Staphylococcal Toxin.

Panton, P.N.; Valentine, F.C.O.

doi:10.1016/s0140-6736(01)24468-7

Cited by 273 publications

(188 citation statements)

References 5 publications

Supporting

Mentioning

179

Contrasting

Unclassified

Order By: Relevance

“…This was illustrated by the intense leukocytic response in the lesion of immune animals and the absence of a leukocytic response in the non-immune animal. That culture filtrates of staphylococci may possess a leukocidin has been previously described (15,16) and it is possible that in the non-immune animal the absence of leukocytes in the lesion is attributable to this leukocidin effect. Neutralization of the toxin would therefore allow the leukocytes to survive in the lesion (17).…”

Section: Discussionmentioning

confidence: 92%

Studies on the Pathogenesis of Staphylococcal Infection

Goshi

Cluff

Johnson

1961

The Journal of Experimental Medicine

View full text Add to dashboard Cite

Necrosis of rabbit skin produced by thermal injury was found to result in a striking increase in local infectivity of staphylococci that were coagulase-positive and hemolytic, but no local increase in the infectivity of non-pathogenic staphylococci. Infection produced in necrotic burns extended beyond the area of burn and was characterized by hemorrhage, edema, and necrosis of contiguous normal skin. Such infections, however, never resulted in bacteriemia or metastatic abscesses, and there was no effect of the necrotic burn upon the infectivity of staphylococci injected into normal skin of the burned animal. Recovery of rabbits from severe burn infections was associated with the development of high titers of serum antibody to the alpha hemolysin or dermonecrotoxin of the staphylococcus. Thirty to 100 days after the initial burn infection, it was found that rabbits could no longer be infected in a necrotic burn, although infection induced in normal skin of these resistant animals was no different from that in normal rabbits. Immunity to infection by pathogenic staphylococci in necrotic burns could be induced by vaccination with potent alpha hemolysin toxoid, and this immunity was passively transferable with rabbit antiserum. No strain specificity was detected for this immunity in that immunization with toxoid prepared from bacteriophage type 52/42B/80/81 staphylococci protected animals against infection in a necrotic burn by other typable and non-typable staphylococci. Histopathological study of infected necrotic burns in normal rabbits showed extensive necrosis, hemorrhage, edema, and many masses of bacteria but leucocytic infiltration was observed only at the margin of the infection. In contrast, the infected necrotic burns in animals immunized with alpha hemolysin toxoid showed few bacteria and marked leucocytic infiltration throughout the burn. These experiments have, therefore, demonstrated a significant immunity to infection by pathogenic staphylococci in necrotic tissue but not in normal skin, associated with serum antibody to the alpha hemolysin or dermonecrotoxin of the bacteria. The implications of these findings are discussed.

show abstract

Section: Discussionmentioning

confidence: 92%

Studies on the Pathogenesis of Staphylococcal Infection

Goshi

Cluff

Johnson

1961

The Journal of Experimental Medicine

View full text Add to dashboard Cite

show abstract

“…[6] Although surveillance and improved case recognition may have contributed, this rapid increase is of growing international concern. In the United States, 36% of all S. aureus infections from 2004 to 2008 were PVL positive.…”

Section: Discussionmentioning

confidence: 99%

“More than skin deep”: Recurrent primary hand abscesses in a warehouse operative

Kearney

O’Connor

Fitzpatrick

et al. 2015

Case Reports in Plastic Surgery and Hand Surgery

View full text Add to dashboard Cite

A 25-year-old male right-hand dominant warehouse operator presented with two hand infections within 12 weeks both requiring surgical drainage and antimicrobial therapy. Subsequent testing confirmed Panton-Valentine leukocidin-positive Staphylococcus aureus (PVL-SA). This case highlights the need for prompt multidisciplinary management of hand infections to consider, diagnose and manage atypical infections.

show abstract

“…As the results of the chest X-ray were normal, computed tomography (CT) scan of the abdomen and pelvis was requested. This did not show any intra-abdominal pathology, but lesson of the month (1) Not your typical pneumonia Panton-Valentine leukocidin is a cytotoxin produced by Staphylococcus aureus. It was initially discovered by Van deVelde in 1894 due to its ability to lyse leukocytes.…”

Section: Investigations and Treatmentmentioning

confidence: 90%