State-Independent and Dependent Neural Responses to Psychosocial Stress in Current and Remitted Depression

Ming, Qingsen; Zhong, Xue; Zhang, Xiaocui; Pu, Weidan; Dong, Daifeng; Jiang, Yali; Gao, Yidian; Wang, Xiang; Detre, John A.; Yao, Shuqiao; Rao, Hengyi

doi:10.1176/appi.ajp.2017.16080974

Cited by 67 publications

(53 citation statements)

References 36 publications

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“…To assess the effects of stress, one-sample t -tests were performed in all subjects and in each group. Imaging results were corrected using a family-wise error rate for comparisons (significance at p < 0.05) [ 24 , 25 ].…”

Section: Methodsmentioning

confidence: 99%

“…The voxel locations of significant MA or pornographic cues activated in two groups ( P FWEcor < 0.05 and k = 30 voxels) were used to create masks for time course extraction, and 6-mm radius spherical regions of interest (ROI) were used to create masks. Using the masks, averaged time courses of multi voxels were calculated from each individual data with MarsBar 0.44 ( http://marsbar.sourceforge.net/ ) and log-roi-batch v2.0 ( http://www.aimfeld.ch/ ) [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

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Craving Responses to Methamphetamine and Sexual Visual Cues in Individuals With Methamphetamine Use Disorder After Long-Term Drug Rehabilitation

et al. 2018

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Studies utilizing functional magnetic resonance imaging (fMRI) cue-reactivity paradigms have demonstrated that short-term abstinent or current methamphetamine (MA) users have increased brain activity in the ventral striatum, caudate nucleus and medial frontal cortex, when exposed to MA-related visual cues. However, patterns of brain activity following cue-reactivity in subjects with long-term MA abstinence, especially long-term compulsory drug rehabilitation, have not been well studied. To enrich knowledge in this field, functional brain imaging was conducted during a cue-reactivity paradigm task in 28 individuals with MA use disorder following long-term compulsory drug rehabilitation, and 27 healthy control subjects. The results showed that, when compared with controls, individuals with MA use disorder displayed elevated activity in the bilateral medial prefrontal cortex (mPFC) and right lateral posterior cingulate cortex in response to MA-related images. Additionally, the anterior cingulate region of mPFC activation during the MA-related cue-reactivity paradigm was positively correlated with craving alterations and previous frequency of drug use. No significant differences in brain activity in response to pornographic images were found between the two groups. Compared to MA cues, individuals with MA use disorder had increased activation in the occipital lobe when exposed to pornographic cues. In conclusion, the present study indicates that, even after long-term drug rehabilitation, individuals with MA use disorder have unique brain activity when exposed to MA-related cues. Additionally, our results illustrate that the libido brain response might be restored, and that sexual demand might be more robust than drug demand, in individuals with MA use disorder following long-term drug rehabilitation.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Craving Responses to Methamphetamine and Sexual Visual Cues in Individuals With Methamphetamine Use Disorder After Long-Term Drug Rehabilitation

et al. 2018

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“…All of the participants were native Chinese speakers and screened for history of neurologic, cardiovascular, or psychiatric disease. Previous studies have found altered autonomic and pituitary adrenal responses to stress in humans with major depression (Carroll, Phillips, Hunt, & Der, 2007;Ming et al, 2017). To exclude effects of depression on stress responses, we used the Beck Depression Inventory-II (BDI-II; Beck, Steer, & Brown, 1996) during the screening process (Dedovic et al, 2005), and did not invite participants with scores >14 for participation, since scores above this cutoff indicate the presence of depressive symptomatology (Beck et al, 1996).…”

Section: Participantsmentioning

confidence: 99%

Acute psychological stress promotes general alertness and attentional control processes: An ERP study

Gao

2020

Psychophysiology

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The current study investigated the influence of acute psychological stress on selective attention processes. After an acute stressor or a control condition, 20 participants performed an arrow‐based version of the Eriksen flanker task, while ERPs (N1, N2, P3), reaction times, accuracy, subjective stress, and electrocardiogram signal were measured. Results showed elevated self‐report stress, negative affect, state anxiety, heart rate, and reduced high‐frequency heart rate variability in the stress block than in the control block, indicating that the flanker task was performed in a stressful situation. In the flanker task, faster response and larger flanker effect of accuracy were observed for the stress block relative to the control block, indicating increased arousal level and improved conflict detection under stress. Event‐related potentials locked to target stimuli in the flanker task revealed that (a) frontal N1 was amplified in the stress block than in the control block, indicating elevated vigilance level under stress; (b) frontal N2 was increased in the stress block than in the control block for both congruent and incongruent trials, indicating more intensive attention control under stress; and (c) Increased P3 in the stress block than in the control block may reflect more allocation of neural resources as a consequence of improved attentional control under stress. These findings suggest that acute psychological stress increases general alertness and promotes attentional control in selective attention processes.

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“…Previous studies reported altered stress reactivity in alcohol 44 and nicotine users 45 and elevated levels of anxiety and depression. 46 Cannabis users and controls in our sample were comparable regarding these potential confounders, suggesting specific effects of cannabis dependence on stress reactivity. Both groups exhibited high and comparable performance in the absence of stress indicating comparable baseline cognitive performance.…”

Section: Discussionmentioning

confidence: 53%

Impaired cognitive performance under psycho-social stress in cannabis-dependent males is mediated by attenuated precuneus activity

Zhao

Zimmermann

Zhou

et al. 2018

Preprint

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Background: Deficient regulation of stress plays an important role in the escalation of substance use, addiction and relapse. Accumulating evidence suggests dysregulations in cognitive and reward-related processes and the underlying neural circuitry in cannabis dependence. However, despite the important regulatory role of the endocannabinoid system in the stress response, associations between chronic cannabis use and altered stress processing on the neural level have not been systematically examined. Methods: Against this background, the present functional magnetic resonance imaging (fMRI)study examined psycho-social stress processing in cannabis-dependent males (n = 28) and matched controls (n = 23) using an established stress-induction paradigm (Montreal Imaging Stress Task) that combines computerized (adaptive) mental arithmetic challenges with social evaluative threat. Results: During psycho-social stress exposure, but not the no-stress condition, cannabis users demonstrated impaired performance relative to controls. In contrast, levels of experienced stress and cardiovascular stress responsivity did not differ from controls. Functional MRI data revealed that stress-induced performance deteriorations in cannabis users were accompanied by decreased precuneus activity and increased connectivity of this region with the dorsal medial prefrontal cortex. Limitations: Only male cannabis-dependent users were examined, the generalizability in female users remains to be determined. Conclusion: Together, the present findings provide first evidence for exaggerated stressinduced cognitive performance deteriorations in cannabis users. The neural data suggest that deficient stress-related dynamics of the precuneus may mediate the deterioration of performance on the behavioral level.

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State-Independent and Dependent Neural Responses to Psychosocial Stress in Current and Remitted Depression

Cited by 67 publications

References 36 publications

Craving Responses to Methamphetamine and Sexual Visual Cues in Individuals With Methamphetamine Use Disorder After Long-Term Drug Rehabilitation

Craving Responses to Methamphetamine and Sexual Visual Cues in Individuals With Methamphetamine Use Disorder After Long-Term Drug Rehabilitation

Acute psychological stress promotes general alertness and attentional control processes: An ERP study

Impaired cognitive performance under psycho-social stress in cannabis-dependent males is mediated by attenuated precuneus activity

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