Staphylococcus lugdunensis endocarditis with destruction of the ventricular septum and multiple native valves

Ishiekwene, Celestine; Ghitan, Monica; Kuhn-Basti, Margaret; Chapnick, Edward K.; Lin, Yu Shia

doi:10.1016/j.idcr.2016.10.011

Cited by 14 publications

(19 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This case further highlights the pathogenic potential of coagulase-negative staphylococci as in 2 reported series that examined clinical isolates of S. lugdunensis , only a minority of isolates were considered contaminants or colonizing organisms. 5 , 9 The importance of S. lugdunensis was described in 1989 when it was implicated as an etiological pathogen in infective endocarditis. Since then, more than 100 cases of IE due to S. lugdunensis has been reported.…”

Section: Discussionmentioning

confidence: 99%

“…4 Surgical or invasive procedures precede S. lugdunensis infection in 80% of patients, 3 and overall, most (73%) of the infections involve sites below rather than above the waist. 5 In addition, bloodstream infections have been documented to follow femoral artery catheterization 4 and scrotal wounds.…”

mentioning

confidence: 99%

“…While other coagulase-negative staphylococci ( S. epidermidis ) can be associated with a high rate of heart failure and valvular complications in the setting of endocarditis, the mortality rate of S. lugdunensis endocarditis rivals that of Staphylococcus aureus . 5 The ability of S. lugdunensis to cause endocarditis and prosthetic device-associated infections alludes to the fact that the organism has the ability to interact with host tissues and proteins to improve its virulence. Staphylococcus lugdunensis pathogenesis is related to production of an enzyme called atlL by S. lugdunensis gene, which appears to be implicated in cell autolysis and separation.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Staphylococcus lugdunensis from gluteal abscess to destructive native triple valve endocarditis

Majid

2018

SMJ

View full text Add to dashboard Cite

We herein present the case of a 43-year-old male diabetic patient who presented with an aggressive form of infective endocarditis involving the tricuspid, mitral and aortic valves following a gluteal abscess due to infection with Staphylococcus lugdunensis. This coagulase-negative organism which is generally considered a component of the normal flora of the skin has however recently emerged as an unusually virulent pathogen responsible for both nosocomial and community-acquired infections. The case demonstrates the importance of paying utmost attention and ensuring a logical conclusion to the identification of persistent coagulase-negative blood cultures. In addition, it also shows the importance of early identification of this organism and aggressive antibiotic administration to avert endocarditis because of the unusual virulence of the organism. Staphylococcus lugdunensis is rarely a clinical specimen contaminant, and its isolation warrants further investigation and concerted treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Staphylococcus lugdunensis from gluteal abscess to destructive native triple valve endocarditis

Majid

2018

SMJ

View full text Add to dashboard Cite

show abstract

“…Even though S. lugdunensis is highly susceptible to a myriad of antibiotic therapies, S. lugdunensis is more aggressive than other CNS as S. lugdunensis carries a high mortality rate in endocarditis patients [16]. Thus, if S. lugdunensis is isolated, transesophageal echocardiography should be conducted to evaluate for IE [48][49][50]. Treatment with a β-lactam and debridement of foreign material should be pursued [48][49][50].…”

Section: Treatmentmentioning

confidence: 99%

Staphylococcus lugdunensis: Review of Epidemiology, Complications, and Treatment

Parthasarathy¹,

Shah²,

Sager³

et al. 2020

Cureus

View full text Add to dashboard Cite

Staphylococcus lugdunensis is a species of coagulase-negative staphylococci (CNS) that induces a variety of infectious diseases, including skin and soft tissue infection (SSTI), infective endocarditis (IE), and bone and PJI. This review article underscores the important points in the literature about S. lugdunensis infections, including its epidemiology, diagnosis, and treatment, as well as specific types of infections it can cause. Anatomical and age-related distributions of S. lugdunensis SSTIs have been noted, though they most commonly occur as abscesses. S. lugdunensis can also manifest as an aggressive form of IE presenting with valve destruction and abscess formation, frequently requiring surgery and with a high mortality rate. Bone and joint infections caused by S. lugdunensis are also more invasive than infections by other species of CNS. The clinical presentation of S. lugdunensis infection in SSTI, IE, and bone/joint infection is frequently more similar to that of S. aureus infection than that of other CNS infections, necessitating species-level differentiation of CNS for proper diagnosis. Though historically, this depended upon biochemical tests that were neither routine nor reliable, the implementation of matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) in clinical laboratories has made identification of CNS species such as S. lugdunensis more practical. Imaging modalities, especially the fluorodeoxyglucose (FDG) with positron emission tomography (PET), are another important emerging trend in the diagnosis of infectious diseases such as S. lugdunensis infection. S. lugdunensis remains highly susceptible to a wide gamut of antibacterial therapies, which is uncharacteristic of other CNS. Infections can usually be treated by antibiotics traditionally used for CNS such as oxacillin. The breakpoints for S. lugdunensis are higher than those of other CNS and similar to S. aureus breakpoints. In the case of aggressive IE or bone/joint infection by S. lugdunensis, it is recommended to treat with a βlactam agent. Further study is needed to understand the diversity, virulence, and population structure of this species, as well as its role in other infections, such as urinary tract infections (UTIs), respiratory infections, peritonitis, and bacteremia.

show abstract

“…[ 8 ] The third case described a case of IE with destruction of the mitral and AoVs, left ventricular outflow tract abscess, and subsequent VSD. [ 9 ] There are no reported cases of new VSD secondary to IE in the pediatric population currently reported.…”

Section: Discussionmentioning

confidence: 99%

Acquired ventricular septal defect due to infective endocarditis

et al. 2018

View full text Add to dashboard Cite

Acquired intracardiac left-to-right shunts are rare occurrences. Chest trauma and myocardial infection are well-known causes of acquired ventricular septal defect (VSD). There have been several case reports describing left ventricle to right atrium shunt after infective endocarditis (IE). We present here a patient found to have an acquired VSD secondary to IE of the aortic and tricuspid valves in the setting of a known bicuspid aortic valve. This is the first case reported of acquired VSD in a pediatric patient in the setting of IE along with literature review of acquired left-to-right shunts.

show abstract

Staphylococcus lugdunensis endocarditis with destruction of the ventricular septum and multiple native valves

Cited by 14 publications

References 14 publications

Staphylococcus lugdunensis from gluteal abscess to destructive native triple valve endocarditis

Staphylococcus lugdunensis from gluteal abscess to destructive native triple valve endocarditis

Staphylococcus lugdunensis: Review of Epidemiology, Complications, and Treatment

Acquired ventricular septal defect due to infective endocarditis

Contact Info

Product

Resources

About