Staphylococci Harboured by People in Western Highlands of New Guinea

Rountree, PhyllisM.

doi:10.1016/s0140-6736(56)90747-4

Cited by 35 publications

(10 citation statements)

References 6 publications

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“…This study also revealed that carriage rates were lower in Aboriginal/Torres Strait Islanders, and others have found that people with non-Caucasian ethnicities, e.g. Mexicans, Hispanics and New Guinea Highlanders, have lower rates of S. aureus nasal carriage than do Caucasians [26,28].…”

Section: Discussionsupporting

confidence: 69%

Nasal carriage of Staphylococcus aureus, including community-associated methicillin-resistant strains, in Queensland adults

Munckhof¹,

Nimmo

Schooneveldt

et al. 2009

Clinical Microbiology and Infection

104

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Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are emerging in southeast Queensland, Australia, but the incidence of carriage of CA-MRSA strains is unknown. The aim of this study was to assess the nasal carriage rate of S. aureus, including CA-MRSA strains, in the general adult population of southeast Queensland. 396 patients presenting to general practices in two Brisbane suburbs and 303 volunteers randomly selected from the electoral rolls in the same suburbs completed a medical questionnaire and had nasal swabs performed for S. aureus. All isolates of S. aureus underwent antibiotic susceptibility testing and single-nucleotide polymorphism (SNP) and binary typing, including determination of Panton-Valentine leukocidin (PVL). The nasal carriage rate of methicillin-susceptible S. aureus (MSSA) was 202/699 (28%), a rate similar to that found in other community-based nasal carriage studies. According to multivariate analysis, nasal carriage of S. aureus was associated with male sex, young adult age group and Caucasian ethnicity. Only two study isolates (one MSSA and one CA-MRSA) carried PVL. The nasal carriage rate of MRSA was low, at 5/699 (0.7%), and only two study participants (0.3%) had CA-MRSA strains. CA-MRSA is an emerging cause of infection in southeast Queensland, but as yet the incidence of carriage of CA-MRSA in the general community is low.

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Section: Discussionsupporting

confidence: 69%

Nasal carriage of Staphylococcus aureus, including community-associated methicillin-resistant strains, in Queensland adults

Munckhof¹,

Nimmo

Schooneveldt

et al. 2009

Clinical Microbiology and Infection

104

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“…The human host has shown genetic predisposition to S. azirezts carriage in some cases [20]. For instance, race or HLA type may influence this [21]. Numerous bacterial components have been implicated in the initial adherence process that leads to successful colonisation of the nasal epithelium, e.g., specific bacterial receptors for surface proteins, including those for collagen [4], fibronectin [5] and fibrinogen [22].…”

Section: Discussionmentioning

confidence: 99%

Coagulase and protein A polymorphisms do not contribute to persistence of nasal colonisation by Staphylococcus aureus

Belkum

Eriksen

Sijmons

et al. 1997

Journal of Medical Microbiology

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The nasal carriage rate of Staphylococcus aureus was examined in a longitudinal study of 31 healthy Danish volunteers. Each person was classified as persistent (>8 positive cultures from 10 examinations), an intermittent carrier (50-80% positive cultures) or an ocassional carrier (positive cultures on 10--40% of ocassions only). One hundred and twenty strains from these persons were subjected to phage typing and random amplification of polymorphic DNA (RAPD) analysis. Phage and RAPD typing were in close agreement. RAPD confirmed the spread of a particular S. aureus clone (phage type 95) throughout Denmark. However, no common genotype or phenotype characteristics of S. aureus that could separate persistent from intermittent or incidental colonisers were identified. The immunoglobulin binding protein A and the prothrombin binding coagulase protein are both putative S. aureus virulence or defence factors. Analysis of polymorphisms in the variable repeat regions in the genes for these proteins showed no correlation between the number of repeat units and, consequently, the protein structure with the ability of strains to persist in the human nasal mucosa. The amount of protein A, detectable by its IgG binding activity, appeared not to be correlated to persistence of carriage. Thus protein A and coagulase gene polymorphisms do not seem to play a significant role in the propensity of S. aureus to colonise human nasal epithelium. Furthermore, based on the genetic heterogeneity encountered among the S. aureus strains it is suggested that within the current study population, no single clonal lineage of S. aureus has increased capability to colonise the human nasal epithelium.

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“…The few carried out in the topics have reported that there is a low frequency of nasal S. aureus carriage in non-whites (Findlay and Abrahams, 1946;Rountree, 1956). Millian et al (1960 have also reported that in a study of adults in the USA the frequency of nasal carriage amongst blacks was very low and was significantly lower in blacks than whites.…”

Section: Discussionmentioning

confidence: 99%

Nasal Carriage of Staphylococcus Aureus in a Population of Healthy Nigerian Students

Lamikanra

Paul²,

Akinwole

et al. 1985

Journal of Medical Microbiology

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SUMMARY. The nasal carrier-rate of Staphylococcus aureus in 548 Nigerians aged 9-32 years and attending various educational establishments was 56.4%. This rate decreased with increasing age. A significantly greater proportion of females (65.0%) than males (46.5%) were carriers, but the excess in females was apparent only in subjects aged >20 years. Mucoid strains of S . aureus, which gave a negative slide-coagulase reaction, were found in 21.5% of carriers aged 10-15 years, but were absent from members of other age-groups. A considerable proportion of all the strains tested were resistant to commonly used antibiotics.

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Staphylococci Harboured by People in Western Highlands of New Guinea

Cited by 35 publications

References 6 publications

Nasal carriage of Staphylococcus aureus, including community-associated methicillin-resistant strains, in Queensland adults

Nasal carriage of Staphylococcus aureus, including community-associated methicillin-resistant strains, in Queensland adults

Coagulase and protein A polymorphisms do not contribute to persistence of nasal colonisation by Staphylococcus aureus

Nasal Carriage of Staphylococcus Aureus in a Population of Healthy Nigerian Students

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