Starch Hydrolase Inhibitors from Edible Plants

Liu, Tingting; Huang, Dejian

doi:10.1016/b978-0-12-416555-7.00003-5

Cited by 26 publications

(15 citation statements)

References 80 publications

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“…MW-PAC exhibited greater α-glucosidase inhibition (IC 50 of 259.0 ± 30.8 mg/L) than Con-PAC (IC 50 of 399.1 ± 48.9 mg/L), suggesting that depolymerization of PACs to monomeric catechins enhanced their biological activity. This observation also agrees with the reports that polyphenols are effective inhibitors of α-glucosidase [31]. Interestingly, the activities of both MW-PAC and Con-PAC were comparable to the drug acarbose's IC 50 value (347.4 ± 43.5 mg/L).…”

Section: Discussionsupporting

confidence: 91%

Optimization of Catechin and Proanthocyanidin Recovery from Grape Seeds Using Microwave-Assisted Extraction

et al. 2020

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Grape seed extract (GSE) is a rich source of condensed flavonoid tannins, also called proanthocyanidins (PACs). The high molecular weight of polymeric PAC limits their biological activity due to poor bioavailability. The present study was undertaken to explore the potential applicability of microwave-assisted extraction (MAE) to convert GSE-PAC into monomeric catechins. A central composite design (CCD) was used to optimize the processing conditions for the MAE. The maximum total yield of monomeric catechins (catechin, epicatechin, and epicatechin gallate) and PAC were 8.2 mg/g dry weight (DW) and 56.4 mg catechin equivalence (CE)/g DW, respectively. The optimized MAE condition was 94% ethanol, 170 °C temperature, and a duration of 55 min. Compared to the results for PACs extracted via conventional extraction (Con) (94% ethanol; shaking at 25 °C for 55 min), MAE yielded 3.9-fold more monomeric catechins and 5.5-fold more PACs. The MAE showed higher antioxidant capacity and α-glucosidase inhibitory activity than that of the conventional extract, suggesting the potential use of the MAE products of grape seeds as a functional food ingredient and nutraceutical.

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Section: Discussionsupporting

confidence: 91%

Optimization of Catechin and Proanthocyanidin Recovery from Grape Seeds Using Microwave-Assisted Extraction

et al. 2020

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“…Recently, several stuides have described the ability of plant extracts to inhibit the digestive enzyme α ‐amylase . All samples were able to inhibit the enzyme although BorOF exhibited the highest potency with an IC 50 value of 31.61 µg mL −1 , which was better than those reported for the largely prescribed drug acarbose, which was used as a positive control.…”

Section: Resultsmentioning

confidence: 86%

In vitroinvestigation of the potential health benefits of wild Mediterranean dietary plants as anti-obesity agents withα-amylase and pancreatic lipase inhibitory activities

Marrelli

Loizzo

Nicoletti

et al. 2014

J. Sci. Food Agric.

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“…The polyphenols are known to interact with the enzyme through non-specific binding, leading to inhibition of enzyme activity. The polyphenols tend to more effective on α-glucosidase inhibition with increase with molecular weight and degree of polymerization (30).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Antioxidant, Antidiabetic and Antiobesity Potential of Selected Traditional Medicinal Plants

2019

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This study evaluated potential antidiabetic and antiobesity properties in vitro of selected medicinal plants. The hot water (WE) and ethanol extracts (EE) of sweet gale ( Myrica gale L.), roseroot ( Rhodiola rosea L.), sheep sorrel ( Rumex acetosa L.), stinging nettles ( Utrica dioica L.) and dandelion ( Taraxacum officinale L.) were tested for total antioxidant capacity using ferric reducing antioxidant power (FRAP) and DPPH • scavenging capacity assays, followed by α-amylase, α-glucosidase and formation of advanced glycation end products (AGE) inhibition assays in vitro . Myrica gale EE had the highest total phenolic content (12.4 mmol GAE/L), FRAP value (17.4 mmol TE/L) and DPPH • scavenging activity (IC 50 = 3.28 mg/L). Similarly, Myrica gale also exhibited significantly lower IC 50 values for the percentage inhibition of α-amylase (IC 50 = 62.65 mg/L) and α-glucosidase (IC 50 = 27.20 mg/L) compared to acarbose (IC 50 = 91.71 mg/L; IC 50 = 89.50 mg/L, respectively) ( p ≤ 0.05). The 3T3-L1 preadipocyte study also revealed that Myrica gale EE (54.8%) and stinging nettles (62.2% EE; 63.2% WE) significantly inhibited the adipogenesis in adipocytes in vitro ( p ≤ 0.05). Polyphenols present in these medicinal plants have the potential to use in managing type 2 diabetes and obesity.

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Starch Hydrolase Inhibitors from Edible Plants

Cited by 26 publications

References 80 publications

Optimization of Catechin and Proanthocyanidin Recovery from Grape Seeds Using Microwave-Assisted Extraction

Optimization of Catechin and Proanthocyanidin Recovery from Grape Seeds Using Microwave-Assisted Extraction

In vitroinvestigation of the potential health benefits of wild Mediterranean dietary plants as anti-obesity agents withα-amylase and pancreatic lipase inhibitory activities

Evaluation of Antioxidant, Antidiabetic and Antiobesity Potential of Selected Traditional Medicinal Plants

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