Static electrification of powders during spray drying

Physical Characterization of Component Particles Included in Dry Powder Inhalers. II. Dynamic Characteristics

“…38 Triboelectrification [39][40][41][42] and triboelectric charging of pharmaceutical powders as a function of surface properties and relative humidity 34,[43][44][45][46] have been investigated. Furthermore, triboelectrification of lactose [47][48][49][50] and glucose 51 is known to occur during the process of spray-drying 52 lactose and mannitol, in miniaturized fluidized bed, 53,54 in powder coating applications 55,56 and during microscale granulation. 57 Additionally, electrostatic charging in lactose monohydrate during melt agglomeration and effects of surfactants on charging 58,59 have been demonstrated.…”

Investigation of Electrostatic Behavior of a Lactose Carrier for Dry Powder Inhalers

“…Static electrification of particles could be affected by several factors relating to the particle properties and contact surfaces such as particle size, shape, surface roughness, purity, fine particle content on coarse lactose carrier, contaminants, contact area, contact frequency, as well as the inherent electrical and mechanical properties of the contacting materials (4,10,15,21). Environmental factors with significant influences in static electrification are relative humidity and temperature.…”

“…A number of studies had examined the static electrification and charge relaxation behaviors of pharmaceutical powders associated with pharmaceutical processes such as powder mixing, coating, spray drying, melt agglomeration, powder transport and formulation of interactive mixtures for DPI in the attempt to understand the associated effects on these processes and improve quality of the eventual formulations (10)(11)(12)(13)(14)(15)(16)(17)(18). In order to mimic the powder processing conditions, a controlled triboelectrification step was often performed using turbula mixers, cyclone chargers or corona chargers to induce a considerable degree of static electrification on the powder particles.…”

The impact of electrostatic charge in pharmaceutical powders with specific focus on inhalation-powders

“…Electrostatic charge of Aerosil OX50 s during dispersing . (Murtomaa et al, 2004b). However, after collecting the powder from the spray-dryer the powder showed strong positive charge.…”

“…It can be applied to investigate the charging of particles in a cyclone by putting the cup around the collecting vessel and performing real time data logging (Eilbeck et al, 2000;Murtomaa et al, 2004b;Rowley, 2001;Rowley & Mackin, 2003). This technique provides good means to investigate the influence of contact material, surface contaminations and airflow rate on the charging process under realistic conditions.…”