State of the art: micro-nanorobotic manipulation in single cell analysis

Shen, Yajing; Fukuda, Toshio

doi:10.1186/s40638-014-0021-4

Cited by 35 publications

(20 citation statements)

References 92 publications

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“…In the last part of this section, we mention the micromanipulation techniques such as micropipette aspiration [22][23][24] or object handlings by microneedles [25], microknives [26], and microhands [27][28][29][30]. For more details of the nano/microrobots for the single cell analyses, see a comprehensive review [31]. Figure 1e shows the schematic image of the micropipette aspiration.…”

Section: Measurement Methods Of Cellular Mechanical Propertiesmentioning

confidence: 99%

On-chip cell manipulation and applications to deformability measurements

Ito

Kaneko

2020

Robomech J

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Active microfluidics for the applications to cellular deformability measurements is an emerging research field ranging from engineering to medicine. Here, we review conventional and microfluidic methods, and introduce an on-chip cell manipulation system with the design principle of fast and fine cell manipulation inside a microchannel. In the latter part of the review, we focus on the results of red blood cell (RBC) deformability measurements as one of the most frequently studied non-adherent cells by on-chip methods. The relationship between mechanical properties and biological structures/features, as well as medical/diagnostic applications, are also discussed.

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Section: Measurement Methods Of Cellular Mechanical Propertiesmentioning

confidence: 99%

On-chip cell manipulation and applications to deformability measurements

Ito

Kaneko

2020

Robomech J

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“…Another advantage of the proposed nanocoil is that magnetic nanostructures can be precisely manipulated by corkscrew motion in all three dimensions, using low magnitude magnetic fields. [24] Magnetic manipulation can be achieved by external systems that allow controlled locomotion in vivo (as previously demonstrated by our group [25] ), enabling non-invasive, targeted delivery of the nanocoils to the place of bacterial infection as well as post-treatment removal. Antibacterial activity of the nanocoils was successfully demonstrated against representative Gram-negative E. coli as well as Gram-positive S. aureus strains, which are known to cause life-threatening infections around the world.…”

Section: Introductionmentioning

confidence: 97%

Magnetically Driven Silver‐Coated Nanocoils for Efficient Bacterial Contact Killing

Hoop

Shen

Chen

et al. 2015

Adv Funct Materials

129

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The increasing threat of multidrug-resistant bacterial strains against conventional antibiotic therapies represents a significant worldwide health risk and intensifies the need for novel antibacterial treatments. In this work, an effective strategy to target and kill bacteria using silver-coated magnetic nanocoils is reported. The coil palladium (Pd) nanostructures are obtained by electrodeposition and selective dealloying, and subsequently coated with nickel (Ni) and silver (Ag) for magnetic manipulation and antibacterial properties, respectively. The efficiency of the nanocoils is tested in the treatment of Gram-negative Escherichia coli (E.coli) and Gram-positive methicillin-resistant Staphylococcus aureus (MRSA), both of which represent the leading multidrug-resistant bacterial pathogens. The nanocoils show highly effective bacterial killing activity at low concentrations and in relatively short durations of treatment time. Three different investigation techniques, LIVE/DEAD assay, Colony-Forming Unit (CFU) counting, and Scanning Electron Microscope (SEM), reveal that the antibacterial activity is a result of bacterial membrane damage caused by direct contact with the nanocoil. The low cytotoxicity towards fibroblast cells along with the capability of precise magnetic locomotion make the proposed nanocoil an ideal candidate to combat multidrug-resistant bacteria in the field of biomedical and environmental applications.

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“…A fully autonomous functional microrobot must sense the world for feedback. Finely controlled microrobots are applicable to multiple biological applications, such as single-cell manipulation [32,33] and the arrangement of cells in particular configurations in scaffolds for tissue engineering applications [34]. The ability to sense micro-forces accurately and in real-time is desired for the expansion of possible applications of mobile microrobots to areas like intelligent biomanipulation, mechanobiology, and even for advanced theranostics [35].…”

Section: Introductionmentioning

confidence: 99%

Towards Functional Mobile Microrobotic Systems

et al. 2019

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This paper presents our work over the last decade in developing functional microrobotic systems, which include wireless actuation of microrobots to traverse complex surfaces, addition of sensing capabilities, and independent actuation of swarms of microrobots. We will discuss our work on the design, fabrication, and testing of a number of different mobile microrobots that are able to achieve these goals. These microrobots include the microscale magnetorestrictive asymmetric bimorph microrobot ( μ MAB), our first attempt at magnetic actuation in the microscale; the microscale tumbling microrobot ( μ TUM), our microrobot capable of traversing complex surfaces in both wet and dry conditions; and the micro-force sensing magnetic microrobot ( μ FSMM), which is capable of real-time micro-force sensing feedback to the user as well as intuitive wireless actuation. Additionally, we will present our latest results on using local magnetic field actuation for independent control of multiple microrobots in the same workspace for microassembly tasks.

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State of the art: micro-nanorobotic manipulation in single cell analysis

Cited by 35 publications

References 92 publications

On-chip cell manipulation and applications to deformability measurements

On-chip cell manipulation and applications to deformability measurements

Magnetically Driven Silver‐Coated Nanocoils for Efficient Bacterial Contact Killing

Towards Functional Mobile Microrobotic Systems

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