Statin for Prevention of Atrial Fibrillation After Off-Pump Coronary Artery Bypass Grafting in Japanese Patients

Landiolol, an Ultra-Short-Acting β₁-Blocker, More Effectively Terminates Atrial Fibrillation Than Diltiazem After Open Heart Surgery

“…Regarding the effect of esmolol vs. calcium antagonists (verapamil or diltiazem) for postoperative AF: (1) esmolol was superior to calcium antagonists in the conversion rate 8, 16 and did not inhibit spontaneous conversion; 17 (2) there was no difference of heart rate control or the incidence of side-effects between esmolol and calcium antagonists; 7,8 and (3) intraoperative use of esmolol for heart rate control may worsen cardiac performance, as indicated by an increase of pulmonary arterial pressure or pulmonary vascular resistance. 18 In contrast, the present study showed that landiolol treatment led to a significantly higher rate of conversion than diltiazem treatment during the initial 8 h of therapy and that only one of 35 patients in the landiolol group had inadequate heart rate control during the 72-h observation period following the start of treatment.…”

Off-Pump Coronary Artery Bypass Grafting Revisited: Experience and Evidence from Japan

“…Kinoshita, et al 53) assessed the preventive effect of preoperative statin treatment on development of AF after elective isolated OPCAB. Among 584 patients, 364 patients received statin at least 5 days before surgery and 220 patients received no statin.…”

Potential Use of Statins in Reducing Atrial Fibrillation After Off-Pump Coronary Artery Bypass Grafting Surgery

“…13 Although this was not a randomized study, propensity score-matched analysis between the statin group and the no-statin group was performed to eliminate selection and treatment bias as much as possible. In their study, 195 patients in the statin group received any commercially available statin, including atorvastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin, and fluvastatin.…”