Statistical optimization of dithranol-loaded solid lipid nanoparticles using factorial design

Gambhire, Makarand S; Bhalekar, Mangesh R.; Gambhire, Vaishali M.

doi:10.1590/s1984-82502011000300008

Cited by 26 publications

(16 citation statements)

References 15 publications

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“…Gambhire and others (2011) observed that higher sonication times produced smaller nanoparticles made of dithranol, Compritol 888 ATO, and Span 60 (3% (w/v)). [25] Gupta and others (2016) reported that smaller particles were obtained by increasing the time and the amplitude of the sonication step when they encapsulated an anticancer agent in glyceryl distearate nanoparticles. [26] On the contrary, other authors have found an increment of the particle size due to higher ultrasonication times or amplitude.…”

Section: Effect Of Time and Amplitude Of The Sonication Processmentioning

confidence: 99%

Size and Vitamin E Release of Nanostructured Lipid Carriers with Different Liquid Lipids, Surfactants and Preparation Methods

Souza

Sáez

Campos

et al. 2019

Macromolecular Symposia

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Solid lipid nanoparticles have excellent properties as delivery systems for dermal cosmetic and pharmaceutical formulations because they have good compatibility with the skin, protect the encapsulated substance from the medium, and control its release at the site of action. This work describes the preparation and characterization of nanostructured lipid carriers (NLC) containing vitamin E (NLC‐VE). The emulsion‐solidification technique was used to prepare the particles. Three non‐ionic surfactants (Tween 80, Cremophor RH40 and Pluronic F‐127) were used in two concentrations (5 and 10% (w/w)) and three liquid lipids (avocado oil, coconut oil and medium chain triglycerides (MCT)) were mixed with the solid lipid (stearic acid) to form the oil phase. Some processing variables (emulsification procedure, and time and energy during sonication) were modified to find the most suitable NLC in terms of particle size and release profile. Higher surfactant concentration produced more homogeneous nanoparticles with smaller diameter. The liquid lipid and its proportion in the oil phase also modified the characteristics of NLC‐VE. Time and sonication energy did not strongly affect the particle size (24–28 nm), with the exception of the highest time and amplitude, which produced particles with 14 nm. NLC‐VE prepared with stearic acid as solid lipid, 10% (w/w) Tween 80 as surfactant, and MCT as liquid lipid in a 1:3 mass proportion of solid lipid‐to‐liquid lipid, had a unimodal size distribution and the best vitamin E release (50% in 24 h). Results indicate that this system can be used to improve the delivery of vitamin E.

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Section: Effect Of Time and Amplitude Of The Sonication Processmentioning

confidence: 99%

Size and Vitamin E Release of Nanostructured Lipid Carriers with Different Liquid Lipids, Surfactants and Preparation Methods

Souza

Sáez

Campos

et al. 2019

Macromolecular Symposia

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“…This result could be attributed to the increased viscosity of the antisolvent (water) by increasing polymer molecular weight and inhibition of nanoparticle growth during solvent evaporation leading to the formation of small nanoparticles. The increased amount and molecular weight of the used polymer could also reduce the chance of nanoparticle aggregation by the formation of hydrophilic coat around the formed nanoparticles [22,23] .…”

Section: Determination Of Particle Size Count Rate and Polydispersimentioning

confidence: 99%

Hydrogel Containing PEG-Coated Fluconazole Nanoparticles with Enhanced Solubility and Antifungal Activity

