State-specific asymmetries in EEG slow wave activity induced by local application of TNFα

Yoshida, Hitoshi; Péterfi, Zoltán; García-García, Fabio; Kirkpatrick, Robert; Yasuda, Tadanobu; Krueger, James M.

doi:10.1016/j.brainres.2004.02.055

Cited by 85 publications

(73 citation statements)

References 36 publications

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“…These findings suggest that TNFα is involved in spontaneous EEG SWA and that EEG delta activity is generated in part within the cortex. Similar conclusions were reached previously after the demonstration that injection of TNFα onto the SSctx enhanced EEG SWA regionally whereas injection of the TNF soluble receptor reduced EEG SWA that had been enhanced by sleep loss (Yoshida et al, 2004). EEG SWA is posited to be indicative of sleep intensity (Borbely and Tobler 1989) because it is enhanced during the deep sleep following sleep deprivation (Pappenheimer et al, 1975).…”

Section: Discussionsupporting

confidence: 71%

“…TNFα expression in cortical neurons, as measured by immunohistochemistry, is enhanced after increased neural activity (Fix et al, 2006). Further, injection of TNFα onto the surface of the cortex enhances the amplitudes of electroencephalogram (EEG) delta (0.5-4 Hz) waves during NREMS (Yoshida et al, 2004). Such data implicate cortical TNFα in sleep regulation although there is a clear need for new tools to study endogenous TNFα.…”

Section: Introductionmentioning

confidence: 99%

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TNFα siRNA reduces brain TNF and EEG delta wave activity in rats

et al. 2007

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Tumor necrosis factor alpha (TNFα) is a pleiotropic cytokine with several CNS physiological and pathophysiological actions including sleep, memory, thermal and appetite regulation. Short interfering RNAs (siRNA) targeting TNFα were incubated with cortical cell cultures and microinjected into the primary somatosensory cortex (SSctx) of rats. The TNFα siRNA treatment specifically reduced TNFα mRNA by 45% in vitro without affecting interleukin-6 or gluR1-4 mRNA levels. In vivo the TNFα siRNAα reduced TNFα mRNA, interleukin-6 mRNA and gluR1 mRNA levels compared to treatment with a scrambled control siRNA. After in vivo microinjection, the density of TNFα-immunoreactive cells in layer V of the SSctx was also reduced. Electroencephalogram (EEG) delta wave power was decreased on days 2 and 3 on the side of the brain that received the TNFα siRNA microinjection relative to the side receiving the control siRNA. These findings support the hypothesis that TNFα siRNA attenuates TNFα mRNA and TNFα protein in the rat cortex and that those reductions reduce cortical EEG delta power. Results also are consistent with the notion that TNFα is involved in CNS physiology including sleep regulation.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

TNFα siRNA reduces brain TNF and EEG delta wave activity in rats

et al. 2007

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“…It seems that the results obtained are reliable, that is why the procedure was not verified. The works by Weiergräber et al (2005), and also by Yoshida et al (2004), who used 3 electrodes in the case of rats, seem to confirm the above-mentioned opinion.…”

Section: Electroencephalography Application In the Research On The Cesupporting

confidence: 53%

“…Such a procedure is justified by the fact that each species of animals has its own features, while the available literature does not specify sheep as research objects in an electroencephalographic technique. Standardization of the EEG record to a smaller extent is accepted by other researchers (Mumford et al 2001, Yoshida et al 2004, Weiergräber et al 2005, Ives et al 2006. They do not deny 10-20 system, however, they try to be more careful in its application among animal experimental methods.…”

Section: Determination Of a Normal Reaction Of The Cerebral Cortex Bimentioning

confidence: 99%

Recording of bioelectrical activity changes in sheep cerebral cortex

Cwynar

Zawadzki

2010

Arch. med. vet.

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RESUMENEl objetivo de este estudio es presentar el uso práctico de la electroencefalografía (EEG), demostrando el aspecto básico de EEG en ovejas, así como su utilidad en el análisis de las alteraciones provenientes del sistema nervioso central. Se examinaron 10 hembras híbridas de Oveja Merino Polaca, seleccionadas especialmente con fines experimentales. Debido a la falta de una fórmula unificada en el método de EEG en animales, se realizó un registro de potenciales provenientes de algunos puntos escogidos tras el experimento en cabezas de animales. Durante los experimentos realizados se demostró que la corteza cerebral de ovejas se caracteriza por una dinámica muy alta, hecho que fue demostrado al examinar las reacciones del sistema nervioso central a los factores tales como: el hambre, la estimulación auditiva o la inyección de xylazyna. La corteza cerebral de ovejas en el estado de reposo muestra una actividad bioeléctrica de una amplitud media de 30 μV y una frecuencia de 25 Hz, con lo cual se confirma la existencia del ritmo beta [β]. La aplicación de un estímulo acústico permite estimular el sistema nervioso central de oveja, lo que queda comprobado por una elevación de la amplitud media (por 23%) y de la frecuencia (por 21%) de la actividad bioeléctrica de la corteza cerebral, como también lo confirma el electroencefalograma conseguido. Los datos obtenidos demuestran que la zona que se caracteriza por tener el tiempo más corto de reacción es la zona del mesencéfalo, con un tiempo medio de reacción de 0,56 segundos (± 0,005 s). Se discute además la aplicabilidad de los experimentos, así como también la posibilidad de unificar el método de EEG.

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“…Process S dictates that greater brain use during wakefulness increases sleep need and is measured by greater u activity in the waking EEG 72 , 73 and higher amplitude EEG power in the d range (0.5-4.5 Hz) during NREM sleep. 58 On the network level, sleep onset is driven by activation of GABAergic and galanin neurons in the VLPO and MnPO. 65 Accumulation of extracellular adenosine during prior wakefulness has been posited as a primary input to these systems.…”

Section: Sleep Systems: Two-process Model Of Sleep Regulationmentioning

confidence: 99%

The Pathophysiology of Insomnia

Levenson

Kay

Buysse

2015

Chest

289

147

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Insomnia disorder is characterized by chronic dissatisfaction with sleep quantity or quality that is associated with diffi culty falling asleep, frequent nighttime awakenings with diffi culty returning to sleep, and/or awakening earlier in the morning than desired. Although progress has been made in our understanding of the nature, etiology, and pathophysiology of insomnia, there is still no universally accepted model. Greater understanding of the pathophysiology of insomnia may provide important information regarding how, and under what conditions, the disorder develops and is maintained as well as potential targets for prevention and treatment.The aims of this report are (1) to summarize current knowledge on the pathophysiology of insomnia and (2) to present a model of the pathophysiology of insomnia that considers evidence from various domains of research. Working within several models of insomnia, evidence for the pathophysiology of the disorder is presented across levels of analysis, from genetic to molecular and cellular mechanisms, neural circuitry, physiologic mechanisms, sleep behavior, and self-report. We discuss the role of hyperarousal as an overarching theme that guides our conceptualization of insomnia. Finally, we propose a model of the pathophysiology of insomnia that integrates the various types of evidence presented.

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State-specific asymmetries in EEG slow wave activity induced by local application of TNFα

Cited by 85 publications

References 36 publications

TNFα siRNA reduces brain TNF and EEG delta wave activity in rats

TNFα siRNA reduces brain TNF and EEG delta wave activity in rats

Recording of bioelectrical activity changes in sheep cerebral cortex

The Pathophysiology of Insomnia

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