StAR, a bridge from ApoE, LDL, and HDL cholesterol trafficking to mitochondrial metabolism

Jefcoate, Colin R.; Larsen, Michele Campaigne

doi:10.1016/j.coemr.2019.07.011

Cited by 2 publications

(2 citation statements)

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“…It needs to be confirmed whether there are other potential mechanisms in the regulation of AKAP1 on blood vessels. In addition, AKAP1 may control cholesterol transport by regulating the activity of steroid acute regulatory factors through a post-transcriptional mechanism [23,24] and possibly affecting the structure of mitochondrial-associated endoplasmic reticulum membrane [23,25]. However, no evidence in our study and others showed the relationship between AKAP1 and cholesterol.…”

Section: Original Papercontrasting

confidence: 58%

Serum level of A-kinase anchoring protein 1, negatively correlated with insulin resistance and body mass index, decreases slightly in patients with newly diagnosed T2DM

Zhu

Cheng

Fan

2020

Endokrynologia Polska

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Introduction: At present, the number of people suffering from diabetes and obesity is increasing in China, and also all over the world. Researchers found that decreased expression of A-kinase anchoring protein 1 (AKAP1), which was thought to regulate the function and structure of mitochondria, might be related to these two diseases. However, as far as we know, there is no study about the changes of serum AKAP1 protein in these two diseases. Hence we conducted this experiment to study the relationship between serum levels of AKAP1 with T2DM and obesity. Material and methods: There were 261 subjects involved in the experiment, including 130 patients with newly diagnosed T2DM and 131 individuals with normal glucose tolerance (NGT). They were further divided into four groups as follows. Subjects with NGT and normal weight (NW) were assigned to the NGT+NW group, those with NGT but with overweight (OW) or obesity (OB) were assigned to the NGT+OW/OB group, and so on; the rest were divided into the T2DM+NW group and the T2DM+OW/OB group. Serum AKAP1 levels were tested by ELISA method and compared by T-test. Linear regression was applied to discuss independent factors of AKAP1. Multiple logistic regression was used to analyse the relationship between AKAP1 and the prevalence of T2DM. Results: Serum AKAP1 in the NGT+NW group was 1.74 ± 0.42 ng/mL, higher than that in the NGT+OW/OB group, at 1.59 ± 0.41 ng/mL (t = 2.114, p = 0.036), and the T2DM+OW/OB group, at 1.52 ± 0.36 ng/ml (t = 3.219, p = 0.002). A-kinase anchoring protein 1 in 130 subjects with T2DM was lower than that in subjects with NGT, 1.57 ± 0.35 ng/mL vs. 1.67 ± 0.42 ng/mL, t = 2.036, p = 0.043. Liner regression showed that insulin resistance (IR) and body mass index (BMI) were independent factors negatively related to AKAP1: b = -0.019 and -0.032, respectively. Compared to the highest tertile of AKAP1, the prevalence of T2DM was higher in the other two tertiles; OR was 2.207 (1.203, 4.050) and 2.051 (1.121, 3.753), respectively. Conclusions: Serum AKAP1 level decreases slightly in patients with T2DM and obesity. Subjects with lower leve1s of serum AKAP1 are susceptible to T2DM.

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Section: Original Papercontrasting

confidence: 58%

Serum level of A-kinase anchoring protein 1, negatively correlated with insulin resistance and body mass index, decreases slightly in patients with newly diagnosed T2DM

Zhu

Cheng

Fan

2020

Endokrynologia Polska

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“…Researches indicated that fibrates as hypolipidemic agents could activate PPARα pathway and increase Cyp content, and resulting oxysterol generation may mediate the RCT by regulating the expression of proteins involved in lipid metabolism (Cizkova, 2018; Giampietro, Ammazzalorso, Amoroso, & De Filippis, 2019). Cyp could restrain cholesterol accumulation and AS formation by regulating the proliferation and migration of vascular smooth muscle cells (Bennett, Jørgensen, Clarke, Bennett, & Mallat, 2016; Jefcoate & Larsen, 2019). Ppargc1a as a target could also regulate lipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

Juice fromFructus Rosae Roxburghiinormalizes blood lipids in mice with diet‐induced hyperlipidemia*^†

Song

Shen

2020

Food Science & Nutrition

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generally characterized by high total cholesterol (TC) or triglyceride (TG), or low high-density lipoprotein (HDL). These lipoproteins play important role in regulating the blood lipid. Hypertriglyceridemia is a prevalent risk factor for CVD. Elevated TG levels are also important markers for several types of atherogenic lipoproteins (Malloy & Kane, 2001). LDL can transport the cholesterol on the surface of cells by LDL receptor and scavenger receptor, which can prevent excessive lipid accumulation (Goldstein & Brown, 2009; Hansson & Libby, 2006). Damaged LDL receptor would prompt the development of AS by accumulating intracellular lipid. LDL can be transformed into oxidized low-density lipoprotein (OX-LDL) under free

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StAR, a bridge from ApoE, LDL, and HDL cholesterol trafficking to mitochondrial metabolism

Cited by 2 publications

References 77 publications

Serum level of A-kinase anchoring protein 1, negatively correlated with insulin resistance and body mass index, decreases slightly in patients with newly diagnosed T2DM

Serum level of A-kinase anchoring protein 1, negatively correlated with insulin resistance and body mass index, decreases slightly in patients with newly diagnosed T2DM

Juice fromFructus Rosae Roxburghiinormalizes blood lipids in mice with diet‐induced hyperlipidemia*^†

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StAR, a bridge from ApoE, LDL, and HDL cholesterol trafficking to mitochondrial metabolism

Cited by 2 publications

References 77 publications

Serum level of A-kinase anchoring protein 1, negatively correlated with insulin resistance and body mass index, decreases slightly in patients with newly diagnosed T2DM

Serum level of A-kinase anchoring protein 1, negatively correlated with insulin resistance and body mass index, decreases slightly in patients with newly diagnosed T2DM

Juice fromFructus Rosae Roxburghiinormalizes blood lipids in mice with diet‐induced hyperlipidemia*†

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Juice fromFructus Rosae Roxburghiinormalizes blood lipids in mice with diet‐induced hyperlipidemia*^†