Staphylococcus aureus bacteremia mortality across country income groups: A secondary analysis of a systematic review

Bai, Anthony D.; Lo, Carson K L; Komorowski, Adam S; Suresh, Mallika; Guo, Kevin; Garg, Anubha; Tandon, Pranav; Senécal, Julien; Corpo, Olivier Del; Stefanova, Isabella; Fogarty, Clare; Butler‐Laporte, Guillaume; McDonald, Emily G.; Cheng, Matthew P.; Morris, Andrew M.; Loeb, Mark; Lee, Todd C.

doi:10.1016/j.ijid.2022.06.026

Cited by 16 publications

(12 citation statements)

References 27 publications

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“…These limitations are inherent to using antigen-based read-outs in plasma and render it even more complex to link PAD4 and PAD2 antigen levels towards PAD activity and their functional effect on targeted proteins. Second, ADAMTS13 activity and the binding capacity of ADAMTS13 to ultra-large VWF multimers are known to be reduced in inflammatory conditions beyond infection [49,50], and this is likely independent of the effect of PADs [4]. Furthermore, the observed drop in ADAMTS13 activity in vivo might be not only due to inactivation by citrullination, but also due to either increased degradation of ADAMTS13, or decreased production of ADAMTS13 by hepatic stellate cells following infection.…”

Section: Discussionmentioning

confidence: 99%

“…Staphylococcus aureus ( S. aureus ) is a gold medallist in manipulating the host immune response [1,2] and the human haemostatic system [3], rendering it a deadly pathogen with a mortality of up to 30% [4]. This high mortality, the rising incidence of S. aureus infections and the growing antibiotic resistance emphasize the need to address this infectious disease as a global health priority [5].…”

Section: Introductionmentioning

confidence: 99%

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Peptidylarginine deiminase 4 and ADAMTS13 activity in Staphylococcus aureus bacteraemia

Martens,

Peetermans,

Vanassche

et al. 2023

Phil. Trans. R. Soc. B

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Staphylococcus aureus infection is associated with increased levels of neutrophil extracellular traps (NETs) and von Willebrand factor (VWF), and with reduced activity of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motifs, member 13). Peptidylarginine deiminase 4 (PAD4) contributes to NET formation and inactivates ADAMTS13 in vitro . The role of PADs in the dynamics of NETs, VWF and ADAMTS13 has not yet been studied. We thus aimed to assess the longitudinal evolution of NETs, PADs, VWF and ADAMTS13 activity in S. aureus infection. Plasma samples from S. aureus bacteraemia patients were longitudinally collected and analysed for NETs, PAD4/PAD2, VWF and ADAMTS13 activity. Correlation analyses with clinical data were performed. Recombinant PAD4 and S. aureus were assessed in vitro for their potential to modulate ADAMTS13 activity. Sixty-seven patients were included. Plasma levels of NETs, VWF, PAD4 and PAD2 were increased and ADAMTS13 activity was decreased. Levels of PADs were negatively correlated with ADAMTS13 activity. NETs were positively correlated with PADs, and negatively with ADAMTS13 activity. In vitro , recombinant PAD4 but not S. aureus reduced ADAMTS13 activity in plasma. Levels of PAD4 and PAD2 correlate with reduced ADAMTS13 activity, with neutrophils as the likely source of PAD activity in S. aureus bacteraemia. This article is part of the Theo Murphy meeting issue ‘The virtues and vices of protein citrullination’.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Peptidylarginine deiminase 4 and ADAMTS13 activity in Staphylococcus aureus bacteraemia

Martens,

Peetermans,

Vanassche

et al. 2023

Phil. Trans. R. Soc. B

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“…Although in recent years the incidences of healthcare‐associated MRSA infections have declined in China, Europe and the United States, they still present a significant clinical challenge in low‐ and middle‐income countries (Bai et al, 2022 ). Despite this decline, data from the United States indicate mortality due to MRSA infection remains higher than any other antibiotic resistant pathogen, with over 20,000 deaths reported in 2018 (Kourtis et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Novel antimicrobial strategies to treat multi‐drug resistant Staphylococcus aureus infections

