Static magnetic fields increase tumor microvessel leakiness and improve antitumoral efficacy in combination with paclitaxel

Static magnetic field enhances the anticancer efficacy of capsaicin on HepG2 cells via capsaicin receptor TRPV1

“…Therefore, research looking for appropriate drugs and method which produce maximum effect and minimum unpleasant side effects is a matter of vital importance. Previous studies have shown that SMF has the ability to enhance the effect of some anti-cancer drugs [ 14 ]. However, most studies still remain focusd on conventional chemotherapy drugs.…”

“…Although the above results provided some understandings about the effect of SMF on cancer cells, most studies claimed that SMF as monotherapy is not sufficiently successful, but prefers the combinational effects with chemotherapy drugs [ 10 , 12 ]. For example, the efficacy of conventional chemotherapy drugs such as Taxol [ 13 , 14 ], Cisplatin [ 15 ], and Doxorubicin [ 12 ] were enhanced by moderate SMF with different intensities. These data indicate that SMF might be an assisted method for cancer chemotherapy, allowing minimum dosage of drugs to produce maximum curative effect.…”

“…Gellrich et al . found SMF increased tumor microvessel leakiness and improved antitumoral efficacy in combination with paclitaxel in vivo [ 14 ]. Nevertheless, the increased permeability can hardly explain the drug-specific synergism or antagonism behavior between SMF and different drugs [ 12 , 13 , 16 ], and so far little attention has been put on the interaction between SMF and drugs.…”

LF-MF suppresses the colon cancer via regulating the function of MDSCs

“…体内研究证实了低频磁场的抗肿瘤作 用, 包括促进肿瘤体积减小、存活时间延长 [11,12] . 关于 磁场抑制肿瘤生长的作用, Strieth等人 [14] . El-Bialy和Rageh [16] 也发现在荷Ehrlich腹水 瘤小鼠治疗过程中, 10 mT的极低频磁场联合顺铂能够 改变细胞膜通透性明显增强顺铂的治疗效果.…”

Decreased P‐glycoprotein is associated with the inhibitory effects of static magnetic fields and cisplatin on K562 cells

“…Evidence suggests that static magnetic fields (SMFs) not only influence the growth, proliferation, and structure of cancer cells [Chionna et al, 2003[Chionna et al, , 2005Dini and Abbro, 2005;Tenuzzo et al, 2006;Brix et al, 2008;Hsu and Chang, 2010;Yang et al, 2010] but also have the potential to enhance the cytotoxicity of chemical factors, especially chemotherapeutic drugs [Raylman et al, 1996;Gray et al, 2000;Sabo et al, 2002;Chen et al, 2010;Qi et al, 2011;Sun et al, 2012;Gellrich et al, 2014]. In the past two decades, accumulating evidence suggests that SMFs can enhance the killing effect of antineoplastic drugs on cancer cells, indicating that SMFs may act synergistically with pharmacological treatment [Gray et al, 2000;Sabo et al, 2002;Tofani et al, 2003].…”