State of the mononuclear phagocyte system after infusion of perfluorocarbon emulsions

Wistar albino rats were intravenously injected with 1 ml of an oxyphoretic emulsion of perfluorobutyl-furane and killed 3, 7 or 30 days later. Mitochondria isolated from the liver and kidneys of treated rats showed a small decrease in the transmembrane electrical potential and a substantial depression of the rates of both ATP synthesis and ADP-stimulated respiration. These alterations in mitochondrial oxidative phosphorylation appear to be induced by perfluorocarbon and/or tensioactive molecules interacting with hydrophobic cell structures.

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Alteration of mitochondrial bioenergetics due to intravenous injection of a perfluorocarbon emulsion

Branca

Chiarelli

Vincenti

et al. 1994

Experientia

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Perfluoran: Plasma substitute with oxygen transporting function

Голубев

1998

Bull Exp Biol Med

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Research carried out in Russia in the 1970s and 1980s, was aimed at creation of plasma substitute with gas-transporting function, and resulted in development of perfluoran. Perfluoran normalizes gas exchange and metabolism, transports oxygen and carbon dioxide, stabilizes cell membranes, corrects blood rheology and microcirculatory disorders, improves central hemodynamics, and exhibits adsorption and diuretic activities. It is effectively used in the treatment of hemorrhagic shock, intoxications, hemodynamic and cerebral circulation disorders, and hypoxia, in cardiosurgery, ophthalmology, and transplantology.

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State of the mononuclear phagocyte system after infusion of perfluorocarbon emulsions

Cited by 2 publications

References 2 publications

Alteration of mitochondrial bioenergetics due to intravenous injection of a perfluorocarbon emulsion

Alteration of mitochondrial bioenergetics due to intravenous injection of a perfluorocarbon emulsion

Perfluoran: Plasma substitute with oxygen transporting function

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