State-of-the-art review - A review on snake venom-derived antithrombotics: Potential therapeutics for COVID-19-associated thrombosis?

Kalita, Bhargab; Saviola, Anthony J.; Samuel, Stephen P.; Mukherjee, Ashis K.

doi:10.1016/j.ijbiomac.2021.10.015

Cited by 12 publications

(5 citation statements)

References 217 publications

(278 reference statements)

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“…HDP-1 and HDP-2 are PLA2s that are isolated from V. nikolskii and could inhibit SARS-CoV-2 binding to ACE2 [ 67 ]. So, they can be effective in improving COVID-19 [ 68 ].…”

Section: Resultsmentioning

confidence: 99%

Harnessing the Natural Toxic Metabolites in COVID-19

Bahrami

Taheri

Arabestani

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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SARS-CoV-2 is a novel coronavirus and the cause of the recent pandemic; it is an enveloped β-coronavirus. SARS-CoV-2 appear in the Wuhan City of China for the first time and outspread worldwide quickly. Due to its person-to-person fast transmission, COVID-19 is becoming a global problem. SARS-CoV-2 enter into cells by using ACE2 receptors that are numerous in the lungs and finally can cause acute respiratory distress syndrome (ARDS). Dry cough, sore throat, fever, body pain, headache, GIT discomfort, diarrhoea, and fatigue are some of the COVID-19 symptoms. There is no definite and certain treatment for disease caused by SARS-CoV-2 till now. Some pharmacological effects of toxins, toxoids, and venoms have been proven, and their effects on some diseases have been evaluated. This study aimed to investigate the role of toxins, toxoids, and venom in the pathophysiology of COVID-19 disease.

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“…HDP-1 and HDP-2 are PLA2s that are isolated from V. nikolskii and could inhibit SARS-CoV-2 binding to ACE2 [ 67 ]. So, they can be effective in improving COVID-19 [ 68 ].…”

Section: Resultsmentioning

confidence: 99%

Harnessing the Natural Toxic Metabolites in COVID-19

Bahrami

Taheri

Arabestani

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Although a promising future is foreseen for venom-derived drugs, unfortunately, few studies focus on this [ 78 ]. For instance, there is a direct relationship of venom-derived toxins and the systems renin-angiotensin and kinin-kallikrein, with direct action on angiotensin-converting enzyme 2 (ACE2), and it is well known that SARS-COV-2 down-regulates ACE2, which significantly contributes to the pathophysiology of COVID-19 [ 71 , 79 ]; moreover, developing antithrombotic agents derived from snake venoms could be promising to prevent and treat cardiovascular disorders in COVID-19 patients since the clinical management of COVID-19-associated thrombosis is very complex, producing many challenges related to the use, dose, and choice of anticoagulants [ 80 ]; indeed, blood circulation, particularly thrombosis and haemostasis, is one of the major targets of several snake venom proteins [ 81 ].…”

Section: Venom-derived Toxins As Covid-19 Therapy: New Perspectivesmentioning

confidence: 99%

Harnessing the Power of Venomous Animal-Derived Toxins against COVID-19

Oliveira

Ferreira

Jacob

et al. 2023

Toxins

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Animal-derived venoms are complex mixtures of toxins triggering important biological effects during envenomings. Although venom-derived toxins are known for their potential of causing harm to victims, toxins can also act as pharmacological agents. During the COVID-19 pandemic, there was observed an increase in in-depth studies on antiviral agents, and since, to date, there has been no completely effective drug against the global disease. This review explores the crosstalk of animal toxins and COVID-19, aiming to map potential therapeutic agents derived from venoms (e.g., bees, snakes, scorpions, etc.) targeting COVID-19.

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“…Consequently, dietary zinc supplements may impact COVID-19-related symptoms like diarrhea, lower respiratory tract infection, and COVID-19. There are reports of various species, like Agaricus bisporus , that are valuable sources of supplements and contain a significant amount of absorbable minerals, like K, Fe, Zn, Cu, Ca, Na, Se, Mn, and Mg [ 90 ].…”

Section: Potential Of Natural Products Derived From Mushrooms For The...mentioning

confidence: 99%

“…Some commercial drugs are recommended for the treatment of COVID-19-associated thrombosis, categorized as blood thinner anticoagulants (argatroban—direct thrombin inhibitor, heparin—direct FXa inhibitor); antiplatelet drugs (abciximab—vitamin K antagonist); phosphodiesterase inhibitor (dipyridamole); and clot-bursting thrombolytic drugs (plasminogen activator). These drugs are handicapped by adverse reactions, drug–drug interactions, and a lack of detailed studies on COVID-19-related thrombosis [ 90 ]. In this context, mushroom extracts and natural compounds from mushrooms may be proposed as efficacious treatments of choice for COVID-19-associated thrombosis; nevertheless, intensive research and proper scientific validation are warranted.…”

Section: Potential Of Natural Products Derived From Mushrooms For The...mentioning

confidence: 99%

Therapeutic Potential of Bioactive Compounds from Edible Mushrooms to Attenuate SARS-CoV-2 Infection and Some Complications of Coronavirus Disease (COVID-19)

Baruah,

Patra,

Barge

et al. 2023

JoF

Self Cite

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The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a highly infectious positive RNA virus, has spread from its epicenter to other countries with increased mortality and morbidity. Its expansion has hampered humankind’s social, economic, and health realms to a large extent. Globally, investigations are underway to understand the complex pathophysiology of coronavirus disease (COVID-19) induced by SARS-CoV-2. Though numerous therapeutic strategies have been introduced to combat COVID-19, none are fully proven or comprehensive, as several key issues and challenges remain unresolved. At present, natural products have gained significant momentum in treating metabolic disorders. Mushrooms have often proved to be the precursor of various therapeutic molecules or drug prototypes. The plentiful bioactive macromolecules in edible mushrooms, like polysaccharides, proteins, and other secondary metabolites (such as flavonoids, polyphenols, etc.), have been used to treat multiple diseases, including viral infections, by traditional healers and the medical fraternity. Some edible mushrooms with a high proportion of therapeutic molecules are known as medicinal mushrooms. In this review, an attempt has been made to highlight the exploration of bioactive molecules in mushrooms to combat the various pathophysiological complications of COVID-19. This review presents an in-depth and critical analysis of the current therapies against COVID-19 versus the potential of natural anti-infective, antiviral, anti-inflammatory, and antithrombotic products derived from a wide range of easily sourced mushrooms and their bioactive molecules.

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State-of-the-art review - A review on snake venom-derived antithrombotics: Potential therapeutics for COVID-19-associated thrombosis?

Cited by 12 publications

References 217 publications

Harnessing the Natural Toxic Metabolites in COVID-19

Harnessing the Natural Toxic Metabolites in COVID-19

Harnessing the Power of Venomous Animal-Derived Toxins against COVID-19

Therapeutic Potential of Bioactive Compounds from Edible Mushrooms to Attenuate SARS-CoV-2 Infection and Some Complications of Coronavirus Disease (COVID-19)

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