State of Art on Solvent Casting Particulate Leaching Method for Orthopedic ScaffoldsFabrication

Prasad, Arbind; Sankar, Mamilla Ravi; Katiyar, Vimal

doi:10.1016/j.matpr.2017.01.101

Cited by 130 publications

(84 citation statements)

References 46 publications

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“…Solvent casting particle leaching SCPL is one of the most widely researched techniques for preparing polymer-based porous 3D scaffolds for bone tissue regeneration due to the simplicity and approachable of this method without any requirement of expensive equipment. 35,36 In principle, polymers are initially dissolved in an appropriate organic solvent to form a homogeneous polymer solution, and then the insoluble salt particles are admixed with the solution as poreforming agents. The mixture can be further cast into a suitable mold, and a salt-polymer composite could be shaped after vacuum drying to remove the residual organic solvent.…”

Section: Fabrication Of Three-dimensional Biomaterials Scaffolds For Bmentioning

confidence: 99%

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

2020

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Natural bone is a mineralized biological material, which serves a supportive and protective framework for the body, stores minerals for metabolism, and produces blood cells nourishing the body. Normally, bone has an innate capacity to heal from damage. However, massive bone defects due to traumatic injury, tumor resection, or congenital diseases pose a great challenge to reconstructive surgery. Scaffold-based tissue engineering (TE) is a promising strategy for bone regenerative medicine, because biomaterial scaffolds show advanced mechanical properties and a good degradation profile, as well as the feasibility of controlled release of growth and differentiation factors or immobilizing them on the material surface. Additionally, the defined structure of biomaterial scaffolds, as a kind of mechanical cue, can influence cell behaviors, modulate local microenvironment and control key features at the molecular and cellular levels. Recently, nano/micro-assisted regenerative medicine becomes a promising application of TE for the reconstruction of bone defects. For this reason, it is necessary for us to have in-depth knowledge of the development of novel nano/micro-based biomaterial scaffolds. Thus, we herein review the hierarchical structure of bone, and the potential application of nano/micro technologies to guide the design of novel biomaterial structures for bone repair and regeneration.

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Section: Fabrication Of Three-dimensional Biomaterials Scaffolds For Bmentioning

confidence: 99%

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

2020

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“…The porous nature of the composites favors water and nutrient infiltration into the scaffold, resulting in the improved growth and proliferation of cells. Bacterial cellulose and gelatin composite scaffolds have been fabricated using casting and particulate leaching approaches . The fabrication method permitted the preparation of porous scaffolds by dissolving the polymer in an organic solvent, followed by casting into a mold in the presence of porogen particles (e.g., salts).…”

Section: Gelatin–polysaccharides Composites In Cell Culture and Tissumentioning

confidence: 99%

“…Bacterial cellulose and gelatin composite scaffolds have been fabricated using casting and particulate leaching approaches. 108 The fabrication method permitted the preparation of porous scaffolds by dissolving the polymer in an organic solvent, followed by casting into a mold in the presence of porogen particles (e.g., salts). Subsequently, the solvent was evaporated, leaving the porogen-containing scaffold.…”

Section: Gelatin-cellulosementioning

confidence: 99%

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Afewerki

Sheikhi

Kannan

et al. 2018

Bioengineering & Transla Med

312

210

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Gelatin is a promising material as scaffold with therapeutic and regenerative characteristics due to its chemical similarities to the extracellular matrix (ECM) in the native tissues, biocompatibility, biodegradability, low antigenicity, cost‐effectiveness, abundance, and accessible functional groups that allow facile chemical modifications with other biomaterials or biomolecules. Despite the advantages of gelatin, poor mechanical properties, sensitivity to enzymatic degradation, high viscosity, and reduced solubility in concentrated aqueous media have limited its applications and encouraged the development of gelatin‐based composite hydrogels. The drawbacks of gelatin may be surmounted by synergistically combining it with a wide range of polysaccharides. The addition of polysaccharides to gelatin is advantageous in mimicking the ECM, which largely contains proteoglycans or glycoproteins. Moreover, gelatin–polysaccharide biomaterials benefit from mechanical resilience, high stability, low thermal expansion, improved hydrophilicity, biocompatibility, antimicrobial and anti‐inflammatory properties, and wound healing potential. Here, we discuss how combining gelatin and polysaccharides provides a promising approach for developing superior therapeutic biomaterials. We review gelatin–polysaccharides scaffolds and their applications in cell culture and tissue engineering, providing an outlook for the future of this family of biomaterials as advanced natural therapeutics.

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“…However, the electrospun scaffolds have two important limitations; (i) the pore size of these scaffolds are not large enough for cell penetration [12][13][14] , and (ii) the thickness of these scaffolds is less than one millimeter in many cases [15] . In order to overcome these limitations, the SCPL technique with high processability and fewer complications can be applied [16] . Fabrication of porous scaffold with acceptable thickness is possible by polymer casting method followed by particle leaching, a simple technique which is most widely used.…”

Section: Introductionmentioning

confidence: 99%

“…Two routes of the solvent-casting method are applicable to form porous scaffolds [16] . The first approach is dipping a mold into a polymeric solution and remove it after solvent evaporation which makes a layer of…”

Section: Introductionmentioning

confidence: 99%

Porogen Effect of Solvents on Pore Size Distribution of Solvent-Casted Polycaprolactone Thin Films

Safaei¹,

Khalili²,

Khorasani³

et al. 2018

JPSE

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In this study, the effect of porogenic solvents on pore size distribution of the polycaprolactone (PCL) thin films was investigated. Five thin PCL films were prepared using the solvent-casting method. Chloroform, Methylene Chloride (MC) and three different compositions of MC/ Dimethylformamide (DMF) (80/20, 50/50 and 20/80) were used as solvents. Scanning Electron Microscopy (SEM) investigations were employed to study morphology and consequently the pore size distribution of the prepared films. The PCL films made by chloroform and MC as a solvent were completely non-porous. Whereas the other films (made by a combination of MC and DMF) showed both uni-modal and bi-modal pore size distributions.

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State of Art on Solvent Casting Particulate Leaching Method for Orthopedic ScaffoldsFabrication

Cited by 130 publications

References 46 publications

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Porogen Effect of Solvents on Pore Size Distribution of Solvent-Casted Polycaprolactone Thin Films

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