Staphylococcus aureus bacteraemia mortality: a systematic review and meta-analysis

Bai, Anthony D.; Lo, Carson K L; Komorowski, Adam S; Suresh, Mallika; Guo, Kevin; Garg, Anubha; Tandon, Pranav; Senécal, Julien; Corpo, Olivier Del; Stefanova, Isabella; Fogarty, Clare; Butler‐Laporte, Guillaume; McDonald, Emily G.; Cheng, Matthew P.; Morris, Andrew M.; Loeb, Mark; Lee, Todd C.

doi:10.1016/j.cmi.2022.03.015

Cited by 119 publications

(58 citation statements)

References 32 publications

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“…They included 536 791 patients from 341 studies published between 1991 and 2021. They found an estimated mortality of 18% at 1 months, 27% at 3 months and 30% at 1 year [4 ▪ ]. As compared to prior to 2001, mortality decreased over time, with an adjusted odds ratio (aOR) of 0.88 (95% CI 0.75–1.03) for 2001 to 2010 and 0.82 (95% CI 0.69–0.97) for 2011 onwards.…”

Section: Recent Epidemiological and Outcome Datamentioning

confidence: 99%

Update on Staphylococcus aureus bacteraemia

Tabah

Laupland

2022

Current Opinion in Critical Care

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Purpose of reviewTo review recently published evidence relevant to Staphylococcus aureus bacteremia (SAB).Recent findingsStaphylococcus aureus is the most common pathogen causing co-infections and superinfections in patients with COVID-19. Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia ratios have sharply risen during the pandemic. SAB mortality is 18% at 1 month and 27% at 3 months but has gradually decreased over the last 30 years. Recurrences and reinfections are common (9%). Standardised items to define complicated SAB, and a new cut-off defining persisting bacteremia after 2 days with positive blood cultures have been proposed. Multiple antibiotic combinations have been trialled including vancomycin or daptomycin with β-lactams, fosfomycin, or clindamycin, without significant results. In the recently published guidelines, vancomycin remains the first line of treatment for MRSA bacteremia. For the management of methicillin-susceptible Staphylococcus aureus, cefazolin less frequently causes acute kidney injury than flucloxacillin, and when susceptibility is demonstrated, de-escalation to penicillin G is suggested.SummaryOur review confirms that Staphylococcus aureus represents a special aetiology among all causes of bloodstream infections. Pending results of platform and larger trials, its distinct epidemiology and determinants mandate careful integration of clinical variables and best available evidence to optimize patient outcomes.

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Section: Recent Epidemiological and Outcome Datamentioning

confidence: 99%

Update on Staphylococcus aureus bacteraemia

Tabah

Laupland

2022

Current Opinion in Critical Care

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“…In particular, MRSA has become one of the most crucial epidemiological problems in hospitals worldwide, resulting in a large number of premature deaths [ 4 ]. A recent meta-analysis, focusing on the all-cause mortality of S. aureus and MRSA, found more than one-third of patients who have S. aureus will die within 3 months, and the index of MRSA was higher [ 5 ]. Therefore, for diagnosing and treating patients timely, it is vital to establish a reliable and rapid method to detect S. aureus and MRSA [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the loop-mediated isothermal amplification assay for Staphylococcus aureus detection: a systematic review and meta-analysis

Long

Lin

Chen

et al. 2022

Ann Clin Microbiol Antimicrob

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Background Staphylococcus aureus can cause many diseases and even death. It’s important to detect Staphylococcus aureus rapidly and reliably. The accuracy of a novel test named LAMP in detecting Staphylococcus aureus is unclear. Therefore, a systematic review and meta-analysis were conducted to evaluate the accuracy of the LAMP assay for Staphylococcus aureus detection. Methods Four databases were searched for relevant studies. Meta-DiSc 1.4.0 and Stata 12.0 were used for statistical analysis. At the same time, we used QUADAS-2 to assess the studies we included. Two groups of subgroup analysis were done to differentiate the diagnostic effects of various LAMP tests and in cases of different gold standards. Results 11 studies were identified and 19 2 × 2 contingency tables were extracted in our study. The results showed that both pooled sensitivity and specificity of the LAMP assay were 99% (95% CI 99–100). Conclusion The LAMP assay demonstrated high sensitivity and specificity in diagnosing Staphylococcus aureus.

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“… S. aureus bacteraemia (SAB) represent a significant burden of disease globally, with a 30 day mortality of approximately 20%, that has not substantially changed in over two decades [3]. This is despite general improvements to disease control (that have led to a decline in MRSA rates), improved laboratory diagnostics, and the availability of relatively newer classes of antimicrobial agents (e.g.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic MALDI-TOF MS can differentiate between high and low toxic Staphylococcus aureus bacteraemia isolates as a predictor of patient outcome

et al. 2022

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Staphylococcus aureus bacteraemia (SAB) is a major cause of blood-stream infection (BSI) in both healthcare and community settings. While the underlying comorbidities of a patient significantly contributes to their susceptibility to and outcome following SAB, recent studies show the importance of the level of cytolytic toxin production by the infecting bacterium. In this study we demonstrate that this cytotoxicity can be determined directly from the diagnostic MALDI-TOF mass spectrum generated in a routine diagnostic laboratory. With further development this information could be used to guide the management and improve the outcomes for SAB patients.

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Staphylococcus aureus bacteraemia mortality: a systematic review and meta-analysis

Cited by 119 publications

References 32 publications

Update on Staphylococcus aureus bacteraemia

Update on Staphylococcus aureus bacteraemia

Evaluation of the loop-mediated isothermal amplification assay for Staphylococcus aureus detection: a systematic review and meta-analysis

Diagnostic MALDI-TOF MS can differentiate between high and low toxic Staphylococcus aureus bacteraemia isolates as a predictor of patient outcome

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