Evaluation of Antioxidant, Antidiabetic and Antiobesity Potential of Selected Traditional Medicinal Plants

Sekhon-Loodu, Satvir; Rupasinghe, H.P. Vasantha

doi:10.3389/fnut.2019.00053

Cited by 119 publications

(80 citation statements)

References 37 publications

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“…The α-amylase inhibitory assay was adapted from Sekhon-Loodu and Rupasinghe, [9] with modification. Briefly, the test extracts, enzyme, and soluble starch were dissolved in 20 mM sodium phosphate buffer containing 6 mM NaCl (pH 6.9).…”

Section: α-Amylase Inhibitory Assaymentioning

confidence: 99%

“…The α-glucosidase inhibitory assay was adapted from Sekhon-Loodu and Rupasinghe, [9] with modification. Briefly, various concentrations of freeze dried ethanolic extracts were prepared in 10 mM potassium phosphate buffer (pH 6.8).…”

Section: α-Glucosidase Inhibitory Assaymentioning

confidence: 99%

“…The prevalence of diabetes has necessitated an increased search for the development of natural remedies and dietary interventions, which are safer alternatives to synthetic drugs for the management of the disease. Growing evidence suggests that phytochemicals such as polyphenols from cereal grains and other medicinal plants offer potential therapeutic benefits such as alleviating diabetes and obesity complications, as well as inhibitory effects against α-amylase and α-glucosidase [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Phenolic Profile, Antioxidant, and Antidiabetic Potential Exerted by Millet Grain Varieties

et al. 2020

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This study evaluated the potential antioxidant and antidiabetic properties in vitro of four millet grain varieties cultivated in South Korea. The free fractions were tested for their total antioxidant capacity using 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS+) and 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays, followed by α-glucosidase, α-amylase, and advanced glycation endproducts (AGEs) formation inhibition assays. The total phenolics, flavonoids, and condensed tannins in the free fractions ranged from 107.8 to 136.4 mg ferulic acid equivalent (FAE)/100 g, 101.3 to 115.8 mg catechin equivalent (CE)/100 g, and 17.65 to 59.54 mg catechin equivalent (CE)/100 g, respectively. Finger Italian millet had the highest total phenolic content (136.4 mg FAE/100 g) and flavonoid content (115.8 mg CE/100 g). Barnyard and finger Italian millet showed the highest DPPH (IC50 = 359.6 µg/mL and 436.25 µg/mL, respectively) and ABTS radical scavenging activity (IC50 = 362.40 µg/mL and 381.65 µg/mL, respectively). Similarly, finger Italian millet also exhibited significantly lower IC50 values for the percentage inhibition of α-glucosidase (18.07 µg/mL) and α-amylase (10.56 µg/mL) as compared with acarbose (IC50 = 59.34 µg/mL and 27.73 µg/mL, respectively) and AGEs formation (33.68 µg/mL) as compared with aminoguanidine (AG) (52.30 µg/mL). All eight phenolic compounds identified in finger Italian millet were flavonoids, with flavanols being the predominant subclass. Taken together, millet flavonoids play important roles in the prevention and management of type 2 diabetes, and hence finger Italian millet has the potential to be developed as a functional food.

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Section: α-Amylase Inhibitory Assaymentioning

confidence: 99%

Section: α-Glucosidase Inhibitory Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Phenolic Profile, Antioxidant, and Antidiabetic Potential Exerted by Millet Grain Varieties

et al. 2020

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“…Dandelion (Taraxacum officinale) merupakan tanaman yang mengandung senyawa polifenol yang berperan sebagai antioksidan yang dapat melindungi sel β dari spesies oksigen reaktif (ROS) sehingga diharapkan mampu mencegah diabetes yang disebabkan oleh ROS (48). Komponen polifenol yang terdapat pada tanaman dandelion menyebabkan aktivasi CAMP yang meningkatkan eksositosis dalam sel β, penghambatan proses degradasi insulin, pencegahan stres oksidatif, regenerasi sel β, perbaikan hipertrofi seluler, dan proliferasi sel-sel di pulau Langerhans (47).…”

