Starch malabsorption and breath gas excretion in healthy humans consuming low- and high-starch diets

Flourié, Bernard; Leblond, A; Florent, C.; Rautureau, M; Bisalli, A.; Rambaud, J C

doi:10.1016/0016-5085(88)90491-x

Cited by 77 publications

(26 citation statements)

References 30 publications

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“…The amount of RS in the diet is more difficult to determine because analytical estimates of RS in specific foods published in food tables record only retrograded amylose (Holland et al, 1988 (1994), 69, 937-942 that 4-10% of starch in mixed diets reaches the large gut (Stephen et al, 1983;Flourie et al, 1988). In order to obtain an estimate of RS and NSPs reaching the large gut, we have therefore taken a conservative estimate of 5% total starch as RS and combined this with NSPs.…”

Section: Methodsmentioning

confidence: 99%

Starch intake and colorectal cancer risk: an international comparison

Cassidy

Bingham²,

Cummings³

1994

Br J Cancer

277

147

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Summary Intakes of starch, non-starch polysaccharides (NSPs), protein and fat have been compared with colorectal cancer incidence in 12 populations worldwide. There were strong inverse associations between starch consumption and large bowel cancer incidence (large bowel r = -0.70, colon r = -0.76). There was no significant relation with NSPs, although the association with large bowel cancer incidence was still significant when NSP was combined with resistant starch (RS) to give an estimate of fermentable carbohydrate (large bowel r = -0.52, colon r = -0.60). The relationships between starch, RS and NSPs and cancer incidence remained statistically significant after adjusting for fat and protein intakes. The strong inverse associations found here suggest a potentially important role for starch in protection against colorectal cancer and correspond with the hypothesis that fermentation in the colon is the mechanism for preventing colorectal cancer. Measures of both starch and NSPs need to be included in future epidemiological studies of diet and bowel cancer.

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Section: Methodsmentioning

confidence: 99%

Starch intake and colorectal cancer risk: an international comparison

Cassidy

Bingham²,

Cummings³

1994

Br J Cancer

277

147

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“…With the intubation technique no bacterial fermentation could have occurred since samples were immediately frozen in liquid N,. The differences between the ileostomy and intubation techniques emphasize the role of the method used for estimating starch digestion in vivo in humans (Stephen et al 1983;Englyst & Cummings, 1986;FlouriC et al 1988;Faisant et al 1993~). Although simple sugars are generally considered to be well absorbed in the small intestine, the results with banana flour confirm that a substantial fraction can escape digestion because of limited time and/or capacity for hydrolysis and absorption in the ileum (Faisant et al 1993~).…”

Section: Discussionmentioning

confidence: 99%

Digestion of raw banana starch in the small intestine of healthy humans: structural features of resistant starch

et al. 1995

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The digestion of freeze-dried green banana flour in the upper gut was studied by an intubation technique in six healthy subjects over a 14 h period. Of or-glucans ingested, 837% reached the terminal ileum but were almost totally fermented in the colon. Structural study of the resistant fraction showed that a small part of the a-glucans which escaped digestion in the small intestine was composed of oligosaccharides from starch hydrolysis, whereas the rest was insoluble starch in granule form with physical characteristics similar to those of raw banana starch. Passage through the small intestine altered granule structure by increasing susceptibility to further or-amylase hydrolysis. Compared with resistant starch values in vivo, those obtained with the in vitro methods tested were inadequate to estimate the whole fraction of starch reaching the terminal ileum.

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“…There is currently no evidence that the slight reduction in intestinal residence time impairs the intestinal absorption of carbohydrates. As done previously (23), in this study we used a modified method that took into account theoretical considerations stressed by Davis et al (24) and Levitt and Bond (25). There is currently no marker for measuring the ileal flow of a solid meal.…”

Section: Discussionmentioning

confidence: 99%

Small-intestinal digestion of partially resistant cornstarch in healthy subjects

Champ¹,

Molis²,

Flourié³

et al. 1998

The American Journal of Clinical Nutrition

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The aims of this study were to measure the amount of starch from partially resistant starches (retrograded and complexed high-amylose cornstarches) escaping smallintestinal digestion in healthy humans by use of an intubation method and to compare these data with data obtained by indirect in vitro methods. Experiments were carried out in vivo in 6 healthy humans by using ileal intubation and stool analysis and in vitro by using 3 different methods for analyzing resistant starch. In intubated subjects, 51 ± 2% of the retrograded and 21 ± 2% of the complexed starch was delivered to the ileum and was fermented almost completely in the colon. In vitro estimates of the absorption of resistant starch were much lower. We conclude that technologically modified starches may substantially increase the amount of carbohydrate available for colonic fermentation in humans, but that in vitro measurements of resistant starch are inaccurate for predicting malabsorption in healthy humans.Am J Clin Nutr 1998;68:705-10.

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Starch malabsorption and breath gas excretion in healthy humans consuming low- and high-starch diets

Cited by 77 publications

References 30 publications

Starch intake and colorectal cancer risk: an international comparison

Starch intake and colorectal cancer risk: an international comparison

Digestion of raw banana starch in the small intestine of healthy humans: structural features of resistant starch

Small-intestinal digestion of partially resistant cornstarch in healthy subjects

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