Statistical analysis of observational study of the influence of radon and other risk factors on lung cancer incidence

Zhukovsky, Michael; Вараксин, А. Н.; Pakholkina, Olga

doi:10.1093/rpd/ncu069

Cited by 12 publications

(11 citation statements)

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“…Lung cancer is one of the most common human malignancies in the world and its mortality rate ranks first in cancer‐related causes of death . According to the histological features, lung cancer is divided into small cell lung cancer (SCLC) and non‐small cell lung cancer (NSCLC), and NSCLC accounts for approximately 80% or more . Although many novel treatment approaches have been developed for NSCLC, there are still no significant improvements in patient outcomes .…”

Section: Introductionmentioning

confidence: 99%

“…1 According to the histological features, lung cancer is divided into small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), and NSCLC accounts for approximately 80% or more. 2 Although many novel treatment approaches have been developed for NSCLC, there are still no significant improvements in patient outcomes. 3 Therefore, finding prognostic biomarkers is important for choosing suitable therapeutic strategies for the individual patient to acquire maximum treatment benefits.…”

Section: Introductionmentioning

confidence: 99%

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Long‐term prognostic significance of interleukin‐17‐producing T cells in patients with non‐small cell lung cancer

Wang

Chen

et al. 2019

Cancer Science

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The presence of interleukin (IL)‐17‐producing T cells has recently been reported in non‐small cell lung cancer (NSCLC) patients. However, the long‐term prognostic significance of these populations in NSCLC patients remains unknown. In the present study, we collected peripheral blood from 82 NSCLC patients and 22 normal healthy donors (NC). Percentages of IL‐17‐producing CD4+T (Th17), CD8+T (Tc17) and γδT cells (γδT17) were measured to determine their association with clinical outcomes and overall survival (OS) in NSCLC. All NSCLC patients were followed up until July 2018. Median follow‐up time was 13.5 months (range 1‐87 months). The 3‐ and 5‐year survival rate was 27% and 19.6%, respectively. We found that Th17 cells and γδT17 cells were significantly increased, whereas Tc17 cells were markedly decreased in patients with NSCLC compared with those in NC. In addition, Th17 cells were significantly positively associated with T helper type 1 cells (Th1), whereas γδT17 cells were significantly negatively associated with γδT + interferon (IFN)‐γ+ cells. High percentages of peripheral Tc17 cells were significantly associated with favorable 5‐year OS (P = .025), especially in patients with early TNM stage (P = .016). Furthermore, high percentages of peripheral Th17 cells were positively associated with favorable 5‐year OS in patients with late TNM stage (P = .002). However, no significant association was observed between γδT17 cells and OS, regardless of the TNM stage. In conclusion, our findings suggest that enhanced Th17 and reduced Tc17 cells in the peripheral blood could be a significant predictor of a favorable prognosis for NSCLC patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long‐term prognostic significance of interleukin‐17‐producing T cells in patients with non‐small cell lung cancer

Wang

Chen

et al. 2019

Cancer Science

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“…Pathological findings have indicated that lung cancer is a respiratory disease that may be associated with air contamination caused by industrial pollution ( 2 ). Non-small cell lung carcinoma (NSCLC) and small cell lung carcinoma are the two types of lung cancer, with incidence rates of ~85% and ~15%, respectively, according to a clinical statistical analysis of human cancers ( 3 ). NSCLCs include large-cell carcinoma, squamous cell carcinoma and adenocarcinoma, the incidences of which are increasing ( 4 – 6 ).…”

Section: Introductionmentioning

confidence: 99%

Metastasis-associated protein 2 promotes the metastasis of non-small cell lung carcinoma by regulating the ERK/AKT and VEGF signaling pathways

