Staphylococcus aureus throat carriage is associated with ABO-/secretor status

Nurjadi, Dennis; LePendu, Jacques; Kremsner, Peter G.; Zanger, Philipp

doi:10.1016/j.jinf.2012.05.011

Cited by 35 publications

(29 citation statements)

References 40 publications

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“…Among these compounds was tannic acid, a common component in teas and other plant-derived foods. Because S. aureus colonizes the oropharynx and oral cavity (2,27,28) and is likely to encounter this compound during colonization, we focused our efforts on tannic acid. We first confirmed and expanded the result from the screen, showing that tannic acid inhibited S. aureus biofilm formation at low micromolar concentrations in a concentration-dependent manner (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Emerging evidence suggests that, in addition to the nasopharynx, S. aureus commonly colonizes the oropharynx and oral cavity (2,27,28). Since tea is a commonly consumed beverage that inhibits surface colonization in our in vitro models, we tested if tea could impact S. aureus colonization in a rodent model.…”

Section: Resultsmentioning

confidence: 99%

“…Current decolonization strategies involve applying topical agents such as mupirocin to the nose. Several recent studies have identified the oropharynx as another common site of S. aureus colonization (2,27,28). Because hospital efforts to track and eliminate S. aureus colonization focus primarily on the nasal cavity, these approaches are not likely to affect throat carriage, and therefore, this reservoir for future infection may persist.…”

Section: Figmentioning

confidence: 99%

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Tannic Acid Inhibits Staphylococcus aureus Surface Colonization in an IsaA-Dependent Manner

et al. 2013

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Staphylococcus aureus is a human commensal and pathogen that is capable of forming biofilms on a variety of host tissues and implanted medical devices. Biofilm-associated infections resist antimicrobial chemotherapy and attack from the host immune system, making these infections particularly difficult to treat. In order to gain insight into environmental conditions that influence S. aureus biofilm development, we screened a library of small molecules for the ability to inhibit S. aureus biofilm formation. This led to the finding that the polyphenolic compound tannic acid inhibits S. aureus biofilm formation in multiple biofilm models without inhibiting bacterial growth. We present evidence that tannic acid inhibits S. aureus biofilm formation via a mechanism dependent upon the putative transglycosylase IsaA. Tannic acid did not inhibit biofilm formation of an isaA mutant. Overexpression of wild-type IsaA inhibited biofilm formation, whereas overexpression of a catalytically dead IsaA had no effect. Tannin-containing drinks like tea have been found to reduce methicillin-resistant S. aureus nasal colonization. We found that black tea inhibited S. aureus biofilm development and that an isaA mutant resisted this inhibition. Antibiofilm activity was eliminated from tea when milk was added to precipitate the tannic acid. Finally, we developed a rodent model for S. aureus throat colonization and found that tea consumption reduced S. aureus throat colonization via an isaA-dependent mechanism. These findings provide insight into a molecular mechanism by which commonly consumed polyphenolic compounds, such as tannins, influence S. aureus surface colonization.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

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Tannic Acid Inhibits Staphylococcus aureus Surface Colonization in an IsaA-Dependent Manner

et al. 2013

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“…Bacteria in the digestive tract of secretors may benefit from a constant nutritional supply by the secretion of blood group antigens in the mucus that lines the intestinal mucosa. The composition of this commensal flora is a contributing mechanism of the ABO and Lewis blood group-dependent risk for inflammatory bowel disease,36 various gastrointestinal infections38––40 and could influence the development of chronic inflammation in the pancreas.…”

Section: Discussionmentioning

confidence: 99%

Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study

Weiss

Schurmann

Guenther

et al. 2014

Gut

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“…ABO antigens are present on a wide variety of cells, especially those of the gastrointestinal mucosa, and provide receptors for gastrointestinal infections (rotavirus, norovirus; ref. 95), they also have been linked to bacterial throat carriage (96), and B group antigen specifically is known to modulate the composition of the intestinal microbiota (97).…”

Section: Discussionmentioning

confidence: 99%

Childhood Determination of Hodgkin Lymphoma among U.S. Servicemen

Mack

Norman

Rappaport

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Hodgkin lymphoma in young adults is inexplicably linked to economic development.Methods: We conducted a nested case-control study of the 656 servicemen with Hodgkin lymphoma diagnosed between ages 17 to 32 while on active duty in the U.S. military during 1950-68. Controls, chosen randomly from the servicemen on duty at the time, were matched on service, birth year, and induction date. Information came from preinduction records and military records for the period ending at onset or the equivalent date.

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Staphylococcus aureus throat carriage is associated with ABO-/secretor status

Cited by 35 publications

References 40 publications

Tannic Acid Inhibits Staphylococcus aureus Surface Colonization in an IsaA-Dependent Manner

Tannic Acid Inhibits Staphylococcus aureus Surface Colonization in an IsaA-Dependent Manner

Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study

Childhood Determination of Hodgkin Lymphoma among U.S. Servicemen

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