Staphylococcus aureus in Atopic Dermatitis: Past, Present, and Future

Hwang, Jonwei; Jaros, Joanna; Shi, Vivian Y.

doi:10.1097/der.0000000000000589

Cited by 16 publications

(17 citation statements)

References 72 publications

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“…27 Our study adds new evidence to the potential and current trend to target the skin microbiome for AD management as we further understand the role of skin microbiome dysbiosis and S. aureus in its pathogenesis. 11 Though follow-up studies should be conducted to assess the effect of Endobioma on the skin microbiome composition, our results both show the rapid anti-S. aureus activity of the cream in vitro and its efficacy in managing AD in vivo.…”

Section: Discussionmentioning

confidence: 69%

“…9 S. aureus levels are associated with AD disease severity, flare frequency and symptoms that directly impact QoL. [10][11][12] Its toxins stimulate proinflammatory cytokine and chemokine production causing itching, burning sensations, and pain, 13,14 and create a vicious itch-scratch cycle. [15][16][17] During AD flares, treatment aims to reduce inflammation and itching, rebuild the epidermal barrier, and prevent secondary infections.…”

Section: Introductionmentioning

confidence: 99%

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Topical S. aureus - Targeting Endolysin Significantly Improves Symptoms and QoL in Individuals With Atopic Dermatitis

Moreau¹,

Seité²,

Aguilar³

et al. 2021

JDD

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Atopic dermatitis (AD) is a chronic skin condition affecting an increasing number of children and adults whose quality of life is impacted by chronic itch and pain. It is characterized by an altered epidermal barrier, skin inflammation, and skin microbiome dysbiosis particularly over-colonization of Staphylococcus aureus. The efficacy and tolerance of a cream containing a S. aureus-targeting technology (endolysin) was assessed in an open-label, two-week study in children and adults with mild-to-moderate atopic dermatitis. A total of 43 patients ranging from 7 months to 57 years old were included and all patients finished the study without any tolerance problem. Disease severity, measured with SCORAD, quickly reduced by 43% in 7 days and by 68 % in 14 days. The benefit was perceived by the whole panel with a marked improvement in overall QoL. This study shows the efficacy of a highly specific S. aureus-targeted technology in alleviating symptoms and improving QoL in children and adults with atopic dermatitis. It could also be beneficial in reducing and preventing flares in subjects with S. aureus load due to its good tolerance and specific action.

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Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Topical S. aureus - Targeting Endolysin Significantly Improves Symptoms and QoL in Individuals With Atopic Dermatitis

Moreau¹,

Seité²,

Aguilar³

et al. 2021

JDD

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“…epidermidis способен оказывать влияние на стабильность структуры микробиома кожи, течение воспалительных процессов, а также целостность кожного барьера. S. epidermidis участвует в подавлении роста патогенных микроорганизмов двумя путями: напрямую, образуя секретируемые бактериоцины, сериновые протеазы и фенол-растворимые модулины, а также опосредованно, индуцируя образование антимикробных пептидов кератиноцитами кожи [23,24]. Бактериоцины -рибосомально синтезируемые белки с антибактериальными свойствами, являющиеся наиболее распространенным механизмом бактериальной защиты -до 99% микроорганизмов продуцируют хотя бы один бактериоцин [25].…”

Section: роль коагулаз-негативных стафилококков в поддержании гомеост...unclassified

“…Изменения микробиома зависят от состояния кожи: структура микробного сообщества при обострении и в ремиссии АД существенно различается. Обострению заболевания предшествует увеличение колонизации кожи микроорганизмами вида S. aureus, а также снижение разнообразия микробиома [24]. Подобные изменения ассоциированы с более тяжелым течением, напротив, колонизация кожи коагулаз-негативными стафилококками, увеличение разнообразия микробного сообщества кожи наблюдаются у пациентов с мень-шим значением индекса SCORAD [46,47].…”

Section: S LI и соавт выявили что снижение уровня церамидов Cer[ah]c3...unclassified

“…Штаммы S. aureus клонального комплекса 1 чаще встречаются у пациентов с мутацией в гене филаггрина. Микроорганизмы, относящиеся к этой группе, способны экспрессировать гены, ассоциированные с образованием энтеротоксинов В и С, а также являются потенциальным резервуаром MRSA [24].…”

Section: S LI и соавт выявили что снижение уровня церамидов Cer[ah]c3...unclassified

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Disorders of the skin microbiome in atopic dermatitis and psoriasis

Nikolaeva

Monakhov

Sokolovskiy

2021

Vestnik dermatologii i venerologii

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The notion of skin microbiome encompasses a heterogeneous group of microorganisms that belong to various taxonomic units, such as bacteria, archaea, viruses, and fungi. The impact of these microbial community constituents upon the epidermal barrier condition, and upon the immune system functioning, is being intensely scrutinized. There is a particular interest in studying the role that the microorganisms of genus Staphylococcus spp. play in the course of physiological and pathological processes occurring in the skin. This review examines in detail the interaction of the microorganisms of genus Staphylococcus spp. with the microbial community constituents, as well as with the skin immune system in normal condition and in the condition associated with inflammatory dermatoses. There are also the data given on S. aureus pathogenicity factors, the data on the impact of this microorganism upon the course of atopic dermatitis, and upon the course of psoriasis. The review examines the role that coagulase-negative staphylococci, S. epidermidis in particular, play in maintaining the microbiome homeostasis. The review as well examines the impact of the skin microbiome upon the development and activity of the skin immune system, and upon maintaining the integrity of the epidermal barrier.

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