Statistical analysis of reduced pair correlation functions of capillaries in the prostate gland

Mattfeldt, Torsten; Eckel, Stefanie; Fleischer, Frank; Schmidt, Volker

doi:10.1111/j.1365-2818.2006.01604.x

Cited by 41 publications

(81 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is a remarkable increase in the relative length of cancer microvessels in comparison with the prostatic capillaries of the CTR group, which is in agreement with the findings of other authors [17] and might be related to the increase of angiogenesis in both cancer and preinvasive lesions indicated by several others [2,9,12,18,24,25]. There were no significant differences in microvessel length density between young controls (CTR) and the carcinoma-free tissue from the cancer group (CA), i.e., controls of the same age as CA specimens, which excludes a possible age-dependent bias in the selection of young specimens as controls.…”

Section: Discussionsupporting

confidence: 82%

“…There were no significant differences in microvessel length density between young controls (CTR) and the carcinoma-free tissue from the cancer group (CA), i.e., controls of the same age as CA specimens, which excludes a possible age-dependent bias in the selection of young specimens as controls. These findings agree with those obtained by other authors [17] also using the peri-tumor prostate area as a control. Fig.…”

Section: Discussionsupporting

confidence: 82%

“…On the other hand, the number of profiles registered in a 2D plane of a linear feature that "lives" in a 3D space is, in fact, an estimate of the length of the linear structure, given by the expression: 2 · (number of profiles counted) / area of the section. This is actually the length density (L V ) of the linear structure [17]. The authors using MVD to estimate "number of vessels per unit of area" are underestimating the length density, because L V is equal to 2 · MVD.…”

Section: Discussionmentioning

confidence: 99%

“…Scarce rigorous stereological assessment has been performed regarding this matter [13], as most of the studies concerning quantification of microvessels employ microvessel density (MVD), or counting of the number of microvessel profiles [13][14][15][16]. Currently, MVD is not consistently defined and it seemed interesting to evaluate microvascularity by unbiased stereologic tools, such as length density (L V ) (defined as the length of microvessels per unit of volume of tissue) [17], to obtain more accurate and rigorous measurements.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Stereological Estimate of the Length of Microvessels and the Number, Proliferation and Apoptosis of Endothelial Cells in Prostate Cancer

Santamarı́a¹,

Ingelmo²,

Ruiz³

et al. 2009

TOPCANJ

View full text Add to dashboard Cite

Abnormal angiogenesis is a critical feature of many diseases, including cancers and their precursors. Although the association between prostate carcinogenesis and changes in microvascular architecture is well known, these changes are not well-documented from a quantitative point of view. The present work deals with stereological estimates of the number of quiescent and proliferative endothelial cells, and microvessel length in normal and prostate cancer tissues. Unbiased stereological measurements of numerical densities of proliferating cell nuclear antigen immunostained cells, nonproliferating endothelial cells, caspase 3 immunoreactive endothelial cells, and relative length (length density) of microvessels, were performed in control and cancer specimens. There were no changes in either proliferation or apoptosis in carcinoma endothelial cells. A decrease of endothelial cell density, together with an increase of microvessel length density, were detected in prostate cancer specimens. Therefore, the following conclusions can be drawn: a) The increase of angiogenetic activity in prostate carcinogenesis leads to an increment of the microvascular length; b) The amount of endothelial cells per vascular length decreases in prostate cancer; c) There is no decrease of endothelial apoptosis in cancer microvessels. d) The increase of the length density of microvessels in prostate cancer is not directly associated to an enhancement of the endothelial proliferation; and e) The blood supply of epithelium was similar in both cancerous and normal prostate.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Stereological Estimate of the Length of Microvessels and the Number, Proliferation and Apoptosis of Endothelial Cells in Prostate Cancer

Santamarı́a¹,

Ingelmo²,

Ruiz³

et al. 2009

TOPCANJ

View full text Add to dashboard Cite

show abstract

“…Fisher's g-test (Brockwell and Davis, 1991). Note that it is also possible to compute confidence intervals for the values κ(r) of the mark correlation function based on bootstrap estimates of κ(r), where a method suggested in Mattfeldt et al (2006) can be used. Here, to obtain bootstrap confidence intervals for κ(r), we create 1000 bootstrap samples S 1 , .…”

Section: Confidence Intervalsmentioning

confidence: 99%

Measuring the effects of geographical distance on stock market correlation

Eckel

Löffler

Maurer

et al. 2011

Journal of Empirical Finance

View full text Add to dashboard Cite

Recent studies suggest that the correlation of stock returns increases with decreasing geographical distance. However, there is some debate on the appropriate methodology for measuring the effects of distance on correlation. We modify a regression approach suggested in the literature and complement it with an approach from spatial statistics, the mark correlation function. For the stocks contained in the S&P 500 that we examine, both approaches lead to similar results: correlation increases with decreasing distance. Contrary to previous studies, however, we find that differences in distance do not matter much once the firms' headquarters are more than 40 miles apart, or separated through a federal border. Finally, we show through simulations that distance can significantly affect portfolio risk. Investors wishing to exploit local information should be aware that local portfolios are relatively risky.

show abstract

Characterization of the Spatial Arrangement of Secondary Osteons in the Diaphysis of Equine and Canine Long Bones

Shahar

Lukas

Papo

et al. 2011

The Anatomical Record

View full text Add to dashboard Cite

The blood supply of bone cells in compact bone is provided primarily by blood vessels located within Haversian canals forming the centre of osteons. Mid-diaphysial cross-sections of radii and third metacarpal bones from two horses and radii from two mature dogs were studied using reflective light microscopy to quantify the spatial ordering of canals and compared to a computational model. The distributions of canals were analyzed using: 1) the autocorrelation function (ACF), which describes the probability of finding two canals separated by a given distance and 2) the shortest distance distribution (SDD), which describes the probability that a site within bone is located at a given distance from the nearest canal. The order in the investigated horse radii, as characterized by the oscillations of the ACF, was found to be independent of the anatomical location although, in the metacarpal bone the order was higher in the lateral than in the cranial location. Among the dogs, marked differences were only found in the ACF. An analysis of the SDD demonstrates that ordering of canals minimizes the distance of osteocytes from a blood vessel. This suggests that the efficiency of the blood supply can be adapted through differences in the order of the Haversian canals. In our model, the ordering of canals is achieved via an exclusion zone around each canal, imposed upon newly formed osteons. Simulations demonstrate that differences in the observed order can be explained by either a larger size or a larger variability of this exclusion zone. Anat Rec, 294:1093Rec, 294: -1102Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

show abstract

Statistical analysis of reduced pair correlation functions of capillaries in the prostate gland

Cited by 41 publications

References 34 publications

Stereological Estimate of the Length of Microvessels and the Number, Proliferation and Apoptosis of Endothelial Cells in Prostate Cancer

Stereological Estimate of the Length of Microvessels and the Number, Proliferation and Apoptosis of Endothelial Cells in Prostate Cancer

Measuring the effects of geographical distance on stock market correlation

Characterization of the Spatial Arrangement of Secondary Osteons in the Diaphysis of Equine and Canine Long Bones

Contact Info

Product

Resources

About