et al. 2018

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Purpose The aim of this study was to prepare fluconazole (FLC) nanoparticles coated with polyethylene glycol (PEG) in the form of FLC-PEG-NPs and optimize the size and entrapment efficiency. Methods Nine formulae were prepared by solvent antisolvent precipitation technique according to full 3 2 factorial designs. The effects of PEG molecular weight (X 1 ) and the drug polymer ratio (X 2 ) on the particle size (Y 1 ) and entrapment efficiency (Y 2 ) were explored. The prepared FLC-PEG-NPs were investigated for particle size, count rate, PDI, zeta potential, and morphology. Carbopol hydrogel was prepared, loaded with optimized FLC-PEG-NPs, and characterized for pH, FLC content, viscosity, homogeneity and spreadability, in vitro release, skin permeation, and antifungal activity. Results The formulated nanoparticles were uniform in size and spherical in shape with slightly rough surface and free from aggregations. The effect of PEG molecular was antagonistic on the particle size and was agonistic on EE %. The release of drug from hydrogel containing pure FLC was always lower than that from hydrogel containing FLC-PEG-NPs. The kinetic analysis of drug release obeys first-order release model and super case II transport mechanism. The cumulative amount of drug permeated applying hydrogel containing optimized FLC-PEG-NPs was significantly higher than the amount permeated using pure fluconazole containing hydrogel. The antifungal activity of hydrogel containing FLC in the form of optimized PEG-coated nanoparticles was better than hydrogel containing pure drug as indicated by relatively high inhibition zone using agar well-diffusion method. Conclusion Small spherical FLC nanoparticles with enhanced in vitro drug release as well as improved antifungal activity could be achieved by using PEG-coated fluconazole nanoparticles.

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“…e extract was entrapped into the lipid matrix due to the structure of NLCs consisting of medium chain triglycerides with free spaces capable of holding a certain amount of the extract. Entrapment efficacy depends on the amount of the lipid, the solubility of the compounds in lipid, and the concentration of the surfactant [23,36].…”

Section: Entrapment Efficacy and Extract Loading Of Cp-loadedmentioning

confidence: 99%

Improvement of Stability and Transdermal Delivery of Bioactive Compounds in Green Robusta Coffee Beans Extract Loaded Nanostructured Lipid Carriers

Nitthikan

Leelapornpisid

Natakankitkul

et al. 2018

Journal of Nanotechnology

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e aim of this study was to develop green robusta coffee beans extract loaded nanostructured lipid carriers (NLCs) for enhancing dermal application and its efficiency. e green robusta coffee beans extract cultivated in Chumphon (CP) exhibited the highest antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay with IC 50 of 34.1 ± 0.9 µg/ml, lipid peroxidation inhibition with percentage inhibition of 38.8 ± 1.7, and ferric reducing antioxidant power (FRAP) assay with a FRAP value of 234.5 ± 12.3 mM FeSO 4 /g. e extract contained caffeine, chlorogenic acid, and caffeic acid as major compounds. e anti-inflammatory test indicated that CP could decrease the secretion of IL-6 in macrophage cells and caused no irritation to blood vessels on the irritation test by hen's egg test chorioallantoic membrane (HET-CAM) assay. e particle size of CP-loaded NLCs was 158.1 ± 0.2 nm with a narrow polydispersity index and showed no noticeable difference after the stability test. Entrapment efficacy of CP-loaded NLCs was found to be over 60%. Caffeine and chlorogenic acid in CP-loaded NLCs were released sustainably and penetrated deeper into the skin than the extract in a conventional emulsion. In conclusion, the CP-loaded NLCs can be further used in cosmetics for dermal applications due to good efficacy and safety.

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Statistical optimization of dithranol-loaded solid lipid nanoparticles using factorial design

Cited by 26 publications

References 15 publications

Size and Vitamin E Release of Nanostructured Lipid Carriers with Different Liquid Lipids, Surfactants and Preparation Methods

Size and Vitamin E Release of Nanostructured Lipid Carriers with Different Liquid Lipids, Surfactants and Preparation Methods

Hydrogel Containing PEG-Coated Fluconazole Nanoparticles with Enhanced Solubility and Antifungal Activity

Improvement of Stability and Transdermal Delivery of Bioactive Compounds in Green Robusta Coffee Beans Extract Loaded Nanostructured Lipid Carriers

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