Staphylococcus caprae meningitis following intraspinal device infection

Benedetti, Paolo; Pellizzer, Giampietro; Furlan, Francesca; Nicolin, Roberto; Rassu, Mario; Sefton, Armine

doi:10.1099/jmm.0.2008/000356-0

Cited by 17 publications

(18 citation statements)

References 14 publications

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“…Besides indwelling device-associated bone or joint infection, S. caprae has also been reported as a causative pathogen of bacteremia, endocarditis, urinary tract infection, meningitis, and otitis externa [7][8][9]. As in the present case, previously reported cases of bacteremia due to S. caprae have been associated with intravascular catheters, especially in non-neonatal patients [7].…”

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confidence: 65%

Central line-associated bacteremia caused by drug-resistant Staphylococcus caprae after chemotherapy for acute myelogenous leukemia

et al. 2010

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confidence: 65%

Central line-associated bacteremia caused by drug-resistant Staphylococcus caprae after chemotherapy for acute myelogenous leukemia

et al. 2010

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“…Among 386 S. caprae isolates reported in the literature, 17 of 22 were well identified by API Staph [7,9,13,15,18,20,23,40], [8,10,14,[18][19][20]23,38,41], 64 of 85 were well identified by Vitek [3,16,29,30,39,41], none of 15 were well identified by Microscan [3,29], nine were well identified by Phoenik [30], five of eight were well identified by 16S PCR (plus two false positives) [6,13,27,41], seven were well identified by soda gene sequencing [6,22], four were well-identified by tuf gene sequencing [6,41], 65 of 74 were well identified by ribotyping 16S-23S printer [4,8,23,40], 17 of 19 were well identified by internal transcribed spacer PCR [12,42], 17 of 19 were well identified by multiplex-PCR [32], four of five were well identified by pulsed-field gel electrophoresis [15], one was well identified by rpoB gene sequencing [31], one was well identified by autolysin gene sequencing [43], and 88 of 89 were w...…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, S. caprae strains cause community-acquired and/or hospital-acquired infections in humans (Table 1), e.g. acute otitis externa [3,5], peritonitis [6], urinary tract infections [7,8], pneumonia [9], endocarditis [8], meningitis [10], and many cases of bacteraemia [4,8,9,[11][12][13][14][15][16]. Some S. caprae strains isolated from goats produce toxic shock syndrome toxin 1 [17].…”

Section: Introductionmentioning

confidence: 99%

Staphylococcus caprae bone and joint infections: a re-emerging infection?

Seng

Barbe²,

Pinelli

et al. 2014

Clinical Microbiology and Infection

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Staphylococcus caprae has been recently classified as a human pathogen, but the incidence of S. caprae in human bone and joint infections (BJIs) is under-reported. In this study, we report 25 cases of S. caprae BJI, and we review the 31 cases published in the literature. Molecular techniques and matrix-assisted laser desorption ionization time-of-flight mass spectrometry improved the identification of clinically relevant S. caprae strains. In this study, 96% of S. caprae BJIs were localized to the lower limbs, and 88% of the cases involved orthopaedic device infections. S. caprae joint prosthesis infections (JPIs), internal osteosynthesis device infections (I-ODIs) and BJIs without orthopaedic device infections were recorded in 60%, 28% and 12% of cases, respectively. Ten (40%) S. caprae BJIs were polymicrobial infections. These infections were associated with past histories of malignancy (p 0.024). Of the 14 bacterial species related to S. caprae BJI, 57% were staphylococci. I-ODIs were significantly associated with polymicrobial infections (p 0.0068), unlike JPIs, which were monomicrobial infections (p 0.0344). Treatment with rifampicin and fluoroquinolone was recorded in 40% of cases. Surgical treatment was performed in 76% of cases, e.g. prosthesis removal (36%), osteosynthesis device removal (24%), and surgical debridement (16%). Thirty per cent of cases were not treated. Relapses were observed mainly in the patients treated by surgical debridement only (p 0.033). In summary, S. caprae BJI is an underestimated hospital-acquired emerging infection. S. caprae BJI is correlated with infections in orthopaedic devices, which must be removed to control the infection.

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“…2 This bacterium has been associated with bone and joint infections, bacteremia, recurring sepsis, urinary infections, endocarditis and meningitis. [3][4][5][6] Our patient reported he was a goat shepherd 30 years ago. Slime production and biofilm formation are traits of S. caprae and they may play a role in conferring virulance to this species.…”

Section: Discussionmentioning

confidence: 99%