It is essential for engineering manufacture and robust design to evaluate the impact of manufacturing variability on the aerodynamics of compressor blades efficiently and accurately. In the paper, a novel quadratic curve approximation method based on the scanning points of blade design profiles was introduced and combined with Karhunen–Loève expansion, a mathematical dimensionality reduction method for modeling manufacturing variability as truncated Normal process was proposed. Subsequently, Sparse Approximation of Moment-based Arbitrary Polynomial Chaos (SAMBA PC) and computational fluid dynamics (CFD) were applied to build a computational framework for stochastic aerodynamic analysis considering manufacturing variability. Finally, the framework was adopted to evaluate the aerodynamic variations of a high subsonic compressor cascade under the design incidence. The results illustrate that the SAMBA PC method is more efficient than the traditional methods such as Monte Carlo simulation (MCS) for stochastic aerodynamic analysis. Through uncertainty quantification, the impact of manufacturing variability on the global aerodynamic performance is primarily reflected in the fluctuation of aerodynamic losses, and the fluctuation of the total losses is mainly contributed by the fluctuation of the separation loss after the suction peak (a negative pressure spike near the leading edge (LE)) and the boundary-layer loss on the suction surface (SS). With sensitivity analysis, the most important geometric modes to aerodynamics can be revealed, which provides a useful reference for manufacturing inspection process and helps reduce computational cost in robust design.