Starch nanoparticles improve curcumin-induced production of anti-inflammatory cytokines in intestinal epithelial cells

Salah, Norhane; Dubuquoy, Laurent; Carpentier, Rodolphe; Betbeder, Didier

doi:10.1016/j.ijpx.2022.100114

Cited by 14 publications

(13 citation statements)

References 55 publications

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“…Additionally, in agreement with [ 35 ], our presented data revealed that CUR considerably boosted the serum levels of IL-10, a robust anti-inflammatory immunosuppressive and chondroprotective cytokine, indicating its potent anti-inflammatory capacity.…”

Section: Discussionsupporting

confidence: 91%

Ameliorative Effect of Curcumin Nanoparticles against Monosodium Iodoacetate-Induced Knee Osteoarthritis in Rats

Hamdalla

Ahmed

Galaly

et al. 2022

Mediators of Inflammation

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Aim. This study is aimed at evaluating the use of curcumin-loaded polylactic-co-glycolic acid nanoparticles (CUR-loaded PLGA NPs) as a treatment against monosodium iodoacetate- (MIA-) induced knee OA. Materials and Methods. Eighteen rats were assigned to three groups ( n = 6 ), namely, normal control group that received intra-articular injections (IAIs) of saline, an OA control group that received an IAIs of MIA (2 mg/50 μL), and a treatment group (MIA+CUR-loaded PLGA NPs) that received IAIs of CUR-loaded PLGA NPs (200 mg/kg b.wt). Results. The CUR NP treatment against knee OA alleviated radiographic alternations and histopathological changes and inhibited the upregulation in the serum levels of interleukin-1β, tumor necrosis factor-α, interleukin-6, and transforming growth factor-beta and the downregulation in interleukin-10. CUR NP-treated joints also decreased the mRNA expression of nuclear factor-kappa B and inducible nitric oxide synthase and the protein expression of matrix metalloproteinase-13 and caspase-3. Finally, CUR-loaded PLGA NP treatment mitigated the loss of type II collagen, which resulted in a significant reduction in malondialdehyde level and increased the glutathione content and superoxide dismutase activity compared with that of the OA group. Conclusion. This study demonstrated that the administration of CUR NPs could provide effective protection against MIA-induced OA and knee joint histological deteriorated changes due to its anti-inflammatory, antioxidant, and antiapoptotic properties.

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Section: Discussionsupporting

confidence: 91%

Ameliorative Effect of Curcumin Nanoparticles against Monosodium Iodoacetate-Induced Knee Osteoarthritis in Rats

Hamdalla

Ahmed

Galaly

et al. 2022

Mediators of Inflammation

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“…MD could be used to definitively map the drug loading and release mechanisms of stimuli-responsive formulations and as such design targeted dosage forms with highly explainable in vivo behaviours [161,252]. MD has also been used to understand the formation of polymer coated nanoparticles produced by flow nanoprecipitation, exemplifying how atom-level insight could be used to optimise colontargeted nanoformulations [257,258].…”

Section: In Silico Prediction For Colonic Drug Deliverymentioning

confidence: 99%

Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics

McCoubrey

Favaron

Awad

et al. 2023

Journal of Controlled Release

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“…For this reason, literature reports on drug carriers based on pure starch are rare, and only a few articles on this topic can be found, e.g., ST films as carriers for non-steroidal anti-inflammatory drugs [ 140 ]. An effective method to improve the properties of starch is an adequately selected cross-linking agent, e.g., maltodextrin [ 141 ], or double modification of the biopolymer in the presence of sulfobetaine and deoxycholic acid [ 142 ].…”

Section: Other Polysaccharidesmentioning

confidence: 99%

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

Kurczewska

2022

Polymers

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Polysaccharides constitute one of the most important families of biopolymers. Natural polysaccharide-based drug delivery systems are of constant interest to the scientific community due to their unique properties: biocompatibility, non-toxicity, biodegradability, and high availability. These promising biomaterials protect sensitive active agents and provide their controlled release in targeted sites. The application of natural polysaccharides as drug delivery systems is also intensively developed by Polish scientists. The present review focuses on case studies from the last few years authored or co-authored by research centers in Poland. A particular emphasis was placed on the diversity of the formulations in terms of the active substance carried, the drug delivery route, the composition of the material, and its preparation method.

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Starch nanoparticles improve curcumin-induced production of anti-inflammatory cytokines in intestinal epithelial cells

Cited by 14 publications

References 55 publications

Ameliorative Effect of Curcumin Nanoparticles against Monosodium Iodoacetate-Induced Knee Osteoarthritis in Rats

Ameliorative Effect of Curcumin Nanoparticles against Monosodium Iodoacetate-Induced Knee Osteoarthritis in Rats

Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

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