State-of-the-Art Multi-Detector CT Angiography in Acute Pulmonary Embolism: Technique, Interpretation and Future Perspectives

Hartmann, Ijc; Doorn, PJ Abrahams-van; Schaefer-Prokop, Cornelia

doi:10.5772/22763

Cited by 3 publications

(6 citation statements)

References 84 publications

(67 reference statements)

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“…For pregnant patients, low-dose techniques are commonly applied. In this study, the availability of iterative reconstruction allowed for low tube voltage-load combinations depending on the body size of the patient at the time of conception according to the scheme shown in Table 1, which conforms to a recently proposed scheme for exposure parameter selection for lowdose 256-slice CTPA (15).…”

Section: Ct Scanner and Ctpa Protocolmentioning

confidence: 79%

Perfusion Scintigraphy Versus 256-Slice CT Angiography in Pregnant Patients Suspected of Pulmonary Embolism: Comparison of Radiation Risks

et al. 2014

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One aim of the current study was to determine normalized dose data for maternal radiosensitive organs and embryo/fetus from 256-slice CT pulmonary angiography (CTPA) performed on pregnant patients suspected of having pulmonary embolism. A second aim was to provide reliable maternal and fetal doses and associated radiation cancer risk estimates from 256-slice CTPA and lung perfusion scintigraphy (LPS) for comparison. Methods: Mathematic anthropomorphic phantoms were generated to simulate the average woman at early pregnancy and at the third, sixth, and ninth months of gestation. In each phantom, 0-3 additional 1.5-cm-thick fat tissue layers were added to derive 4 phantoms representing pregnant women with different body sizes. Monte Carlo methods were used to simulate low-dose 256-slice CTPA exposures on each of the 16 generated phantoms. Normalized organ and embryo/fetal dose data were derived for exposures at 80, 100, and 120 kV. Maternal effective dose and embryo/fetal dose from 256-slice CTPA and associated lifetime attributable risks of radiation cancer were determined for different body sizes and gestational stages and compared with corresponding data from LPS. Results: For an average-sized pregnant patient at the first trimester, the 256-slice CTPA exposure resulted in a maternal effective dose of 1 mSv and an embryo/fetal dose of 0.05 mGy. However, maternal effective dose considerably increased with body size, whereas embryo/fetal dose increased with both body size and gestational stage. Compared with LPS, low-dose CTPA to an averagesized pregnant patient resulted in a 30% higher maternal effective dose but a 3.4-6 times lower embryo/fetal dose. Nevertheless, LPS was associated with less aggregated radiation risk for an average-sized pregnant patient, with the difference from CTPA being increased further for larger patients. Conclusion: Compared with CTPA performed with a modern wide-area CT scanner, LPS remains comparatively more dose-efficient.

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Section: Ct Scanner and Ctpa Protocolmentioning

confidence: 79%

Perfusion Scintigraphy Versus 256-Slice CT Angiography in Pregnant Patients Suspected of Pulmonary Embolism: Comparison of Radiation Risks

et al. 2014

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“…27 But, this study used a typical low-dose technique depending on the body size of the non-pregnant phantom (see Table I in Ref. [11]), which is in line with suggested scheme by Hartmann et al 27 to receive lower dose during CTPA. For an axial scan with pitch of 1 and scan length of 22 cm, the DLP values for three different scan setting of Table I were 163.68, 306.24, and 534.6, at tube voltages of 80, 100, and 120 kVp, respectively.…”

Section: B1 Ct Scanner Modelmentioning

confidence: 78%

“…But, this study used a typical low‐dose technique depending on the body size of the non‐pregnant phantom (see Table I in Ref. ), which is in line with suggested scheme by Hartmann et al . to receive lower dose during CTPA.…”

Section: Methodsmentioning

confidence: 86%

“…The scanning protocols for imaging pregnant patients with suspected PE was stated in ICRP publication 102 as tube voltage of 140 kVp, and tube current of 380 mA. 27 But, this study used a typical low-dose technique depending on the body size of the non-pregnant phantom (see Table I in Ref. [11]), which is in line with suggested scheme by Hartmann et al 27 to receive lower dose during CTPA.…”

Section: B1 Ct Scanner Modelmentioning

confidence: 84%

“…The typical exposure settings for adult non‐pregnant patients suspected of having PE are a tube voltage–load of 120 kV–200 mAs. The scanning protocols for imaging pregnant patients with suspected PE was stated in ICRP publication 102 as tube voltage of 140 kVp, and tube current of 380 mA . But, this study used a typical low‐dose technique depending on the body size of the non‐pregnant phantom (see Table I in Ref.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Pulmonary embolism in pregnant patients: Assessing organ dose to pregnant phantom and its fetus during lung imaging

et al. 2017

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An Enhanced Mask R-CNN Approach for Pulmonary Embolism Detection and Segmentation

Doğan,

Selçuk,

Alkan

2024

Diagnostics

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Pulmonary embolism (PE) refers to the occlusion of pulmonary arteries by blood clots, posing a mortality risk of approximately 30%. The detection of pulmonary embolism within segmental arteries presents greater challenges compared with larger arteries and is frequently overlooked. In this study, we developed a computational method to automatically identify pulmonary embolism within segmental arteries using computed tomography (CT) images. The system architecture incorporates an enhanced Mask R-CNN deep neural network trained on PE-containing images. This network accurately localizes pulmonary embolisms in CT images and effectively delineates their boundaries. This study involved creating a local data set and evaluating the model predictions against pulmonary embolisms manually identified by expert radiologists. The sensitivity, specificity, accuracy, Dice coefficient, and Jaccard index values were obtained as 96.2%, 93.4%, 96.%, 0.95, and 0.89, respectively. The enhanced Mask R-CNN model outperformed the traditional Mask R-CNN and U-Net models. This study underscores the influence of Mask R-CNN’s loss function on model performance, providing a basis for the potential improvement of Mask R-CNN models for object detection and segmentation tasks in CT images.

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State-of-the-Art Multi-Detector CT Angiography in Acute Pulmonary Embolism: Technique, Interpretation and Future Perspectives

Cited by 3 publications

References 84 publications

Perfusion Scintigraphy Versus 256-Slice CT Angiography in Pregnant Patients Suspected of Pulmonary Embolism: Comparison of Radiation Risks

Perfusion Scintigraphy Versus 256-Slice CT Angiography in Pregnant Patients Suspected of Pulmonary Embolism: Comparison of Radiation Risks

Pulmonary embolism in pregnant patients: Assessing organ dose to pregnant phantom and its fetus during lung imaging

An Enhanced Mask R-CNN Approach for Pulmonary Embolism Detection and Segmentation

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