The Inca Empire annexed the modern territory of Northwest Argentina ca. 1450 AD. Inca presence manifested regionally with different intensity, highlighting that the Empire carried out different strategies when interacting with conquered populations even within the same region. Regional fluctuations in power centralization may affect the quality of life of local groups, regarding access to food, labour, conflict, or inequality. In this paper, we analyse stable isotopes, dental, and osteological information to evaluate if the individuals that inhabited the archaeological site Esquina de Huajra (Quebrada de Humahuaca, Jujuy) experienced a deprived life quality under Inca administration. Isotopic results signal a balanced diet composed of both vegetal and animal resources, and skeletal indicators of health do not suggest a population undergoing stress.