Staphylococcal endocarditis

Karchmer, Adolf W.

doi:10.1016/0002-9343(85)90374-2

Cited by 61 publications

(2 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also exacerbates the severity of miliaria or prickly heat by clogging the sweat pores via secretion of slimy extracellular polysaccharide substance (Mowad et al, 1995; Bukhari et al, 2016). It also triggers a spectrum of implant related infections (McCann et al, 2008) and several fatal systemic infections such as endocarditis and septicemia (Karchmer, 1985).…”

Section: Introductionmentioning

confidence: 99%

Umbelliferone Impedes Biofilm Formation and Virulence of Methicillin-Resistant Staphylococcus epidermidis via Impairment of Initial Attachment and Intercellular Adhesion

Swetha

Pooranachithra

Ganapathy

et al. 2019

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Staphylococcus epidermidis is an opportunistic human pathogen, which is involved in numerous nosocomial and implant associated infections. Biofilm formation is one of the prime virulence factors of S. epidermidis that supports its colonization on biotic and abiotic surfaces. The global dissemination of three lineages of S. epidermidis superbugs highlights its clinical significance and the imperative need to combat its pathogenicity. Thus, in the current study, the antibiofilm activity of umbelliferone (UMB), a natural product of the coumarin family, was assessed against methicillin-resistant S. epidermidis (MRSE). UMB exhibited significant antibiofilm activity (83%) at 500 μg/ml concentration without growth alteration. Microscopic analysis corroborated the antibiofilm potential of UMB and unveiled its potential to impair intercellular adhesion, which was reflected in auto-aggregation and solid phase adherence assays. Furthermore, real time PCR analysis revealed the reduced expression of adhesion encoding genes (icaD, atlE, aap, bhp, ebh, sdrG, and sdrF). Down regulation of agrA and reduced production of secreted hydrolases upon UMB treatment were speculated to hinder invasive lifestyle of MRSE. Additionally, UMB hindered slime synthesis and biofilm matrix components, which were believed to augment antibiotic susceptibility. In vivo assays using Caenorhabditis elegans divulged the non-toxic nature of UMB and validated the antibiofilm, antivirulence, and antiadherence properties of UMB observed in in vitro assays. Thus, UMB impairs MRSE biofilm by turning down the initial attachment and intercellular adhesion. Altogether, the obtained results suggest the potent antibiofilm activity of UMB and the feasibility of using it in clinical settings for combating S. epidermidis infections.

show abstract

Section: Introductionmentioning

confidence: 99%

Umbelliferone Impedes Biofilm Formation and Virulence of Methicillin-Resistant Staphylococcus epidermidis via Impairment of Initial Attachment and Intercellular Adhesion

Swetha

Pooranachithra

Ganapathy

et al. 2019

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Staphylococcus aureus is a Gram-positive, non-motile, catalasepositive, facultatively anaerobic coccus usually arranged in irregular clusters. S. aureus is a potent human and animal pathogen responsible for infections ranging from boils (Noble and White, 1983) and food poisoning (landolo and Dyer, 1981) to toxic shock syndrome (Gemraell, 1982;Todd et al, 1978) and endocarditis (Karchmer, 1985). Although one of the earliest recognized and best studied human pathogens, S. aureus remains a common agent of severe infection in immunocompetent patients (Cohen, 1986;Kaplan and Tenenbaum, 1982).…”

Section: Literature Reviewmentioning

confidence: 99%

The construction and properties of an integrable plasmid for genomic analysis in Staphylococcus aureus

Luchansky

View full text Add to dashboard Cite

Epidemiology of Coagulase‐Negative Staphylococci and Infections Caused by These Organisms

Rogers

Fey

Rupp

2009

Staphylococci in Human Disease

View full text Add to dashboard Cite

Staphylococcal endocarditis

Cited by 61 publications

References 58 publications

Umbelliferone Impedes Biofilm Formation and Virulence of Methicillin-Resistant Staphylococcus epidermidis via Impairment of Initial Attachment and Intercellular Adhesion

Umbelliferone Impedes Biofilm Formation and Virulence of Methicillin-Resistant Staphylococcus epidermidis via Impairment of Initial Attachment and Intercellular Adhesion

The construction and properties of an integrable plasmid for genomic analysis in Staphylococcus aureus

Epidemiology of Coagulase‐Negative Staphylococci and Infections Caused by These Organisms

Contact Info

Product

Resources

About