Staphylococcal scalded skin syndrome related to an exfoliative toxin A- and B-producing strain in preterm infants

Rieger‐Fackeldey, Esther; Plano, Lisa R. W.; Kramer, Andrea B.; Schulze, Andreas

doi:10.1007/s00431-002-1080-z

Cited by 20 publications

(19 citation statements)

References 16 publications

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“…No neonates had symptoms of neonatal toxic shock syndrome-like exanthematous disease or toxic shock syndrome during the study period. The staphylococcal exfoliative toxins ETA and ETB cause staphylococcal scalded skin syndrome in patients of all ages, including neonates (33). None of our MRSA isolates carried genes for these toxins, and no cases of staphylococcal scalded skin syndrome were observed.…”

Section: Discussionmentioning

confidence: 76%

Clinical and Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Neonatal Intensive Care Unit in the Decade following Implementation of an Active Detection and Isolation Program

et al. 2015

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1, 2). The National Nosocomial Infections Surveillance System observed a Ͼ300% increase in the incidence of late-onset MRSA infections in NICUs, from 0.7 to 3.1 infections/10,000 patient days, between 1995 and 2004 (3). Unique host and environmental factors, including immature immune systems, high frequency of contact with health care providers (4), exposure to numerous invasive procedures, NICU overcrowding and understaffing (5, 6), and prolonged hospitalization (7), make NICU patients at especially high risk of becoming colonized and infected with MRSA. Since colonization with MRSA is a risk factor for development of MRSA infection, prevention of MRSA transmission within the NICU is critical (7,8). Many NICUs have implemented active detection and isolation (ADI) programs, which involve surveillance to rapidly identify affected patients, followed by cohorting and isolation with standard contact precautions, in attempts to prevent MRSA transmission and reduce infection rates.Several large NICUs have published reports regarding the clinical epidemiology of neonatal MRSA following implementation of surveillance, transmission prevention, and/or decolonization strategies (7,(9)(10)(11)(12). Some also incorporated molecular analyses in their studies, including antibiotic susceptibility testing (9, 10), strain typing (9, 11, 12), genotyping (9, 12), and/or Panton-Valentine leukocidin gene detection (9,12). No studies have comprehensively examined all of those molecular features of MRSA and additionally assessed the presence or absence of genes encoding proteins for a variety of staphylococcal toxins and potential virulence factors over an extensive time period following implementation of an ADI program in an NICU.In response to the appearance of MRSA in the NICU at YaleNew Haven Children's Hospital (YNHCH)

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Section: Discussionmentioning

confidence: 76%

Clinical and Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Neonatal Intensive Care Unit in the Decade following Implementation of an Active Detection and Isolation Program

et al. 2015

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“…12,15 In recent times, several SSSS outbreaks reported in neonates were predominantly associated with asymptomatic carriage of ET-producing S. aureus strains. 7,8,10,11,14,[16][17][18] The higher rate of S. aureus skin carriage of people with atopic dermatitis [23][24][25] and the high rate of nasal carriage in hospital staff, 26,27 combined with about 6% of toxinogenic S. aureus strains, 28 may favour the occurrence of such outbreaks.…”

Section: Discussionmentioning

confidence: 95%

“…The French National Centre of Staphylococcal Toxins estimated that the number of cases was about 36 per year between 1994 and 1997. 6 Although SSSS in neonates tends to occur in outbreaks, [7][8][9][10][11][12][13][14][15][16][17][18] there have not been any recent reports in France. Since July 2001, a surveillance system focusing on specific nosocomial infections has been set up in France.…”

Section: Introductionmentioning

confidence: 99%

Nosocomial outbreak of staphylococcal scalded skin syndrome in neonates: epidemiological investigation and control

Helali¹,

Carbonne

Naas

et al. 2005

Journal of Hospital Infection

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“…Pharyngeal swab and gastric aspirate are helpful to isolate staphylococci secreting ETA and ETB. 5 High index of suspicion and prompt intravenous antibiotics help in good outcome. Desquamation usually ceases in 24 hours of antibiotic therapy.…”

Section: Sirmentioning

confidence: 99%

Staphylococcal scalded skin syndrome in a neonate

et al. 2009

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Staphylococcal scalded skin syndrome related to an exfoliative toxin A- and B-producing strain in preterm infants

Abstract: the carrier of this strain had contact with both patients, suggesting that this individual was the vector between the two patients but not necessarily the source of the original infection. Strict infection control measures were implemented and no further spread of the disease occurred.

Cited by 20 publications

References 16 publications

Clinical and Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Neonatal Intensive Care Unit in the Decade following Implementation of an Active Detection and Isolation Program

Clinical and Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Neonatal Intensive Care Unit in the Decade following Implementation of an Active Detection and Isolation Program

Nosocomial outbreak of staphylococcal scalded skin syndrome in neonates: epidemiological investigation and control

Staphylococcal scalded skin syndrome in a neonate

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