Statin Therapy Reduces Growth of Abdominal Aortic Aneurysms

Karrowni, Wassef; Dughman, Saadeddine; Hajj, Georges P.; Miller, Francis J.

doi:10.2310/jim.0b013e31823548e8

Cited by 55 publications

(34 citation statements)

References 64 publications

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“…For example, angiotensin II type 1 receptor blockers, telmisartan and irbesartan limited AAA enlargement in animal models (53) and pre-treatment or post-treatment with rosiglitazone reduced aortic aneurysms expansion and rupture concomitant with decreased expression of inflammatory mediators in mouse model (54). A retrospective study also found that patients receiving statins had a decreased AAA growth rate compared with those patients not receiving statins [0.9 mm/y (interquartile range, -1.0 to +1.0) vs. 3.2 mm/y (interquartile range, 2.0-4.9), p<0.0001], the difference in the rate of growth was maintained after adjusting for potential confounding factors (55).…”

Section: Discussionmentioning

confidence: 92%

Relation of diabetes to coronary artery ectasia: A meta-analysis study

Huang¹,

Li²,

Chen³

et al. 2014

Anadolu Kardiyol Derg

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Relation of diabetes to coronary artery ectasia: A meta-analysis study ABSTRACT Objective: Previous studies have shown a significant negative association between diabetes and abdominal aortic aneurysm. However, the relation of diabetes to coronary artery ectasia (CAE) has not well established. The aim of the current study was to conduct a systemic review for evaluating the relationship between diabetes and CAE. Methods: A systemic search of electronic databases (PUBMED, EMBASE, OVID, WEB OF SCIENCE, THE COCHRANCE LIBRARY) from 1970 to March 2013 was performed. Additionally, checking reference lists from identified articles, reviews, and the abstracts presented at related scientific meetings were also carried out. All case-control studies investigating appropriate prevalence data were included. Results: Among 328 articles, 10 case-control studies were finally identified. The prevalence of diabetes in studied patients with CAE was 8% to 33%, while in those without CAE was ranged from 13.5% to 35%. Pooled analysis showed a reduced rate of diabetes amongst patients with CAE compared to those without (OR 0.65, p<0.0001). Conclusion: Our findings suggested that diabetes might play a protective role for the development of CAE, indicating that further study is needed to evaluate the association diabetes and CAE including underlying mechanisms and future medical interventional strategies.

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Section: Discussionmentioning

confidence: 92%

Relation of diabetes to coronary artery ectasia: A meta-analysis study

Huang¹,

Li²,

Chen³

et al. 2014

Anadolu Kardiyol Derg

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“…166 With this observation, statins (hydroxymethylglutaryl-coenzyme A reductase inhibitors) and other lipid lowering drugs have been widely used for clinical studies, which have reported a decrease in AAA expansion rates. 57,81,145 Yet, the effect of statins has been ambivalent for most AAA cases, 48,82,149 and there is an undetermined possibility of cancer development 179 and adverse musculoskeletal and connective tissue disorders with statin use. 58 Doxycycline is one of the most studied drugs in AAA preclinical models 52 with the potential to inhibit MMP-2 and −9 174 and decrease AAA growth.…”

Section: Pgg As a Potential Therapeutic Option For Aaa Patientsmentioning

confidence: 99%

Pentagalloyl Glucose and Its Functional Role in Vascular Health: Biomechanics and Drug-Delivery Characteristics

et al. 2018

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Pentagalloyl glucose (PGG) is an elastin-stabilizing polyphenolic compound that has significant biomedical benefits, such as being a free radical sink, an anti-inflammatory agent, anti-diabetic agent, enzymatic resistant properties, etc. This review article focuses on the important benefits of PGG on vascular health, including its role in tissue mechanics, the different modes of pharmacological administration (e.g., oral, intravenous and endovascular route, intraperitoneal route, subcutaneous route, and nanoparticle based delivery and microbubble-based delivery), and its potential therapeutic role in vascular diseases such as abdominal aortic aneurysms (AAA). In particular, the use of PGG for AAA suppression and prevention has been demonstrated to be effective only in the calcium chloride rat AAA model. Therefore, in this critical review we address the challenges that lie ahead for the clinical translation of PGG as an AAA growth suppressor.

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“…10 Others have documented changes in the specific metalloproteinases implicated in AAA rupture in the arterial walls of patients treated with statins. 11 Recently, Karrowni et al 12 demonstrated decreases in the AAA expansion rates in patients treated with statins. They focused on 211 patients in a Veterans Affairs hospital who had undergone serial imaging surveillance.…”

Section: Commentmentioning

confidence: 99%

Decreases in Diameters of Treated Abdominal Aortic Aneurysms and Reduction in Rupture Rate

et al. 2013

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To determine whether the diameters of treated abdominal aortic aneurysms (AAAs) have changed during the last 10 years. Design, Setting, and Patients: A retrospective record review was completed on all patients undergoing any AAA repair from January 1, 2000, through December 31, 2009, at a single high-volume institution. All cases of repaired AAAs that had computed tomographic scans within 3 months of surgery were included. The mean and median maximal diameters of AAAs were noted. Correlation and regression analyses were used. Main Outcome Measures: The mean and median maximal diameters of AAAs. Results: Of 360 patients with treated AAAs, 339 met the inclusion criteria. The mean (SD) diameter of repaired AAAs decreased from 6.49 (1.46) cm (median, 6.40 cm) in 2000 to 5.83 (1.23) cm (median, 5.60 cm) in 2009. Correlation analysis confirmed a decrease in diameter across years (Pearson R=−0.141; P=.01). A fitted regression line also showed a decreasing trend (slope=−0.059 cm per year; P=.01). Conclusions: The diameters of repaired AAAs at our hospital have decreased progressively during the last decade. This observation is consistent with a reduction in the expansion rates of AAAs and may account for the progressive decreases in the aneurysm rupture rate in the United States.

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Statin Therapy Reduces Growth of Abdominal Aortic Aneurysms

Abstract: Background-The aim of this study was to evaluate the influence of statins on the growth of small abdominal aortic aneurysms (AAA).

Cited by 55 publications

References 64 publications

Relation of diabetes to coronary artery ectasia: A meta-analysis study

Relation of diabetes to coronary artery ectasia: A meta-analysis study

Pentagalloyl Glucose and Its Functional Role in Vascular Health: Biomechanics and Drug-Delivery Characteristics

Decreases in Diameters of Treated Abdominal Aortic Aneurysms and Reduction in Rupture Rate

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