2013
DOI: 10.1371/journal.pone.0080119
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Staphylococcus aureus Keratitis: A Review of Hospital Cases

Abstract: BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) infection is an important public health issue. The study aimed to characterize the patient demographics, clinical features, antibiotic susceptibility, and clinical outcomes of keratitis caused by S. aureus, and to make a comparison between MRSA and methicillin-sensitive S. aureus (MSSA) isolates.Methodology/Principal findingsPatients (n = 59) with culture-proven S. aureus keratitis treated in Chang Gung Memorial Hospital between January 1, 2006, and … Show more

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Cited by 49 publications
(46 citation statements)
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“…1,2,6,28 However, reports suggest the majority of ocular MRSA infections are equivocal to MSSA in terms of complication rates and final visual outcomes. 3,4,11,20,29,30 Furthermore, the clinical virulence of MRSA is likely overrepresented in the literature since only the more serious infections are cultured and reported. 5,6,12,25,26 …”
Section: Discussionmentioning
confidence: 99%
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“…1,2,6,28 However, reports suggest the majority of ocular MRSA infections are equivocal to MSSA in terms of complication rates and final visual outcomes. 3,4,11,20,29,30 Furthermore, the clinical virulence of MRSA is likely overrepresented in the literature since only the more serious infections are cultured and reported. 5,6,12,25,26 …”
Section: Discussionmentioning
confidence: 99%
“…Surprisingly, MRSA had lower susceptibility to gentamicin than anticipated (85.94%), as a survey published at the same institution from 1993 to 2010 showed 100% susceptibility to gentamicin for nine MRSA isolates., 18 In a review of the literature, ocular MRSA susceptibility rates tended to vary; although, susceptibility to sulfamethoxazole/trimethoprim was generally reported to be high (greater than 90%), which was consistent with our findings. 5,9,1117,29 However, some studies reported lower MRSA susceptibility rates to sulfamethoxazole/trimethoprim, ranging from 66.6% to 80%. 9,11,12,16,20,36 We believe these differences reflect regional and populational variations, and recognize that our results may differ from other studies.…”
Section: Discussionmentioning
confidence: 99%
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“…This is in part due to the ease of performing the procedure, but also, while this treatment appears simple, the sterile procedure has to be followed properly. Furthermore, the antibiotic resistance increases [39][40][41][42][43] and the most virulent pathogens can be selected.…”
Section: Infectious Keratitis Following Corneal Crosslinkingmentioning
confidence: 99%
“…[3] S. aureus is one of pathogens causing keratitis, a visionthreatening disease. [6,7] It is an aerobic Gram-positive bacterium carried by 50-60% of normal population and can readily find access to the eyes. A study has shown that S. aureus is the most common bacteria causing contact lensrelated keratitis.…”
Section: Introductionmentioning
confidence: 99%