2003
DOI: 10.1074/jbc.r300003200
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StAR-related Lipid Transfer (START) Proteins: Mediators of Intracellular Lipid Metabolism

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Cited by 286 publications
(275 citation statements)
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“…Although increased t-SNARE endocytosis in AnxA6-overexpressing cells cannot be completely ruled out as contributing to the phenotype observed, the ability of AnxA6 to impact on SNARE localization and functioning is probably linked to its association with late endosomes, which plays a crucial role in cholesterol trafficking and homeostasis. Late endosomes are a sorting station and are capable of exporting cholesterol via vesicular (Maxfield and Tabas, 2005; Urano et al , 2008) and nonvesicular (protein-mediated) transport mechanisms involving NPC1 (Garver and Heidenreich, 2002) and cytoplasmic sterol-binding proteins (e.g., oxysterol-binding protein/OSBP-related proteins [OSBP/ORPs], ORP5; Ngo et al , 2010; Du et al , 2011) or through StAR-related lipid transfer domain (START)-domain proteins (Soccio and Breslow, 2003; Alpy and Tomasetto, 2005; Ikonen, 2008). In CHO-A6 cells, cholesterol accumulates in late endosomes, probably due to AnxA6 interference with NPC1 activity.…”
Section: Discussionmentioning
confidence: 99%
“…Although increased t-SNARE endocytosis in AnxA6-overexpressing cells cannot be completely ruled out as contributing to the phenotype observed, the ability of AnxA6 to impact on SNARE localization and functioning is probably linked to its association with late endosomes, which plays a crucial role in cholesterol trafficking and homeostasis. Late endosomes are a sorting station and are capable of exporting cholesterol via vesicular (Maxfield and Tabas, 2005; Urano et al , 2008) and nonvesicular (protein-mediated) transport mechanisms involving NPC1 (Garver and Heidenreich, 2002) and cytoplasmic sterol-binding proteins (e.g., oxysterol-binding protein/OSBP-related proteins [OSBP/ORPs], ORP5; Ngo et al , 2010; Du et al , 2011) or through StAR-related lipid transfer domain (START)-domain proteins (Soccio and Breslow, 2003; Alpy and Tomasetto, 2005; Ikonen, 2008). In CHO-A6 cells, cholesterol accumulates in late endosomes, probably due to AnxA6 interference with NPC1 activity.…”
Section: Discussionmentioning
confidence: 99%
“…It is now wellestablished that StAR functions as a sterol transfer protein [70], binds cholesterol [71,72], mediates the acute steroidogenic response by moving cholesterol from the outer to the inner mitochondrial membrane [73], acts on the outer mitochondrial membrane [73][74][75], and requires the structural change previously described as a pH-dependent molten globule [76]. StAR is also a prototype of a family of proteins that contain START (StAR-related lipid transfer) domains (StarD proteins) [77], of which StarD3/MLN64, StarD4, StarD5 and StarD6 exhibit steroidogenic potential [78,79].…”
Section: Hormonal Regulation Of Steroidogenesismentioning
confidence: 99%
“…RhoGAP activity appears to be solely responsible for this cell response (Sekimata et al, 1999). SAM and START domains could play a role at physiological expression level DLC-1 but are not required for cytoskeleton organization (Soccio and Breslow, 2003).…”
Section: Introductionmentioning
confidence: 99%
“…RhoGAPs (GTPaseactivating proteins) are one of the major classes of regulators of Rho GTPases that convert the active, GTP-bound form of Rho to the inactive, GDP-bound form. RhoGAPs are critical in cell actin cytoskeleton organization, regulation of transcription and cell cycle, control of and membrane trafficking, apoptosis as well as contribute to oncogenic transformation, cancer progression, and tumor metastasis (Boettner and Van Aelst, 2002;Jaffe and Hall, 2002;Peck et al, 2002;Toksoz and Merdek, 2002;Moon and Zheng, 2003;Soccio and Breslow, 2003).…”
Section: Introductionmentioning
confidence: 99%