Flip-flops are the most used sequential elements in synchronous circuits, but designs based on latches can operate at higher frequencies and occupy less area. Techniques to increase the maximum operating frequency of flip-flop based designs, such as time-borrowing, rely on tight hold constraints that are difficult to satisfy using traditional back-end optimization techniques. We propose Mix & Latch, a methodology to increase the operating frequency of synchronous digital circuits using a single clock tree and a mixed distribution of positive-and negative-edge-triggered flops, and positive-and negative-levelsensitive latches. An efficient mathematical model is proposed to optimize the type and location of the sequential elements of the circuit. We ensure that the initial registers are not moved from their initial location, although they may change type, thus allowing the use of equivalence checking and static timing analysis to verify formally the correctness of the transformation. The technique is validated using a 28 nm CMOS FDSOI technology, obtaining 1.33 X post-layout average operating frequency improvement on a broad set of benchmarks over a standard commercial design flow. Additionally, the circuit area was also reduced by more than 1.19 X on average for the same benchmarks, although the overall area reduction is not a goal of the optimization algorithm. To the best of our knowledge, this is the first work that proposes combining mixed-polarity flip-flops and latches to improve the circuit performance.