Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviour

Nep, Elijah I.; Asare-Addo, Kofi; Ghori, Muhammad Usman; Conway, Barbara R.; Smith, Alan M.

doi:10.1016/j.ijpharm.2015.10.071

Cited by 24 publications

(22 citation statements)

References 62 publications

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“…The high costs of the pharmaceuticals produced means it is beyond the reach of the majority of the local population. Plant polysaccharides are coming under increased research interest and this is a resource in abundance in the developing world (Nep et al, 2015). It is therefore important that these polysaccharides are fully characterised to determine their suitability as excipients in drug delivery.…”

Section: Introductionmentioning

confidence: 99%

“…The polysaccharides have been reported to consist of five neutral sugars namely, glucose (6.4 %), rhamnose (12.3 %), arabinose (0.5 %), xylose (0.3 %) and galactose (0.2 %) as well as galacturonic acid (16.3 %) and glucuronic acid (12.1 %) (Nep et al, 2016;Nep and Conway, 2011a;Okafor et al, 2001). Recently, Nep et al(2015Nep et al( , 2016 successfully conducted the enzymatic removal of starch from Grewia gum (GG) resulting in a starch-free Grewia gum (GDS) which differed from the native polysaccharide in the relative proportion of monosaccharides and physicochemical properties (Nep et al, 2016). The same authors then evaluated the native gum and starch-free gum as potential hydrophilic matrix formers for sustained release applications (Nep et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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The influence of hydroalcoholic media on the performance of Grewia polysaccharide in sustained release tablets

Nep

Mahdi

Adebisi

et al. 2017

International Journal of Pharmaceutics

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Co-administration of drugs with alcohol can affect the plasma concentration of drugs in patients. It is also known that the excipients used in the formulation of drugs may not always be resistant to alcohol. This study evaluates effect of varying alcohol concentrations on theophylline release from two grades of Grewia mollis polysaccharides. X-ray microtomography showed that native polysaccharide formulation compacts were not homogenous after the mixing process resulting in its failure in swelling studies. Removal of starch from the native polysaccharide resulted in homogenous formulation compacts resistant to damage in high alcoholic media in pH 6.8 (40%v/v absolute ethanol). Destarched polymer compacts had a significantly higher hardness (375N) than that of the native polysaccharide (82N) and HPMC K4M (146N). Dissolution studies showed similarity at all levels of alcohol tested (f=57-91) in simulated gastric media (pH 1.2). The dissolution profiles in the simulated intestinal fluids were also similar (f=60-94), with the exception of the native polysaccharide in pH 6.8 (40%v/v absolute ethanol) (f=43). This work highlights the properties of Grewia polysaccharide as a matrix former that can resist high alcoholic effects therefore; it may be suitable as an alternative to some of the commercially available matrix formers with wider applications for drug delivery as a cheaper alternative in the developing world.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The influence of hydroalcoholic media on the performance of Grewia polysaccharide in sustained release tablets

Nep

Mahdi

Adebisi

et al. 2017

International Journal of Pharmaceutics

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“…Examples of the mostly used cellulose ethers are: methylcellulose (MC), hydroxypropyl methylcellulose (HPMC), hydroxyethylcellulose (HEC), hydroxypropylcellulose (HPC) and ethyl cellulose (EC). Commonly, these polymers are used as a carrier to develop modified release matrix tablets (Alderman 1984;Asare-Addo et al, 2013;Ghori et al, 2014b;Hogan 1989;Melia, 1990;Nep et al, 2015;Timmins et al, 2014;Wen & Park 2011). However, various authors have reported their use as a binder in tablet compression because they have acceptable compaction properties (Parikh, 2016).…”

Section: Chemistry Of Cellulose Ethersmentioning

confidence: 99%

Powder Compaction: Compression Properties of Cellulose Ethers

Ghori

Conway

2016

British Journal of Pharmacy

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Effective development of matrix tablets requires a comprehensive understanding of different raw material attributes and their impact on process parameters. Cellulose ethers (CE) are the most commonly used pharmaceutical excipients in the fabrication of hydrophilic matrices. The innate good compression and binding properties of CE enable matrices to be prepared using economical direct compression (DC) techniques. However, DC is sensitive to raw material attributes, thus, impacting the compaction process. This article critically reviews prior knowledge on the mechanism of powder compaction and the compression properties of cellulose ethers, giving timely insight into new developments in this field.

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“…Grewia gum is extracted from the inner stem bark of Grewia mollis , a tropical shrub widely distributed in tropical and sub‐tropical Africa that belongs to the Malvaceae family (Kpodo et al , , Nep et al , ). Grewia gum has been employed as hydrophilic matrix to control drug release because of its ability to hydrate and swell upon interaction with fluids (Nep et al , ). Grewia gum has also been explored as a binder and suspending agent in the formulation of pharmaceutical oral drugs (Nep & Conway, , Nep et al , ).…”

Section: Introductionmentioning

confidence: 99%

“…Grewia gum has been employed as hydrophilic matrix to control drug release because of its ability to hydrate and swell upon interaction with fluids (Nep et al , ). Grewia gum has also been explored as a binder and suspending agent in the formulation of pharmaceutical oral drugs (Nep & Conway, , Nep et al , ). Although its use in food formulations has not been extensively evaluated, the pulverised inner bark from the stems of the shrub is already used as thickeners in ethnic food preparation.…”

Section: Introductionmentioning

confidence: 99%

Emulsifying properties of Ghanaian grewia gum

Kpodo

Agbenorhevi

Alba

et al. 2019

Int J of Food Sci Tech

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Grewia gums were extracted with phosphate (PB) and sodium metabisulphite buffers (SMB) and their emulsification properties in acidic oil-in-water emulsions on ageing were studied by means of droplet size distribution, f-potential measurements, interfacial composition analysis and viscometry. PB extracts showed smaller droplet sizes (~10 lm) than SMB isolates (>35 lm) and greater long-term stability. PBstabilised emulsions also demonstrated the least polysaccharide (~0.6 mg m À2 ) and protein (~0.2 mg m À2 ) interfacial coverage compared with SMB counterparts (~1.5 mg m À2 for polysaccharide and~1 mg m À2 for protein). f-Potential measurements revealed negative interfacial charge for all emulsions confirming the presence of polysaccharide-laden interfaces. Droplet size distribution also varied among emulsions during ageing indicating a complex relationship between interfacial composition and stability. The present work shows that different emulsifying properties may be obtained depending on the extraction technique employed that could be exploited in preparation of emulsions for flavour or bioactive-delivery applications.Grewia gum-stabilised emulsions F.M. Kpodo et al.

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Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviour

Cited by 24 publications

References 62 publications

The influence of hydroalcoholic media on the performance of Grewia polysaccharide in sustained release tablets

The influence of hydroalcoholic media on the performance of Grewia polysaccharide in sustained release tablets

Powder Compaction: Compression Properties of Cellulose Ethers

Emulsifying properties of Ghanaian grewia gum

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