Statistical Tests for Comparing Pareto Charts

Grzegorzewski, Przemysław

doi:10.5899/2012/cna-00110

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…Pareto charts were used for quantitatively recognizing the influence of each studied factors on the selected CQAs for screening. The objective of the pareto chart is to screen the most influential factor(s) among a typical large set of factor variables [32]. Based on Pareto chart (fig.…”

Section: Screening Of Influencing Factorsmentioning

confidence: 99%

Development and Statistical Optimization of Gastroretantive Floating Microspheres of Pregabalin Prepared by W/O/O Multiple Emulsion Method

Kharb¹,

Tanwar²

2021

Int J App Pharm

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Objective: The aim of this study is to develop a gastroretentive microsphere of pregabalin using design of experiment (DoE) to decrease dosing frequency and increasing bioavailability. Methods: Pregabalin microsphere was prepared by W/O/O multiple emulsion method using a mixture of ethyl cellulose (EC) and polyvinyl pyrrolidone (PVP) as rate-controlling polymer. Mixed solvent system comprising of dichloromethane (DCM) and acetonitrile (ACN) and light liquid paraffin was chosen as primary and secondary oil phase respectively. Taguchi design was employed for factor screening and Box Behnken design was used for the optimisation of critical process parameters. Results: Taguchi design revealed that polymer: drug, DCM: ACN and PVP: EC is the critical factor for the preparation of microspheres. The optimized formulation was prepared using polymer: drug (4.95:1), DCM: ACN (53.76: 46.24) and PVP: EC (2:5) which showed mean particle size of 203.34±4.82 µm, practical yield of 87.52±2.91 %, encapsulation efficiency of 96.43±3.14 %, floating ability up to 90.42±1.64 % and T60% of 332.81±5.84. Drug release from microsphere followed Higuchi Kinetic model. Conclusion: In a nutshell, microspheres with excellent flowability and great encapsulation efficiency were successfully developed. These can be useful in improving patient compliance by reducing frequent dosing.

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Section: Screening Of Influencing Factorsmentioning

confidence: 99%

Development and Statistical Optimization of Gastroretantive Floating Microspheres of Pregabalin Prepared by W/O/O Multiple Emulsion Method

Kharb¹,

Tanwar²

2021

Int J App Pharm

View full text Add to dashboard Cite

show abstract

“…12 One possible way of analyzing the partitioned data would be to create a Pareto chart for each factory and compare them against each other. This process has been investigated previously, 13,14 however 30 factories can be grouped into 435 pairs, so a pairwise comparison is not the ideal solution when there are many samples.…”

Section: Motivationmentioning

confidence: 99%