Despite substantial progress in social development during the post-colonial period, health inequalities in the South Asian countries were staggering, with reduced life expectancy, higher maternal and child mortality, and gender discrimination. Notably, even with the rapid economic growth during the neoliberal period, India fares below most of the South Asian countries in several health indicators. The Indian state of Kerala stands out with social sector gains; nevertheless, evidence indicates widening health inequalities, restricted public arenas, and undemocratic practices in health, particularly in the context of increasing market logic in the health and social arenas shaping health. The caste, class, gender, and ethnic ideologies and patriarchal power structure interwoven in the sociopolitical, cultural, moral, and health discourses similar to the South Asian context raise serious inequalities for health. At the launch of the United Nations' Sustainable Development Goals, the populations with lingering privations and forbidden freedoms for gaining better health in Kerala, similar to South Asia, were largely the dalits, ethnic and religious minorities, and women. This necessitates greater political interventions, recognizing the interacting effects of history, culture, social factors, politics, and policies on health. And public health research needs to underscore this approach.