2011
DOI: 10.1016/j.jaerosci.2011.02.010
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The impact of electrostatic charge in pharmaceutical powders with specific focus on inhalation-powders

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Cited by 102 publications
(46 citation statements)
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“…It is known that electrostatic charge is one of five mechanisms that govern the deposition of inhaled particles in the lungs (Karner and Urbanetz, 2011;Wong et al, 2015). Furthermore, the electrostatic charge of the plastic constituting the dry powder inhaler devices can have a strong impact on material loss during manufacturing of the product and upon actuation of the inhaler (Karner and Urbanetz, 2011).…”
Section: Spray Dried Sodium Hyaluronate Powders With Respirable Attrimentioning
confidence: 99%
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“…It is known that electrostatic charge is one of five mechanisms that govern the deposition of inhaled particles in the lungs (Karner and Urbanetz, 2011;Wong et al, 2015). Furthermore, the electrostatic charge of the plastic constituting the dry powder inhaler devices can have a strong impact on material loss during manufacturing of the product and upon actuation of the inhaler (Karner and Urbanetz, 2011).…”
Section: Spray Dried Sodium Hyaluronate Powders With Respirable Attrimentioning
confidence: 99%
“…Charged particles tend to adhere on the walls of the mixing vessel In the mixing process as well as to the inhaler material during loading and discharging and thus influence the released dose (Karner and Urbanetz, 2011;Wong et al, 2015).…”
Section: Spray Dried Sodium Hyaluronate Powders With Respirable Attrimentioning
confidence: 99%
“…In addition, particle charging can cause problems in the manufacture of formulations by affecting powder flow, reducing fill and dose uniformity [18,19]; for example particle charging may cause adhesion and deposition of particles to walls especially in case of fine particles such as in dry powder inhalers [20,21]. Triboelectrification has been used to study the impact of the counter ion on flurbiprofen salts as a consideration during the preformulation process [22], reduce the charging of flurbiprofen (a drug with a high propensity for charging) in binary mixtures of cellulose ethers [23], ordered mixing [24] and recently as a way of manipulating the charge of their final product of solid dispersions using single solvents and binary mixtures of solvents [25].…”
Section: Accepted M Manuscriptmentioning
confidence: 99%
“…To evaluate electrostatic forces and triboelectric charging, Faraday pails or wells are commonly used (Byron et al, 1997;Elajnaf et al, 2006;Karner and Urbanetz, 2011). Such a device basically consists of two conductive balls or wells of different sizes.…”
Section: Electrical Force Measurementsmentioning
confidence: 99%