State-Supported Science and Imaginary Lock-in: The Case of Regenerative Medicine in Japan

Mikami, Koichi

doi:10.1080/09505431.2014.945410

Cited by 23 publications

(14 citation statements)

References 49 publications

(47 reference statements)

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“…We might ask, however, whether there is a different dynamic of inequity to be aware of in the evolving terrain of international regulatory differences, in terms of the politics of science and the flows of power within global scientific discourse. The importance of stem cell science and regenerative medicine to the national agenda in Japan [ 63 ] creates pressure toward policies intended to promote rapid advance in this field, in order to gain ground in the arena of global science and the biotechnology market. This drive must be understood in the context of an international scientific competition that has been heavily dominated by certain few and powerful countries, with adverse scientific, political and economic consequences for those countries that lag behind: the push toward expanded provision is a way for Japan itself to keep pace.…”

Section: Tapping the Multinational Research Marketmentioning

confidence: 99%

Current and Emerging Global Themes in the Bioethics of Regenerative Medicine: The Tangled Web of Stem Cell Translation

Chan

2017

Regen. Med.

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Probably the most serious problem facing the field of regenerative medicine today is the challenge of effective translation and development of viable stem cell-based therapies. Particular concerns have been raised over the growing market in unproven cell therapies. In this article, I explore recent developments in the stem cell therapy landscape and argue that while the sale of unproven therapies undoubtedly poses ethical concerns, it must be understood as part of a larger problem at the interface between biomedicine, healthcare, publics, policy and the market. Addressing this will require a broader perspective incorporating the shifting relationships between different stakeholder groups, the global politics of research and innovation, and the evolving role of publics and patients with respect to science.

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Section: Tapping the Multinational Research Marketmentioning

confidence: 99%

Current and Emerging Global Themes in the Bioethics of Regenerative Medicine: The Tangled Web of Stem Cell Translation

Chan

2017

Regen. Med.

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“…However, there is no consensus on whether ESCs and IPSCs can be treated interchangeably or on the therapeutic usefulness of IPSCs, which is yet to be confirmed. In many cases, IPSCs are used as tools for basic research or modeling diseases in a laboratory, rather than as sources for regenerative medicine (Anastacia et al, 2010; Mikami, 2015). The appearance of IPSCs has also raised questionings on the future of embryonic stem cell research Minger, 2008).…”

Section: Introductionmentioning

confidence: 99%

Shaping stem cell therapies in Argentina: regulation, risk management and innovation policies

2019

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This paper aims to analyze innovation pathways for stem cell technology in Argentina. Firstly, we present a theoretical perspective on the co-construction of regulation and technology development, positing four main tensions that underlie regulatory building and the shaping of national strategies for regenerative medicine. Regulation is understood as a negotiated process among interests, values, benefits, rewards, and different understandings of safety, efficacy, access and availability. The framework is useful to explore how actors and their visions of desired futures shape the creation of standards and, in turn, how they configure the way these emerging technologies are produced, accessed and used. Secondly, we discuss in detail the Argentine case. We focus on (a) the deployment of state actions on capacity and regulatory building, (b) the creation of new businesses in response to patient expectations, particularly umbilical cord stem cell banks and the supply of experimental treatments, and (c) state-led actions to build a specific regulatory framework (still in the making). Ambiguities and gaps in the current legislation as well as scarce enforcement capabilities configure a legal “grey area” for for-profit experimental treatments. Building a specific regulatory framework is understood to be a part of Science, Technology and Innovation (STI) state agencies’ struggle to govern technology development in terms of national envisaged innovation strategies. Lastly, we show how STI authorities and scientists managed to align a broad coalition of actors that encourage international harmonization strategies, following the pharmaceutical model of drug evaluation based on the multi-phase trial system.

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“…When it comes to science and ethics, a lack of ethical and political debate about stem cells, such as embryonic stem (ES) cells and iPS cells, led Japanese people, including scientists, journalists and politicians, to uncritically accept the discovery of STAP cells. As social scientists had already pointed out, without sufficient debate about uncertainty and safety of reprogramed cells or the donation and use of somatic cells Japanese policy jumped to the promotion of iPS cell research and medical applications (SleeboomFaulkner, 2008(SleeboomFaulkner, , 2011Mikami, 2014). The new book Good Science: The Ethical Choreography of Stem Cell Research by Charis Thompson provides various insights into how to rethink the relationship between stem cell science and ethics.…”

mentioning

confidence: 96%

A single step toward a ‘good science’ of stem cell research

Suzuki

2015

BioSocieties

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State-Supported Science and Imaginary Lock-in: The Case of Regenerative Medicine in Japan

Cited by 23 publications

References 49 publications

Current and Emerging Global Themes in the Bioethics of Regenerative Medicine: The Tangled Web of Stem Cell Translation

Current and Emerging Global Themes in the Bioethics of Regenerative Medicine: The Tangled Web of Stem Cell Translation

Shaping stem cell therapies in Argentina: regulation, risk management and innovation policies

A single step toward a ‘good science’ of stem cell research

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