Information and communication technology (ICT) has made remarkable impact on the society, especially on companies and organizations. The use of computers, databases, servers, and other technologies has made an evolution on the way of storing, processing, and transferring data. However, companies access and share their data on internet or intranet, thus there is a critical need to protect this data from destructive forces and from the unwanted actions of unauthorized users. This thesis groups a set of solutions proposed, from a company point of view, to reach the goal of "Managing data protection". The work presented in this thesis represents a set of security solutions, which focuses on the management of data protection taking into account both the organizational and technological side. The work achieved can be divided into set of goals that are obtained particularly from the needs of the research community. This thesis handles the issue of managing data protection in a systematic way, through proposing a Data protection management approach, aiming to protect the data from both the organizational and the technological side, which was inspired by the ISO 27001 requirements. An Information Security Management System (ISMS) is then presented implementing this approach, an ISMS consists of the policies, procedures, guidelines, and associated resources and activities, collectively managed by an organization, in the pursuit of protecting its information assets. An ISMS is a systematic approach for establishing, implementing, operating, monitoring, reviewing, maintaining and improving an organization's information security to achieve business objectives, The goal of ISMS is to minimize risk and ensure continuity by pro-actively limiting the impact of a security breach. To be well-prepared to the potential threats that could occur to an organization, it is important to adopt an ISMS that helps in managing the data protection process, and in saving time and effort, minimizes cost of any loss. After that, a comprehensive framework is designed for the security risk management of Cyber Physical Systems (CPSs), this framework represents the strategy used to manage the security risk management, and it falls inside the ISMS as a security strategy. Traditional IT risk assessment methods can do the job (security risk management for a CPS); however, and because of the characteristics of a CPS, it is more efficient to adopt a solution that is wider than a method that addresses the type, functionalities and complexity of a CPS. Therefore, there is a critical need to follow a solution that breaks the restriction to a traditional risk assessment method, and so a high-level framework is proposed, it encompasses wider set of procedures and gives a great attention to the cybersecurity of these systems, which consequently leads to the safety of the physical world. In addition, inside the ISMS, another part of the work takes place, suggesting the guidelines to select an applicable Security Incident and Event Management (SIEM) solution. It ...