Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

Vieira-Silva, Sara; Falony, Gwen; Belda, Eugeni; Nielsen, Trine; Aron‐Wisnewsky, Judith; Chakaroun, Rima; Forslund, Kristoffer; Assmann, Karen E.; Valles‐Colomer, Mireia; Nguyen, Thi Thuy Duyen; Proost, Sebastian; Prifti, Edi; Tremaroli, Valentina; Pons, Nicolas; Andréelli, Fabrizio; Bastard, J.-P.; Coelho, Luís Pedro; Galleron, Nathalie; Hansen, Tue H.; Hulot, Jean‐Sébastien; Lewinter, Christian; Pedersen, Helle; Quinquis, Benoît; Rouault, Christine; Roume, Hugo; Salem, Joe‐Elie; Søndertoft, Nadja B; Touch, Sothea; Dumas, Marc; Ehrlich, S. Dusko; Galán, Pilar; Gøtze, Jens Peter; Holst, Jens J.; Køber, Lars; Letunić, Ivica; Nielsen, Jens; Oppert, Jean‐Michel; Stümvoll, Michael; Vestergaard, Henrik; Zucker, Jean-Daniel; Bork, Peer; Pedersen, Oluf; Bäckhed, Fredrik; Clément, Karine; Raes, Jeroen

doi:10.1038/s41586-020-2269-x

Cited by 348 publications

(328 citation statements)

References 44 publications

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“…Here we demonstrate that ImP levels were associated with a low abundance of microbial diversity and Bacteroides 2 enterotype, which previously have been linked to obesity 27…”

Section: Discussionsupporting

confidence: 56%

“…Here we demonstrate that ImP levels were associated with a low abundance of microbial diversity and Bacteroides 2 enterotype, which previously have been linked to obesity 27 and inflammatory bowel diseases 28 . These findings are consistent with the fact that subjects with type 2 diabetes have an altered microbiota including reduced diversity and reduced abundance of butyrate-producing bacteria including F. prauznitzii 1 – 6 .…”

Section: Discussionsupporting

confidence: 51%

“…2b ). This enterotype has been linked to low gene richness and low bacterial cell load as well as impaired metabolism 26 , 27 and pro-inflammatory conditions such as inflammatory bowel disease 28 , 29 . We next investigated if specific mOTUs were associated with ImP levels using a random forest approach.…”

Section: Resultsmentioning

confidence: 99%

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Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

et al. 2020

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Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.

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“…Here we demonstrate that ImP levels were associated with a low abundance of microbial diversity and Bacteroides 2 enterotype, which previously have been linked to obesity 27…”

Section: Discussionsupporting

confidence: 56%

Section: Discussionsupporting

confidence: 51%

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Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

et al. 2020

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“…Recently, it was shown in several cohorts that use of statins was associated with a lower prevalence of the unfavorable Bact2 enterotype. Bact2 is characterized by a high proportion of Bacteroides, a low proportion of Faecalibacterium and low microbial cell densities [153]. The administration of ezetimibe resulted in an increase in Lactobacillus species in mice [154].…”

Section: Discussion: Caveats In Research and Future Prospectsmentioning

confidence: 99%

How strong is the evidence that gut microbiota composition can be influenced by lifestyle interventions in a cardio-protective way?

et al. 2020

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“…evidence has showed that gut microbiota is involved in several physiological functions of the host, promotes growth and development, and maintains normal physiological activities, including digestion, metabolism, nutrient absorption, regulation of immune function, and vitamin synthesis ( Table 1; Adak and Khan, 2019). However, dysbioses of the gut microbiota is associated with unhealthy and disordered treatment outcomes (Marchesi et al, 2016;DeJong et al, 2020;Vieira-Silva et al, 2020).…”

Section: Human Gut Microbiotamentioning

confidence: 99%

Regulation of Gut Microbiota on Immune Reconstitution in Patients With Acquired Immunodeficiency Syndrome

et al. 2020

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Human immunodeficiency virus type 1 (HIV-1) infection of CD4 + T cells in the gut plays an insidious role in acquired immunodeficiency syndrome (AIDS) pathogenesis. Host immune function is closely related to gut microbiota. Changes in the gut microbiota cause a different immune response. Previous studies revealed that HIV-1 infection caused changes in gut microbiota, which induced immune deficiency. HIV-1 infection results in an abnormal composition and function of the gut microbiota, which may disrupt the intestinal epithelial barrier and microbial translocation, leading to long-term immune activation, including inflammation and metabolic disorders. At the same time, an abnormal gut microbiota also hinders the effect of antiviral therapy and affects the immune reconstruction of patients. However, studies on the impact of the gut microbiota on immune reconstitution in patients with HIV/AIDS are still limited. In this review, we focus on changes in the gut microbiota caused by HIV infection, as well as the impact and regulation of the gut microbiota on immune function and immune reconstitution, while we also discuss the potential impact of probiotics/prebiotics and fecal microbiota transplantation (FMT) on immune reconstitution.

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Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

Cited by 348 publications

References 44 publications

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

How strong is the evidence that gut microbiota composition can be influenced by lifestyle interventions in a cardio-protective way?

Regulation of Gut Microbiota on Immune Reconstitution in Patients With Acquired Immunodeficiency Syndrome

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