State-of-the-art MRI techniques in neuroradiology: principles, pitfalls, and clinical applications

Viallon, Magalie; Cuvinciuc, Victor; Delattre, Bénédicte; Merlini, Laura; Barnaure-Nachbar, Isabelle; Toso-Patel, Seema; Becker, Minerva; Lövblad, Karl-Olof; Haller, Sven

doi:10.1007/s00234-015-1500-1

Cited by 75 publications

(56 citation statements)

References 196 publications

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“…Tournier et al (2011) defined a spatial resolution yielding acceptable artefact reduction: 2 × 2 × 2 mm 3 , and Viallon et al (2015) considered that a high spatial resolution should be fixed at 1 mm 3 (particularly for crossing-fiber regions; Oouchi et al, 2007). Moreover, it is recommended to use a 3 T MRI to reduce the noise (for all tissues), despite a possible increase in spatial distortions (Alexander et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Diffusion tensor imaging in Parkinson's disease: Review and meta-analysis

Atkinson-Clément

Pinto

Eusebio

et al. 2017

NeuroImage: Clinical

236

190

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BackgroundNeuroimaging studies help us better understand the pathophysiology and symptoms of Parkinson's disease (PD). In several of these studies, diffusion tensor imaging (DTI) was used to investigate structural changes in cerebral tissue. Although data have been provided as regards to specific brain areas, a whole brain meta-analysis is still missing.MethodsWe compiled 39 studies in this meta-analysis: 14 used fractional anisotropy (FA), 1 used mean diffusivity (MD), and 24 used both indicators. These studies comprised 1855 individuals, 1087 with PD and 768 healthy controls. Regions of interest were classified anatomically (subcortical structures; white matter; cortical areas; cerebellum). Our statistical analysis considered the disease effect size (DES) as the main variable; the heterogeneity index (I2) and Pearson's correlations between the DES and co-variables (demographic, clinical and MRI parameters) were also calculated.ResultsOur results showed that FA-DES and MD-DES were able to distinguish between patients and healthy controls. Significant differences, indicating degenerations, were observed within the substantia nigra, the corpus callosum, and the cingulate and temporal cortices. Moreover, some findings (particularly in the corticospinal tract) suggested opposite brain changes associated with PD. In addition, our results demonstrated that MD-DES was particularly sensitive to clinical and MRI parameters, such as the number of DTI directions and the echo time within white matter.ConclusionsDespite some limitations, DTI appears as a sensitive method to study PD pathophysiology and severity. The association of DTI with other MRI methods should also be considered and could benefit the study of brain degenerations in PD.

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Section: Discussionmentioning

confidence: 99%

Diffusion tensor imaging in Parkinson's disease: Review and meta-analysis

Atkinson-Clément

Pinto

Eusebio

et al. 2017

NeuroImage: Clinical

236

190

View full text Add to dashboard Cite

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“…DWI imaging of the whole brain was acquired using standard parameters (Viallon et al, 2015) whole brain coverage (34 slices, slice thickness 4 mm), parallel imaging (grappa factor = 2), 2 values (b = 0.1000). Main MR parameters were: TE = 95 ms, TR = 5500 ms, 4 averages, none interpolated pixel size 1.4375 × 1.4375, acquisition matrix 160 × 160, FOV 230 mm.…”

Section: Methodsmentioning

confidence: 99%

Extreme Mountain Ultra-Marathon Leads to Acute but Transient Increase in Cerebral Water Diffusivity and Plasma Biomarkers Levels Changes

et al. 2017

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Background: Pioneer studies demonstrate the impact of extreme sport load on the human brain, leading to threatening conditions for athlete's health such as cerebral edema. The investigation of brain water diffusivity, allowing the measurement of the intercellular water and the assessment of cerebral edema, can give a great contribution to the investigation of the effects of extreme sports on the brain. We therefore assessed the effect of supra-physiological effort (extreme distance and elevation changes) in mountain ultra-marathons (MUMs) athletes combining for the first time brain magnetic resonance imaging (MRI) and blood parameters.Methods:This longitudinal study included 19 volunteers (44.2 ± 9.5 years) finishing a MUM (330 km, elevation + 24000 m). Quantitative measurements of brain diffusion-weighted images (DWI) were performed at 3 time-points: Before the race, upon arrival and after 48 h. Multiple blood biomarkers were simultaneously investigated. Data analyses included brain apparent diffusion coefficient (ADC) and physiological data comparisons between three time-points.Results:The whole brain ADC significantly increased from baseline to arrival (p = 0.005) and then significantly decreased at recovery (p = 0.005) to lower values than at baseline (p = 0.005). While sodium, potassium, calcium, and chloride as well as hematocrit (HCT) changed over time, the serum osmolality remained constant. Significant correlations were found between whole brain ADC changes and osmolality (p = 0.01), cholesterol (p = 0.009), c-reactive protein (p = 0.04), sodium (p = 0.01), and chloride (p = 0.002) plasma level variations.Conclusions:These results suggest the relative increase of the inter-cellular volume upon arrival, and subsequently its reduction to lower values than at baseline, indicating that even after 48 h the brain has not fully recovered to its equilibrium state. Even though serum electrolytes may only indirectly indicate modifications at the brain level due to the blood brain barrier, the results concerning osmolality suggest that body water might directly influence the change in cerebral ADC. These findings establish therefore a direct link between general brain inter-cellular water content and physiological biomarkers modifications produced by extreme sport.

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“…A variety of contemporary non-invasive sequences are now available to aid structural, functional, and neurochemical characterization of the human brain, providing new opportunities to shed light on biological and pathological processes in vivo. 10 …”

Section: Introductionmentioning

confidence: 99%

Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder—a systematic review of the magnetic resonance neuroimaging literature

et al. 2017

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Since Emil Kraepelin's conceptualization of endogenous psychoses as dementia praecox and manic depression, the separation between primary psychotic disorders and primary affective disorders has been much debated. We conducted a systematic review of case-control studies contrasting magnetic resonance imaging studies in schizophrenia and bipolar disorder. A literature search in PubMed of studies published between January 2005 and December 2016 was conducted, and 50 structural, 29 functional, 7 magnetic resonance spectroscopy, and 8 combined imaging and genetic studies were deemed eligible for systematic review. Structural neuroimaging studies suggest white matter integrity deficits that are consistent across the illnesses, while gray matter reductions appear more widespread in schizophrenia compared to bipolar disorder. Spectroscopy studies in cortical gray matter report evidence of decreased neuronal integrity in both disorders. Functional neuroimaging studies typically report similar functional architecture of brain networks in healthy controls and patients across the psychosis spectrum, but find differential extent of alterations in task related activation and resting state connectivity between illnesses. The very limited imaging-genetic literature suggests a relationship between psychosis risk genes and brain structure, and possible gene by diagnosis interaction effects on functional imaging markers. While the existing literature suggests some shared and some distinct neural markers in schizophrenia and bipolar disorder, it will be imperative to conduct large, well designed, multi-modal neuroimaging studies in medication-naïve first episode patients that will be followed longitudinally over the course of their illness in an effort to advance our understanding of disease mechanisms.

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State-of-the-art MRI techniques in neuroradiology: principles, pitfalls, and clinical applications

Cited by 75 publications

References 196 publications

Diffusion tensor imaging in Parkinson's disease: Review and meta-analysis

Diffusion tensor imaging in Parkinson's disease: Review and meta-analysis

Extreme Mountain Ultra-Marathon Leads to Acute but Transient Increase in Cerebral Water Diffusivity and Plasma Biomarkers Levels Changes

Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder—a systematic review of the magnetic resonance neuroimaging literature

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