2018

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Non-small cell lung carcinoma (NSCLC) is the most common cause of cancer-associated mortality in the world and accounts for ~85% of human lung cancers. Metastasis-associated protein 2 (MTA2) is a component of the histone deacetylase complex and serves a role in tumor progression; however, the mechanism through which MTA2 is involved in the progression of NSCLC remains unclear. The aim of the present study was to investigate the expression and function of MTA2 and the MTA2-mediated signaling pathway in NSCLC cells. Expression of MTA2 and its target genes was analyzed in MTA2-overexpressing and anti-MTA2 antibody (AbMTA2)-treated NSCLC cells, as well as growth, migration, invasion and apoptotic-resistance. The inhibitory effects on tumor formation were analyzed using AbMTA2-treated NSCLC cells and in a mouse model. Histological assessment was conducted to analyze the expressions levels of extracellular signal-regulated kinase (ERK), RAC-α serine/threonine protein kinase (AKT) and vascular endothelial growth factor (VEGF) in experimental tumors. Results of the present study demonstrated that MTA2 was overexpressed in NSCLC cells. The growth, migration and invasion of NSCLC cells were markedly inhibited by AbMTA2. In addition, it was observed that the ERK/AKT and VEGF signaling pathways were both upregulated in MTA2-overexpressing NSCLC cells, and downregulated following silencing of MTA2 activation. ERK and AKT phosphorylation levels were downregulated in NSCLC cells and tumors following MTA2 silencing. The in vivo study demonstrated that tumor growth was markedly inhibited following siRNA-MTA2 treatment. In conclusion, the results of the present study suggested that MTA2 silencing may significantly inhibit the growth and aggressiveness of NSCLC cells. Results from the present study indicated that the mechanism underlying the MTA2-mediated invasive potential of NSCLC cells involved the ERK/AKT and VEGF signaling pathways, which may be a potential therapeutic target for the treatment of NSCLC.

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“…Lung cancer is the second most common cancer among men and women: second only to prostate cancer in men, and second only to breast cancer in women (Testa et al, 2018). Non-small cell lung cancer (NSCLC) and small cell lung cancer are two types of lung cancer, and NSCLC accounts for about 85% of all lung cancer cases (Zhukovsky et al, 2014). NSCLC, including large cell carcinoma, squamous cell carcinoma, and adenocarcinoma, is associated with high incidence and mortality (Barnett et al, 2016; Brody, 2014).…”

Section: Introductionmentioning

confidence: 99%

Circ_0005962 functions as an oncogene to aggravate non-small cell lung cancer progression via circ_0005962/miR-382-5p/PDK4 regulatory network

Zhenxiu¹,

Chen²,

Peng³

et al. 2020

Preprint

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Non-small cell lung cancer (NSCLC) is a leading threat to human lives with high incidence and mortality. Circular RNAs (circRNAs) were reported to play important roles in human cancers. The purpose of this study was to investigate the role of circ_0005962 and explore the underlying functional mechanisms. The expression of circ_0005962, miR-382-5p and pyruvate dehydrogenase kinase 4 (PDK4) was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Cell proliferation and cell apoptosis were assessed by cell counting kit-8 (CCK-8) assay and flow cytometry assay, respectively. The protein levels of Beclin 1, light chain3 (LC3-II/LC3-I), PDK4, Cleaved Caspase 3 (C-caspase 3) and proliferating cell nuclear antigen (PCNA) were examined using western blot analysis. Glycolysis was determined according to the levels of glucose consumption and lactate production. The interaction between miR-382-5p and circ_0005962 or PDK4 was predicted by the online tool CircInteractome or starbase and verified by dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay. Xenograft model was constructed to investigate the role of circ_0005962 in vivo. circ_0005962 expressed with a high level in NSCLC tissues and cells. Circ_0005962 knockdown inhibited proliferation, autophagy, and glycolysis but promoted apoptosis in NSCLC cells. MiR-382-5p was targeted by circ_0005962, and its inhibition reversed the role of circ_0005962 knockdown. Besides, PDK4, a target of miR-382-5p, was regulated by circ_0005962 through miR-382-5p, and its overexpression abolished the effects of miR-382-5p reintroduction. Circ_0005962 knockdown suppressed tumor growth in vivo. Circ_0005962 knockdown restrained cell proliferation, autophagy, and glycolysis but stimulated apoptosis through modulating the circ_0005962/miR-382-5p/PDK4 axis. Our study broadened the insights into understanding the mechanism of NSCLC progression.

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Statistical analysis of observational study of the influence of radon and other risk factors on lung cancer incidence

Cited by 12 publications

References 1 publication

Long‐term prognostic significance of interleukin‐17‐producing T cells in patients with non‐small cell lung cancer

Long‐term prognostic significance of interleukin‐17‐producing T cells in patients with non‐small cell lung cancer

Metastasis-associated protein 2 promotes the metastasis of non-small cell lung carcinoma by regulating the ERK/AKT and VEGF signaling pathways

Circ_0005962 functions as an oncogene to aggravate non-small cell lung cancer progression via circ_0005962/miR-382-5p/PDK4 regulatory network

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