Douglas

Wulandari

Lovell

et al. 2023

Microbial Biotechnology

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Antimicrobial resistance is a major obstacle for the treatment of infectious diseases and currently represents one of the most significant threats to global health. Staphylococcus aureus remains a formidable human pathogen with high mortality rates associated with severe systemic infections. S. aureus has become notorious as a multidrug resistant bacterium, which when combined with its extensive arsenal of virulence factors that exacerbate disease, culminates in an incredibly challenging pathogen to treat clinically. Compounding this major health issue is the lack of antibiotic discovery and development, with only two new classes of antibiotics approved for clinical use in the last 20 years. Combined efforts from the scientific community have reacted to the threat of dwindling treatment options to combat S. aureus disease in several innovative and exciting developments. This review describes current and future antimicrobial strategies aimed at treating staphylococcal colonization and/or disease, examining therapies that show significant promise at the preclinical development stage to approaches that are currently being investigated in clinical trials.

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“…Food can be contaminated at every step of the supply chain hence the importance to develop a rapid and sensitive food pathogen detection method (Karimi 2022) (Painter et al 2013). Salmonella and staphylococcus, among the most important foodborne pathogen, are generally associated with food poisoning and illnesses around the world, with an increasing incidence in low-income or developing countries (Stanaway et al 2019;Hindy et al 2022;Bai et al 2022). It has been estimated that Salmonella infectious doses vary between 10 1 -10 9 CFU, and outbreaks have been registered for doses of 2.5 CFU, 6-23 CFU, and < 10 CFU respectively in chocolate, hamburger, and chocolate bars (Greig and Todd 2010).…”

Section: Introductionmentioning

confidence: 99%

Development of a one-step sample to answer multiplex Hyper-branched Rolling Cycle Amplification (pR@FRET- MB@mHSRCA) with tunable hybrid signaling (pR@FRET-MB) for simultaneous pathogen detection in food

Yang

Yuan

et al. 2023

Preprint

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Salmonella and Staphylococcus foodborne diseases are the majors causes of human diseases and food losses impacting negatively society's well-being and economy. It is primordial to establish a simple and efficient method for specific detection and identification of bacteria. Hence the necessity of the isothermal amplification method. We designed a triple-probe multiplex rolling circle amplification procedure for the simultaneous detection of Salmonella and Staphylococcus. The long padlock probes were designed to target InvA and GlnA of respectively salmonella and staphylococcus and tagged with fluorophores. A pH-based detection method was then established for the visual detection of the targeted pathogens while the Fluorescence signal was used to efficiently identify the pathogen. After optimization of the detection procedure conditions, the one-step mHSRCA could be conducted at room temperature (30°C) for 3 hours. It shows specificity for both staphylococcus and salmonella with a detection limit of 0.039 µM/µl when the fluorescence signal is concern and 0.078µM/µl for the colorimetric signal when the synthetic bacteria gene target is used after 30minutes of test. The simulative test of the present method for effective detection of both bacteria spiked in milk show after 3 hours of amplification a detection limit of 10 CFU/ml and 5CFU/ml for respectively Staphylococcus and Salmonella when the fluorescent signal is concerned. The colorimetric signal the detection limit was 10x101 CFU/ml and 5x101 CFU/ml. In summary, the triple-probe-multiplex rolling circle amplification method could be effectively used for screening food against foodborne pathogens within hours with good specificity, high sensitivity, and easy result reading.

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Staphylococcus aureus bacteremia mortality across country income groups: A secondary analysis of a systematic review

Cited by 16 publications

References 27 publications

Peptidylarginine deiminase 4 and ADAMTS13 activity in Staphylococcus aureus bacteraemia

Peptidylarginine deiminase 4 and ADAMTS13 activity in Staphylococcus aureus bacteraemia

Novel antimicrobial strategies to treat multi‐drug resistant Staphylococcus aureus infections

Development of a one-step sample to answer multiplex Hyper-branched Rolling Cycle Amplification (pR@FRET- MB@mHSRCA) with tunable hybrid signaling (pR@FRET-MB) for simultaneous pathogen detection in food

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