…aureus from blood cultures (Table ) . In addition, as opposed to paediatric patients who are usually in otherwise good health when they develop SSSS, virtually all adults with SSSS were immunocompromised, with chronic renal disease, HIV infection, graft‐versus‐host disease, malignant neoplasms, chemotherapy, intravenous drug abuse or diabetes mellitus . Similar to paediatric patients, adults with SSSS demonstrate a fever, and oedematous erythema of the eyelids and nostrils.…”

Section: Clinical Features In Adultsmentioning

confidence: 99%

Staphylococcal scalded skin syndrome: diagnosis and management in children and adults

Handler

Schwartz

2014

Acad Dermatol Venereol

129

135

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Staphylococcal scalded skin syndrome is a potentially life-threatening disorder caused most often by a phage group II Staphylococcus aureus infection. Staphylococcal scalded skin syndrome is more common in newborns than in adults. Staphylococcal scalded skin syndrome tends to appear abruptly with diffuse erythema and fever. The diagnosis can be confirmed by a skin biopsy specimen, which can be expedited by frozen section processing, as staphylococcal scalded skin syndrome should be distinguished from life threatening toxic epidermal necrolysis. Histologically, the superficial epidermis is detached, the separation level being at the granular layer. The diffuse skin loss is due to a circulating bacterial exotoxin. The aetiological exfoliating toxin is a serine protease that splits only desmoglein 1. The exfoliative toxins are spread haematogenously from a localized source of infection, causing widespread epidermal damage at distant sites. Sepsis and pneumonia are the most feared complications. The purpose of this review is to summarize advances in understanding of this serious disorder and provide therapeutic options for both paediatric and adult patients. Recent epidemiological studies have demonstrated that paediatric patients have an increased incidence of Staphylococcal scalded skin syndrome during the summer and autumn. Mortality is less than 10% in children, but is between 40% and 63% in adults, despite antibacterial therapy. Previously, intravenous immunoglobulin had been recommended to combat Staphylococcal scalded skin syndrome, but a recent study associates its use with prolonged hospitalization.

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Section: Clinical Features In Adultsmentioning

confidence: 99%

Staphylococcal scalded skin syndrome: diagnosis and management in children and adults

Handler

Schwartz

2014

Acad Dermatol Venereol

129

135

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“…SSSS is rare in adults and has a significant mortality rate 1 . It is usually associated with immunosuppression or impaired renal function, but these underlying problems were not evident in our patient.…”

mentioning

confidence: 56%

Staphylococcal scalded skin syndrome as a complication of septic arthritis

et al. 2007

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“…There has been one prior report of SSSS occurring in a patient shortly after receiving chemotherapy for a peripheral neuroectodermal tumor [ 5 ]. However, cases of SSSS occurring in healthy adults have also been reported [ 6 ]. Several cases of SSSS caused by methicillin-resistant S. aureus in adults have been reported [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Staphylococcal Scalded Skin Syndrome in an Adult on Chemotherapy

Lee¹,

Tsibris²,

Mostaghimi³

et al. 2014

Dermatopathology

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Staphylococcal scalded skin syndrome is a toxin-mediated, epidermolytic condition that uncommonly affects adults. A 51-year-old man receiving chemotherapy for leukemia presented with a large geographic erosion with superficial sloughing and multiple smaller lesions elsewhere. Biopsy revealed complete subcorneal splitting with multiple detached fragments of normal-appearing stratum corneum with fragments of attached acantholytic granular keratinocytes. Mild epidermal dysmaturation was also noted. Based on these findings, the patient was started on oral cephalexin, topical mupirocin, and topical clobetasol. His lesions improved significantly over the course of 1 week. © 2014 S. Karger AG, Basel

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Staphyloccocal scalded skin syndrome in healthy adults

Cited by 21 publications

References 12 publications

Staphylococcal scalded skin syndrome: diagnosis and management in children and adults

Staphylococcal scalded skin syndrome: diagnosis and management in children and adults

Staphylococcal scalded skin syndrome as a complication of septic arthritis

Staphylococcal Scalded Skin Syndrome in an Adult on Chemotherapy

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