Section: Pemanfaatan Dandelion (Taraxacum Officinale) Pada Sebagai Anunclassified

“…Selain itu, polifenol juga diketahui dapat menimbulkan efek antihiperglikemia. Mekanisme yang terjadi adalah dengan mengikat transporter glukosa dan secara kompetitif akan menghambat enzim pencernaan, yaitu enzim alfa-amilase dan alfaglukosidase lebih signifikan daripada acarbosa yang umum digunakan sebagai obat antidiabetes (48). Secara mendalam, diketahui bahwa pada bagian akar dari tanaman dandelion mengandung inulin atau fructooligosaccharides (FOS).…”

Section: Pemanfaatan Dandelion (Taraxacum Officinale) Pada Sebagai Anunclassified

Pemanfaatan Dandelion (Taraxacum Officinale) Pada Diabetes Mellitus Tipe 2

Putri

Fatimah

2019

kesehatan

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Diabetes mellitus was one of WHO priority diseases because the number of sufferers is quite high and always increased in every country, especially in Indonesia. Efforts to manage diabetes mellitus from non-pharmacological, pharmacological, to traditional treatments have been carried out. Indonesia is also a country that has a variety of nutritious plants, but only a few plants have been used as traditional medicine. The purpose of this study was to find out how the utilization would be done using dandelion or Taraxacum officinale for type 2 diabetes mellitus so that the results would be useful to increase knowledge for health providers and the people of Indonesia in utilizing the natural resources in Indonesia. This type of research was a literature review and the method used in this study literature was collecting 21 literature from books and 30 case report and research article journals. Conclusion: One of the medicinal plants found in Indonesia was dandelion plant (Taraxacum officinale) which was known to have antihyperglycemic or antidiabetic effects, but its use in Indonesia was quite rare. Antidiabetic mechanisms of this plant are reabsorption of the glucose in the kidneys, reducing the activity of the enzyme alpha-amylase and alpha-glucosidase, reducing glucose levels in the blood, and inhibiting the flow of potassium channels.

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Effect of a winter savory leaf extract obtained using high hydrostatic pressure on the quality of carrot juice

2020

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BACKGROUND The consumption of vegetable juices has increased due to their characteristics such as freshness/naturalness, high nutritional value, low in calories, and for being a convenient way of consuming bioactive compounds. High hydrostatic pressure (HPP), which has been mainly used to replace thermal processing, is now also being successfully applied as extraction technology to recover bioactive compounds from herbs. The present work aimed to evaluate the effect of supplementation of carrot juice with winter savory leaf aqueous extract on the final juice characteristics. RESULTS The extract was added to raw carrot juice (1.0 mg mL–1), which was then submitted to HPP and stored for 15 days under refrigeration. Microbial analyses were performed during storage time, as also were analyzed the physicochemical properties such as pH, colour, bioactive compound concentration and antioxidant activity. Supplemented juices presented lower microbial counts than the non‐supplemented ones, and, generally, did not present significant changes (P > 0.05) in pH or colour. Concerning the total phenolics and total flavonoids, as well as antioxidant activity, the values were generally higher (P < 0.05) in supplemented juices, which was proven by the high correlation found between total phenolics and ABTS●+ and FRAP assays. CONCLUSIONS These data suggest that the addition of winter savory leaf extract in carrot juice treated with HPP can effectively improve microbial safety throughout refrigerated storage as well as antioxidant activity, without risking other characteristics of the juice, such as the colour or the acidity. © 2020 Society of Chemical Industry

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Evaluation of Antioxidant, Antidiabetic and Antiobesity Potential of Selected Traditional Medicinal Plants

Cited by 119 publications

References 37 publications

Phenolic Profile, Antioxidant, and Antidiabetic Potential Exerted by Millet Grain Varieties

Phenolic Profile, Antioxidant, and Antidiabetic Potential Exerted by Millet Grain Varieties

Pemanfaatan Dandelion (Taraxacum Officinale) Pada Diabetes Mellitus Tipe 2

Effect of a winter savory leaf extract obtained using high hydrostatic pressure on the quality of carrot juice

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