Statistical Modelling and Optimization of Fermentation Medium for Lincomycin Production by Streptomyces lincolnensis Immobilized Cells

Abstract

Response surface methodology was used to optimize lincomycin production by Streptomyces lincolnensis NRRL ISP-

Contracts for biopharmaceutical manufacturing based on production cost and capabilities

“…Let Y ≡ (ȳ − ȳ). To capture the essence that additional effort can improve the yield in a simple manner, we shall focus on biopharmaceutical processes where the capabilities of parties have a linear impact on yield and quality (Abdelwahed, Gomaa, and Hassan 2017;Kalbfuss et al 2008;Lila et al 2004). Using these definitions, the fraction of yield requirement met y(e c , e p ) is given by Equation (1).…”

“…We let q ∈ [0, 1] and q ∈ [0, 1] be the maximum and minimum fractions of low-quality output, respectively, and Q ≡ (q − q). For ease of exposition and analytical tractability, we focus on the cases when q(e c , e p ) is a decreasing function in e c and e p , and the capabilities of parties have a linear impact on quality (Abdelwahed, Gomaa, and Hassan 2017;Kalbfuss et al 2008;Lila et al 2004). Using these definitions, the function of q(e c , e p ) is given by Equation (2).…”