Staphylococcal scalded skin syndrome in the Czech Republic: an epidemiological study

Lipový, Břetislav; Brychta, Pavel; Chaloupková, Zuzana; Suchánek, Ivan

doi:10.1016/j.burns.2011.08.005

Cited by 20 publications

(23 citation statements)

References 24 publications

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“…The adjusted in‐hospital mortality of SSSS was low (0·33%) in the present study, which is consistent with results found in two other studies . However, some studies discovered a mortality rate of 3·6–11% in children with SSSS .…”

Section: Discussionsupporting

confidence: 92%

“…The significant difference in age groups compared with patients who were < 2 years old is consistent with a study whose mean age of patient with SSSS was 17·4 days . However, our results indicate that SSSS is more commonly associated with female than male sex, while other studies have reported that male patients were more commonly affected . Interestingly, black race, 2nd quartile household income, public insurance and more chronic conditions were all inversely associated with SSSS.…”

Section: Discussionsupporting

confidence: 90%

“…16 However, our results indicate that SSSS is more commonly associated with female than male sex, while other studies have reported that male patients were more commonly affected. 15,16 Interestingly, black race, 2nd quartile household income, public insurance and more chronic conditions were all inversely associated with SSSS. A previous study also found that white children may be more prone to SSSS than black children.…”

Section: Discussionmentioning

confidence: 94%

“…13 Furthermore, previous studies found conflicting or limited evidence of differences of SSSS prevalence by sex and/ or race/ethnicity. [14][15][16] However, few studies have examined whether there are sociodemographic factors associated with SSSS. In the present study, we sought to describe the incidence, associations, comorbidities, mortality and financial burden of SSSS in U.S. children.…”

Section: What Does This Study Add?mentioning

confidence: 99%

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Epidemiology of staphylococcal scalded skin syndrome in U.S. children

Staiman¹,

Hsu²,

Silverberg

2018

Br J Dermatol

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Summary Background Staphylococcal scalded skin syndrome (SSSS) is a blistering dermatosis caused by exfoliative toxins released from Staphylococcus aureus. Objectives To describe the incidence, costs, length of stay (LOS), comorbidities and mortality of SSSS in U.S. children. Methods The Nationwide Inpatient Sample 2008–2012 was analysed, including a 20% sample of U.S. hospitalizations and 589 cases of SSSS. Results The mean annual incidence of SSSS was 7·67 (range 1·83–11·88) per million U.S. children, with 45·1 cases per million U.S. infants age < 2 years. In multivariable logistic regression models, SSSS was significantly associated with the following (shown as adjusted odds ratio and 95% confidence interval): female sex (1·12, 1·00–1·25), age (2–5 years: 13·31, 11·82–14·99; 6–10 years: 2·93, 2·35–3·66; 11–17 years: 0·44, 0·31–0·63); race/ethnicity (black: 0·69, 0·58–0·84) and season (winter: 2·04, 1·66–2·50; summer: 3·47, 2·86–4·22; autumn: 3·04, 2·49–3·70), with increasing odds over time (2010–2011: 2·28, 2·07–2·51; 2012: 2·98, 2·69–3·30). The geometric mean (95% confidence interval) LOS and cost of hospitalization for patients with vs. without SSSS were 3·2 (3·0–3·4) vs. 2·4 (2·4–2·5) days and $4624·0 ($4250–$5030) vs. $1872 ($1782·7–$1965). Crude inpatient mortality rates (with 95% confidence intervals) were similar for children with vs. without SSSS (0·33%, 0·00–0·79% vs. 0·36%, 0·34–0·39%). SSSS was associated with other infections, including in the upper respiratory tract and skin. Conclusions The prevalence of SSSS appears to be increasing over time, and was associated with a number of sociodemographic factors and other infections. Further studies are needed to confirm these findings and reduce rising rates of SSSS.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 94%

Section: What Does This Study Add?mentioning

confidence: 99%

See 2 more Smart Citations

Epidemiology of staphylococcal scalded skin syndrome in U.S. children

Staiman¹,

Hsu²,

Silverberg

2018

Br J Dermatol

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“…This percentage is close to those reported by other authors from Ireland (30%) and England (21%) [2, 3, 21–23]. MRSA strains were found on three nurses (2.7%), of which only one showed the characteristics of the outbreak strain.…”

Section: Discussionsupporting

confidence: 87%

Rapid containment of nosocomial transmission of a rare community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) clone, responsible for the Staphylococcal Scalded Skin Syndrome (SSSS)

et al. 2017

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BackgroundThe aims of this study were to identify the source and the transmission pathway for a Staphylococcal Scalded Skin Syndrome (SSSS) outbreak in a maternity setting in Italy over 2 months, during 2014; to implement appropriate control measures in order to prevent the epidemic spread within the maternity ward; and to identify the Methicillin-Resistant Staphylococcus aureus (MRSA) epidemic clone.MethodsEpidemiological and microbiological investigations, based on phenotyping and genotyping methods, were performed. All neonates involved in the outbreak underwent clinical and microbiological investigations to detect the cause of illness. Parents and healthcare workers were screened for Staphylococcus aureus to identify asymptomatic carriers.ResultsThe SSSS outbreak was due to the cross-transmission of a rare clone of ST5-CA-MRSA-SCCmecV-spa type t311, exfoliative toxin A-producer, isolated from three neonates, one mother (from her nose and from dermatological lesions due to pre-existing hand eczema) and from a nurse (colonized in her nose by this microorganism). The epidemiological and microbiological investigation confirmed these as two potential carriers.ConclusionsA rapid containment of these infections was obtained only after implementation of robust swabbing of mothers and healthcare workers. The use of molecular methodologies for typing was able to identify all carriers and to trace the transmission.

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Methicillinresistenter Staphylococcus aureus in der Mund-, Kiefer- und Gesichtschirurgie

Karbach

Al‐Nawas

2012

MKG-Chirurg

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Staphylococcal scalded skin syndrome in the Czech Republic: an epidemiological study

Cited by 20 publications

References 24 publications

Epidemiology of staphylococcal scalded skin syndrome in U.S. children

Epidemiology of staphylococcal scalded skin syndrome in U.S. children

Rapid containment of nosocomial transmission of a rare community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) clone, responsible for the Staphylococcal Scalded Skin Syndrome (SSSS)

Methicillinresistenter Staphylococcus aureus in der Mund-, Kiefer- und Gesichtschirurgie

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