-The paper studies the dynamics of the manufacturing sector in the Russian Federation, North Caucasus Federal District (NCFD) and Stavropol territory. It shows that it varies considerably by type of economic activity. It was found that the decline in output of mechanical engineering was the dominant factor that affected the level of business activity of adjacent industries. The estimation of the change of the index of business confidence organizations. In the structure of the manufacturing sector in economic activity of Stavropol region, the highest share of food production and chemical production was revealed. This chemical industry is developing based on innovation, and for the production of food, it is characterized by low investment activity, high depreciation of fixed assets, obsolete technology and lack of processing facilities in major vegetable and meat products. Their development is possible on the basis of an extensive system of interbranch relations by forming integrated structures, including a central unit ("core") -one of the leading manufacturing industries in the region. Solution of infrastructure and technology problems based on the integrative approach significantly strengthens the competitive position of local producers.